Analyzing the "Correct" Endpoint

Pamela J. Atherton, Paul J. Novotny, Angelina D. Tan, Jeff A. Sloan

Research output: Contribution to journalArticlepeer-review

Abstract

The choice of QOL endpoints for a study should be based on which score will most likely change if the treatment is favorable. How the QOL change is calculated should be based on the expected amount of missing data, how many time points data will be collected, and whether extreme outliers in the scores impact results. The study should have sufficient power to detect a meaningful difference between arms (typically 10 points on a 0-100 point scale) in the chosen QOL endpoint. At the conclusion of a study, several secondary endpoints can be analyzed which can provide additional information and confirm primary endpoint results.

Original languageEnglish (US)
Pages (from-to)283-297
Number of pages15
JournalCurrent Problems in Cancer
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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