Abstract
Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 349-377 |
| Number of pages | 29 |
| Journal | Methods in enzymology |
| Volume | 240 |
| Issue number | C |
| DOIs | |
| State | Published - Jan 1 1994 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
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Veldhuis, J. D., Faunt, L. M., & Johnson, M. L. (1994). Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods in enzymology, 240(C), 349-377. https://doi.org/10.1016/S0076-6879(94)40055-5