Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population

E. Boerwinkle, Stephen T Turner, Richard M Weinshilboum, M. Johnson, E. Richelson, C. F. Sing

Research output: Contribution to journalArticle

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Abstract

Numerous studies of sodium-lithium countertransport (Na-Li CNT) have reported higher rates in essential hypertensives versus normotensive controls. We studied the distribution and the mode of inheritance of Na-Li CNT using a sample of 238 unrelated individuals and a sample of 245 individuals in 50 pedigrees all sampled from the population at large. The distribution of Na-Li CNT is continuous and bimodal. Our results indicate that there is a large genetic contribution to the distribution of Na-Li CNT. The hypothesis that the effect that caused bimodality is tramsmitted from generation to generation is supported by the fit to these data of a restricted transmission model with τ2 = 0.749. We hypothesize that this deviation of τ2 from its Mendelian expectancy may be attributable to heterogeneity in the etiology of the bimodality in the Na-Li CNT distribution in the population at large.

Original languageEnglish (US)
Pages (from-to)365-378
Number of pages14
JournalGenetic Epidemiology
Volume3
Issue number5
DOIs
StatePublished - 1986

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Pedigree
Lithium
Erythrocytes
Sodium
Demography
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population. / Boerwinkle, E.; Turner, Stephen T; Weinshilboum, Richard M; Johnson, M.; Richelson, E.; Sing, C. F.

In: Genetic Epidemiology, Vol. 3, No. 5, 1986, p. 365-378.

Research output: Contribution to journalArticle

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