Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: Relationships and prognostic value

Julie M Cunningham, David W. Kimmel, Bernd W. Scheithauer, Judith R. O'Fallon, Paul J. Novotny, Robert Brian Jenkins

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequently in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalJournal of Neurosurgery
Volume86
Issue number1
StatePublished - Jan 1997

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Astrocytoma
Proliferating Cell Nuclear Antigen
Neoplasms
Aneuploidy
Glioma
Paraffin
Flow Cytometry
Chromosomes
Survival

Keywords

  • glioma
  • MIB-1
  • p53
  • proliferating cell nuclear antigen

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin : Relationships and prognostic value. / Cunningham, Julie M; Kimmel, David W.; Scheithauer, Bernd W.; O'Fallon, Judith R.; Novotny, Paul J.; Jenkins, Robert Brian.

In: Journal of Neurosurgery, Vol. 86, No. 1, 01.1997, p. 121-130.

Research output: Contribution to journalArticle

Cunningham, Julie M ; Kimmel, David W. ; Scheithauer, Bernd W. ; O'Fallon, Judith R. ; Novotny, Paul J. ; Jenkins, Robert Brian. / Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin : Relationships and prognostic value. In: Journal of Neurosurgery. 1997 ; Vol. 86, No. 1. pp. 121-130.
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