Androgen action during prostate carcinogenesis

Diping Wang, Donald J. Tindall

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Scopus citations

Abstract

Androgens are critical for normal prostate development and function, as well as prostate cancer initiation and progression. Androgens function mainly by regulating target gene expression through the androgen receptor (AR). Many studies have shown that androgen-AR signaling exerts actions on key events during prostate carcinogenesis. In this review, androgen action in distinct aspects of prostate carcinogenesis, including (i) cell proliferation, (ii) cell apoptosis, and (iii) prostate cancer metastasis will be discussed.

Original languageEnglish (US)
Title of host publicationAndrogen Action
Subtitle of host publicationMethods and Protocols
EditorsFahri Saatcioglu
Pages25-44
Number of pages20
DOIs
StatePublished - Sep 23 2011

Publication series

NameMethods in Molecular Biology
Volume776
ISSN (Print)1064-3745

Keywords

  • androgen metabolism
  • Androgen receptor
  • androgen signaling
  • castration-resistant prostate cancer
  • prostate cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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