Original language | English (US) |
---|---|
Article number | 45511 |
Journal | JAMA Network Open |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jan 27 2022 |
ASJC Scopus subject areas
- General Medicine
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In: JAMA Network Open, Vol. 5, No. 1, 45511, 27.01.2022.
Research output: Contribution to journal › Letter › peer-review
}
TY - JOUR
T1 - Analysis of Registered Clinical Trials in Surgical Oncology, 2008-2020
AU - Wong, Bonnie O.
AU - Perera, Nirosha D.
AU - Shen, Jolie Z.
AU - Turner, Brandon E.
AU - Litt, Henry K.
AU - Mahipal, Amit
AU - Wren, Sherry M.
N1 - Funding Information: Although surgical interventions are crucial to treating patients with cancer and determining optimal surgical approaches improves outcomes, there is a paucity of surgical oncology trials. Between 2008 and 2020, only 7.6% of oncology clinical trials investigated surgical interventions, which is lower than previously reported1 and reflects low proportions of cancer research involving surgery worldwide.2 Study limitations included being restricted to registered trials and dependent on the accuracy of reporting in the ClinicalTrial.gov database. Studying surgical interventions can be challenging because of limited funding, training, or support for clinical investigators.5 Learning from the successes of seminal colorectal and gastric cancer trials, increased surgeon involvement in cooperative research groups (eg, Alliance, NRG Oncology) would advance the field. Development of additional cooperative research groups for understudied neoplasm sites may also increase involvement of more surgical specialties. With limited surgical oncology trials, trial quality and timely result reporting are crucial. Trials funded by the US government had the lowest hazard of early discontinuation, thus increased support by the National Cancer Institute and other US government funding will address challenges, such as insufficient long-term funding and inadequate accrual of patients, which may occur with industry or academic funding. Increasingly, surgical clinical trials originate from outside of the US.6 Advocacy for US government funds for surgical oncology trials could improve cancer care and allow the US to continue contributing to surgical oncology advances.
PY - 2022/1/27
Y1 - 2022/1/27
UR - http://www.scopus.com/inward/record.url?scp=85123900979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123900979&partnerID=8YFLogxK
U2 - 10.1001/jamanetworkopen.2021.45511
DO - 10.1001/jamanetworkopen.2021.45511
M3 - Letter
C2 - 35084485
AN - SCOPUS:85123900979
SN - 2574-3805
VL - 5
JO - JAMA Network Open
JF - JAMA Network Open
IS - 1
M1 - 45511
ER -