Analysis of the copulsatility of anterior pituitary hormones

Johannes D. Veldhuis, Michael L. Johnson, Eugene Seneta

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


We have used combinatorial algebra and computer simulations to calculate expected means, variances, and probabilities of hormone-peak coincidences in 2 or more endocrine pulse series. We illustrate application of this conditional probability analysis to pulsatile LH, FSH, and/or PRL data. We observed that 1) serum LH and FSH pulses in 14 young men were randomly associated on different days (P > 0.10), but highly synchronized on any given day (P < 0.0001); 2) serum LH and FSH (P < 0.0001), LH and PRL (P = 0.023), and FSH and PRL (P = 0.0003) peaks were significantly coupled in healthy postmenopausal women; and 3) the number of triple coincidences among LH, FSH, and PRL release episodes in postmenopausal women significantly exceeded chance expectations (P < 0.0001). We conclude that suitable statistical coincidence analysis can offer an informative tool with which to evaluate nonrandom event concordance in endocrine investigations, such as clinical studies of the temporally coordinated release of anterior pituitary hormones.

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Sep 1991

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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