Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type

Evelyn A. Reynolds, Katherine Tierney, Gary Keeney, Juan C. Felix, Amy L. Weaver, Lynda D. Roman, William Arthur Cliby

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To estimate the risk of metastatic disease in microinvasive adenocarcinoma of the cervix in a large cohort. Methods: Thirty-six cases were identified from the Mayo Clinic health information database, and 30 cases were identified using the University of Southern California gynecologic oncology patient database. Histopathology was reviewed by a single pathologist at each institution to confirm histologic subtype and grade of tumor, depth of invasion, linear extent of the tumor, the presence or absence of lymphovascular space invasion, margin status, parametrial involvement, and the presence of nodal metastasis. Results: Fifty-two patients had stage IA1 cancers and 14 had stage IA2 cancers. Therapy ranged from cold knife conization to radical hysterectomy with lymphadenectomy. No parametrial involvement was noted in any of the patients who underwent parametrial resection. One patient with stage IA1 cancer had micrometastasis to a pelvic lymph node. No recurrences were noted with an average follow-up of 80 months. Conclusion: The management of microinvasive adenocarcinoma remains controversial, and radical therapy is applied more frequently to microinvasive adenocarcinoma than microinvasive squamous cell carcinoma of the cervix. The risk of extracervical disease is low and the risk of recurrence is not affected by the radicality of resection. Our data suggest that microinvasive adenocarcinoma is amenable to treatment with nonradical surgery.

Original languageEnglish (US)
Pages (from-to)1150-1157
Number of pages8
JournalObstetrics and Gynecology
Volume116
Issue number5
DOIs
StatePublished - 2010

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Cervix Uteri
Adenocarcinoma
Neoplasms
Databases
Conization
Therapeutics
Recurrence
Neoplasm Micrometastasis
Cryotherapy
Lymph Node Excision
Hysterectomy
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Health

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type. / Reynolds, Evelyn A.; Tierney, Katherine; Keeney, Gary; Felix, Juan C.; Weaver, Amy L.; Roman, Lynda D.; Cliby, William Arthur.

In: Obstetrics and Gynecology, Vol. 116, No. 5, 2010, p. 1150-1157.

Research output: Contribution to journalArticle

Reynolds, Evelyn A. ; Tierney, Katherine ; Keeney, Gary ; Felix, Juan C. ; Weaver, Amy L. ; Roman, Lynda D. ; Cliby, William Arthur. / Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 5. pp. 1150-1157.
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