TY - JOUR
T1 - Analysis of non‐Hodgkin's lymphomas with nodular and favorable histologies, stages I and II
AU - Paryani, Shyam B.
AU - Hoppe, Richard T.
AU - Cox, Richard S.
AU - Colby, Thomas V.
AU - Rosenberg, Saul A.
AU - Kaplan, Henry S.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1983/12/15
Y1 - 1983/12/15
N2 - Between 1961 and 1980, 124 patients with Stages I and II nodular lymphocytic poorly differentiated (NLPD), nodular mixed histiocytic‐lymphocytic (NM), nodular histiocytic (NH), or diffuse well‐differentiated lymphocytic (DLWD) lymphoma according to the Rappaport classification were treated at Stanford University. Initial staging studies included lymphangiography in 91%, bone marrow biopsy in 93%, and diagnostic or staging laparotomy in 41% of patients. All patients were treated with megavoltage irradiation to either involved field (IF), extended field (EF), or total lymphoid fields (TLI) to a total dose of 3500–5000 rad. Median follow‐up was 5.5 years. Kaplan‐Meier actuarial survival at 5, 10, and 15 years was 84%, 68%, and 42%, respectively. Freedom from relapse at 5 and 10 years was 62% and 54%, respectively. In addition, there was a flattening of the relapse curve suggesting cure of approximately 50% of patients. Patients with NH had a significantly poorer survival (P = 0.03) while there were no differences among the other histologic groups. Freedom from relapse was higher in patients treated with TLI compared with those treated with IF or EF. However, a prospective study of 20 patients who all underwent staging laparotomy and were randomized to treatment with either IF or TLI revealed no significant difference in either survival or freedom from relapse. Utilizing multivariate analysis for the entire group, important prognostic factors included age, stage, histologic subtype, and treatment field. Cancer 52:2300‐2307, 1983.
AB - Between 1961 and 1980, 124 patients with Stages I and II nodular lymphocytic poorly differentiated (NLPD), nodular mixed histiocytic‐lymphocytic (NM), nodular histiocytic (NH), or diffuse well‐differentiated lymphocytic (DLWD) lymphoma according to the Rappaport classification were treated at Stanford University. Initial staging studies included lymphangiography in 91%, bone marrow biopsy in 93%, and diagnostic or staging laparotomy in 41% of patients. All patients were treated with megavoltage irradiation to either involved field (IF), extended field (EF), or total lymphoid fields (TLI) to a total dose of 3500–5000 rad. Median follow‐up was 5.5 years. Kaplan‐Meier actuarial survival at 5, 10, and 15 years was 84%, 68%, and 42%, respectively. Freedom from relapse at 5 and 10 years was 62% and 54%, respectively. In addition, there was a flattening of the relapse curve suggesting cure of approximately 50% of patients. Patients with NH had a significantly poorer survival (P = 0.03) while there were no differences among the other histologic groups. Freedom from relapse was higher in patients treated with TLI compared with those treated with IF or EF. However, a prospective study of 20 patients who all underwent staging laparotomy and were randomized to treatment with either IF or TLI revealed no significant difference in either survival or freedom from relapse. Utilizing multivariate analysis for the entire group, important prognostic factors included age, stage, histologic subtype, and treatment field. Cancer 52:2300‐2307, 1983.
UR - http://www.scopus.com/inward/record.url?scp=0021051972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021051972&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19831215)52:12<2300::AID-CNCR2820521224>3.0.CO;2-Y
DO - 10.1002/1097-0142(19831215)52:12<2300::AID-CNCR2820521224>3.0.CO;2-Y
M3 - Article
C2 - 6416664
AN - SCOPUS:0021051972
SN - 0008-543X
VL - 52
SP - 2300
EP - 2307
JO - Cancer
JF - Cancer
IS - 12
ER -