Androgen Action in Prostate Cancer

Sujit Basu, Donald J. Tindall

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalHormones and Cancer
Volume1
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Androgens
Prostatic Neoplasms
Prostate
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Transcription Factors
Maintenance
Health
Therapeutics
Growth
Neoplasms

Keywords

  • Androgen
  • Androgen ablation therapy
  • Prostate

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Androgen Action in Prostate Cancer. / Basu, Sujit; Tindall, Donald J.

In: Hormones and Cancer, Vol. 1, No. 5, 10.2010, p. 223-228.

Research output: Contribution to journalArticle

Basu, Sujit ; Tindall, Donald J. / Androgen Action in Prostate Cancer. In: Hormones and Cancer. 2010 ; Vol. 1, No. 5. pp. 223-228.
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