Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

Johannes D Veldhuis, L. M. Faunt, M. L. Johnson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.

Original languageEnglish (US)
Pages (from-to)349-377
Number of pages29
JournalMethods in Enzymology
Volume240
DOIs
StatePublished - 1994
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry

Cite this