Anatomic site-specific disparities in survival outcomes for penile squamous cell carcinoma

Mark D. Tyson, David A. Etzioni, Eric S. Wisenbaugh, Paul E. Andrews, Mitchell R Humphreys, Robert G. Ferrigni, Scott K. Swanson, Erik P Castle

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To identify the predictors of cancer-specific mortality of penile squamous cell carcinoma (PSCC) using a population-based database. Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results registry, we performed a time-to-event analysis to determine which clinical parameters were useful in predicting cancer-specific mortality. Results: Our cohort consisted of 2515 cases of PSCC diagnosed from 1973 to 2007. The patients were divided into 2 groups: primary tumors of the prepuce (n = 722) and primary tumors of the glans, body, and overlapping lesions of the skin (n = 1793). The median follow-up for the cohort was 39 months (range 1-411). Compared with tumors of the prepuce, tumors of the body (hazard ratio 1.61, 95% confidence interval 1.00-2.60, P =.05) and overlapping tumors of the skin (hazard ratio 1.79, 95% confidence interval 1.13-2.83, P =.01) had a greater risk of cancer-specific mortality, even when controlling for age, Surveillance, Epidemiology, and End Results stage, and tumor grade. Furthermore, the disease-specific 10-year survival rate of those with preputial tumors was 89.4% compared with 78.7% for the other 3 groups combined (P <.0001). Conclusion: Anatomic site-specific disparities for PSCC survival appear to exist. Patients diagnosed with PSCC of the prepuce have greater overall long-term disease-specific survival than patients with primary tumors elsewhere.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
JournalUrology
Volume79
Issue number4
DOIs
StatePublished - Apr 2012

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Squamous Cell Carcinoma
Survival
Neoplasms
Mortality
Epidemiology
Confidence Intervals
Skin
National Cancer Institute (U.S.)
Registries
Cell Survival
Survival Rate
Databases

ASJC Scopus subject areas

  • Urology

Cite this

Anatomic site-specific disparities in survival outcomes for penile squamous cell carcinoma. / Tyson, Mark D.; Etzioni, David A.; Wisenbaugh, Eric S.; Andrews, Paul E.; Humphreys, Mitchell R; Ferrigni, Robert G.; Swanson, Scott K.; Castle, Erik P.

In: Urology, Vol. 79, No. 4, 04.2012, p. 804-808.

Research output: Contribution to journalArticle

Tyson, MD, Etzioni, DA, Wisenbaugh, ES, Andrews, PE, Humphreys, MR, Ferrigni, RG, Swanson, SK & Castle, EP 2012, 'Anatomic site-specific disparities in survival outcomes for penile squamous cell carcinoma', Urology, vol. 79, no. 4, pp. 804-808. https://doi.org/10.1016/j.urology.2011.12.047
Tyson, Mark D. ; Etzioni, David A. ; Wisenbaugh, Eric S. ; Andrews, Paul E. ; Humphreys, Mitchell R ; Ferrigni, Robert G. ; Swanson, Scott K. ; Castle, Erik P. / Anatomic site-specific disparities in survival outcomes for penile squamous cell carcinoma. In: Urology. 2012 ; Vol. 79, No. 4. pp. 804-808.
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abstract = "Objective: To identify the predictors of cancer-specific mortality of penile squamous cell carcinoma (PSCC) using a population-based database. Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results registry, we performed a time-to-event analysis to determine which clinical parameters were useful in predicting cancer-specific mortality. Results: Our cohort consisted of 2515 cases of PSCC diagnosed from 1973 to 2007. The patients were divided into 2 groups: primary tumors of the prepuce (n = 722) and primary tumors of the glans, body, and overlapping lesions of the skin (n = 1793). The median follow-up for the cohort was 39 months (range 1-411). Compared with tumors of the prepuce, tumors of the body (hazard ratio 1.61, 95{\%} confidence interval 1.00-2.60, P =.05) and overlapping tumors of the skin (hazard ratio 1.79, 95{\%} confidence interval 1.13-2.83, P =.01) had a greater risk of cancer-specific mortality, even when controlling for age, Surveillance, Epidemiology, and End Results stage, and tumor grade. Furthermore, the disease-specific 10-year survival rate of those with preputial tumors was 89.4{\%} compared with 78.7{\%} for the other 3 groups combined (P <.0001). Conclusion: Anatomic site-specific disparities for PSCC survival appear to exist. Patients diagnosed with PSCC of the prepuce have greater overall long-term disease-specific survival than patients with primary tumors elsewhere.",
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