Analysis of tauopathies with transgenic mice

Mike Hutton, Jada Lewis, Dennis Dickson, Shu Hui Yen, Eileen McGowan

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

Intraneuronal filamentous inclusions composed of the microtubule-associated protein tau are a feature of several neurodegenerative diseases (including Alzheimer's disease) known as tauopathies. A pivotal finding was the identification in 1998 of mutations in tau associated with frontotemporal dementia with parkinsonism linked to chromosome 17. This demonstrated that tau dysfunction is sufficient to cause neurodegeneration, and indicated that tau is likely to play a crucial role in the pathogenesis of other tauopathies. However, the mechanism by which tau filamentous lesions form and their role in neurodegeneration remains uncertain. Recent progress in the development of transgenic mouse models of human tauopathy is allowing these questions to be addressed.

Original languageEnglish (US)
Pages (from-to)467-470
Number of pages4
JournalTrends in Molecular Medicine
Volume7
Issue number10
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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