TY - JOUR
T1 - Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs
T2 - Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins
AU - Veldhuis, Johannes D.
AU - Faunt, Lindsay M.
AU - Johnson, Michael L.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.
AB - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.
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U2 - 10.1016/S0076-6879(94)40055-5
DO - 10.1016/S0076-6879(94)40055-5
M3 - Article
C2 - 7823838
AN - SCOPUS:0028674283
VL - 240
SP - 349
EP - 377
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
IS - C
ER -