Androgen regulation of gene expression.

Kristin R. Lamont, Donald J. Tindall

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Original languageEnglish (US)
Pages (from-to)137-162
Number of pages26
JournalAdvances in cancer research
Volume107
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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