TY - JOUR
T1 - Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs
T2 - Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins
AU - Veldhuis, Johannes D.
AU - Faunt, Lindsay M.
AU - Johnson, Michael L.
N1 - Funding Information:
We thank Patsy Craig for skillful preparation of the manuscript and Paula P. Azimi for the artwork. This work was supported in part by National Institutes of Health Grant RR 00847 to the Clinical Research Center of the University of Virginia, Research Career Development Award 1 KO4 HD00634 (J.D.V.), NIH Grant GM-28928 (M.L.J.), the Diabetes and Endocrinology Research Center Grant NIH DK-38942, the NIH-supported Clinfo Data Reduction Systems, the Pratt Foundation, the University of Virginia Academic Enhancement Fund, and the National Science Foundation Center for Biological Timing (NSF Grant DIR89-20162).
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.
AB - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.
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U2 - 10.1016/S0076-6879(94)40055-5
DO - 10.1016/S0076-6879(94)40055-5
M3 - Article
C2 - 7823838
AN - SCOPUS:0028674283
VL - 240
SP - 349
EP - 377
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
IS - C
ER -