Androgen Regulation of Gene Expression

Kristin R. Lamont, Donald J. Tindall

Research output: Chapter in Book/Report/Conference proceedingChapter

76 Scopus citations

Abstract

The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc
Pages137-162
Number of pages26
DOIs
StatePublished - Jan 2010

Publication series

NameAdvances in Cancer Research
Volume107
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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