Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

Johannes D. Veldhuis; Lindsay M. Faunt; Michael L. Johnson

doi:10.1016/S0076-6879(94)40055-5

Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

Johannes D. Veldhuis, Lindsay M. Faunt, Michael L. Johnson

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.

Original language	English (US)
Pages (from-to)	349-377
Number of pages	29
Journal	Methods in enzymology
Volume	240
Issue number	C
DOIs	https://doi.org/10.1016/S0076-6879(94)40055-5
State	Published - Jan 1 1994

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1016/S0076-6879(94)40055-5

Fingerprint Dive into the research topics of 'Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins'. Together they form a unique fingerprint.

Cite this

Veldhuis, J. D., Faunt, L. M., & Johnson, M. L. (1994). Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods in enzymology, 240(C), 349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs : Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. / Veldhuis, Johannes D.; Faunt, Lindsay M.; Johnson, Michael L.

In: Methods in enzymology, Vol. 240, No. C, 01.01.1994, p. 349-377.

Research output: Contribution to journal › Article › peer-review

Veldhuis, JD, Faunt, LM & Johnson, ML 1994, 'Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins', Methods in enzymology, vol. 240, no. C, pp. 349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

Veldhuis JD, Faunt LM, Johnson ML. Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods in enzymology. 1994 Jan 1;240(C):349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

Veldhuis, Johannes D. ; Faunt, Lindsay M. ; Johnson, Michael L. / Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs : Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. In: Methods in enzymology. 1994 ; Vol. 240, No. C. pp. 349-377.

@article{7f44445fc9d54ed6960c95485d1ac5d3,

title = "Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins",

abstract = "Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.",

author = "Veldhuis, {Johannes D.} and Faunt, {Lindsay M.} and Johnson, {Michael L.}",

year = "1994",

month = jan,

day = "1",

doi = "10.1016/S0076-6879(94)40055-5",

language = "English (US)",

volume = "240",

pages = "349--377",

journal = "Methods in Enzymology",

issn = "0076-6879",

number = "C",

}

TY - JOUR

T1 - Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs

T2 - Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

AU - Veldhuis, Johannes D.

AU - Faunt, Lindsay M.

AU - Johnson, Michael L.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.

AB - Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.

UR - http://www.scopus.com/inward/record.url?scp=0028674283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028674283&partnerID=8YFLogxK

U2 - 10.1016/S0076-6879(94)40055-5

DO - 10.1016/S0076-6879(94)40055-5

M3 - Article

C2 - 7823838

AN - SCOPUS:0028674283

VL - 240

SP - 349

EP - 377

JO - Methods in Enzymology

JF - Methods in Enzymology

SN - 0076-6879

IS - C

ER -