TY - JOUR
T1 - Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin
T2 - Relationships and prognostic value
AU - Cunningham, Julie M.
AU - Kimmel, David W.
AU - Scheithauer, Bernd W.
AU - O'Fallon, Judith R.
AU - Novotny, Paul J.
AU - Jenkins, Robert B.
PY - 1997/1
Y1 - 1997/1
N2 - Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequently in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.
AB - Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequently in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.
KW - MIB-1
KW - glioma
KW - p53
KW - proliferating cell nuclear antigen
UR - http://www.scopus.com/inward/record.url?scp=0031033359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031033359&partnerID=8YFLogxK
U2 - 10.3171/jns.1997.86.1.0121
DO - 10.3171/jns.1997.86.1.0121
M3 - Article
C2 - 8988090
AN - SCOPUS:0031033359
SN - 0022-3085
VL - 86
SP - 121
EP - 130
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 1
ER -