Androgen receptor in human health: A potential therapeutic target

Hifzur Rahman Siddique, Sanjeev Nanda, Aijaz Parray, Mohammad Saleem

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Androgen is a key for the activation of Androgen Receptor (AR) in most of the disease conditions, however androgen-independent activation of AR is also found in aggressive type human malignancies. An intense search for the inhibitors of AR is underway to cure AR-dependent diseases. In addition to targeting various components of AR signaling pathway, compounds which directly target AR are under preclinical and clinical investigation. Various In vitro and preclinical animal studies suggest that different natural compounds have potential to act against AR. Some natural compounds have been found to be pharmacologically effective against AR irrespective of varying routs of administration viz; oral, intra-peritoneal and intravenous. This mini-review summarizes the studies conducted with different natural agents in determining their pharmacological utility against AR signaling.

Original languageEnglish (US)
Pages (from-to)1907-1916
Number of pages10
JournalCurrent drug targets
Volume13
Issue number14
DOIs
StatePublished - 2012

Keywords

  • Androgen receptor
  • Cancer
  • Natural compounds
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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