Anaphylaxis

Lorenzo Hernandez, Sarah Papalia, George G A Pujalte

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Anaphylaxis is an acute, systemic reaction mediated by immunoglobulin E hypersensitivity. Release of bioactive factors causes vasodilation and bronchiole constriction that can lead to hypotensive shock and asphyxiation. Differential diagnosis includes acute asthma, localized angioedema, syncope, and anxiety/panic attacks. Diagnostic tests lack specificity. Clinical diagnosis is based on demonstration of specific airway or cardiovascular compromise within proximity of allergen exposure. Treatment includes epinephrine, antihistamines, fluid resuscitation, and airway management. Prevention focuses on awareness/avoidance of triggers, implementation of personalized action plans, as well as immune modulation by desensitization in a closely controlled setting where available.

Original languageEnglish (US)
Pages (from-to)477-485
Number of pages9
JournalPrimary Care - Clinics in Office Practice
Volume43
Issue number3
DOIs
StatePublished - Sep 1 2016

Fingerprint

Bronchioles
Angioedema
Airway Management
Panic Disorder
Histamine Antagonists
Asphyxia
Syncope
Anaphylaxis
Routine Diagnostic Tests
Constriction
Vasodilation
Resuscitation
Allergens
Immunoglobulin E
Epinephrine
Shock
Hypersensitivity
Differential Diagnosis
Asthma
Anxiety

Keywords

  • Allergen
  • Anaphylaxis
  • Angioedema
  • Bronchospasm
  • Epinephrine
  • Hypersensitivity
  • IgE
  • Shock

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Hernandez, L., Papalia, S., & Pujalte, G. G. A. (2016). Anaphylaxis. Primary Care - Clinics in Office Practice, 43(3), 477-485. https://doi.org/10.1016/j.pop.2016.04.002

Anaphylaxis. / Hernandez, Lorenzo; Papalia, Sarah; Pujalte, George G A.

In: Primary Care - Clinics in Office Practice, Vol. 43, No. 3, 01.09.2016, p. 477-485.

Research output: Contribution to journalReview article

Hernandez, L, Papalia, S & Pujalte, GGA 2016, 'Anaphylaxis', Primary Care - Clinics in Office Practice, vol. 43, no. 3, pp. 477-485. https://doi.org/10.1016/j.pop.2016.04.002
Hernandez L, Papalia S, Pujalte GGA. Anaphylaxis. Primary Care - Clinics in Office Practice. 2016 Sep 1;43(3):477-485. https://doi.org/10.1016/j.pop.2016.04.002
Hernandez, Lorenzo ; Papalia, Sarah ; Pujalte, George G A. / Anaphylaxis. In: Primary Care - Clinics in Office Practice. 2016 ; Vol. 43, No. 3. pp. 477-485.
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