Androgen Action in Prostate Cancer

Sujit Basu, Donald J. Tindall

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalHormones and Cancer
Volume1
Issue number5
DOIs
StatePublished - Oct 1 2010

Keywords

  • Androgen
  • Androgen ablation therapy
  • Prostate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

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