Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

Johannes D Veldhuis; L. M. Faunt; M. L. Johnson

doi:10.1016/S0076-6879(94)40055-5

Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins

Johannes D Veldhuis, L. M. Faunt, M. L. Johnson

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicitly to test relevant hypotheses of ligand binding and clearance.

Original language	English (US)
Pages (from-to)	349-377
Number of pages	29
Journal	Methods in Enzymology
Volume	240
DOIs	https://doi.org/10.1016/S0076-6879(94)40055-5
State	Published - 1994
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry

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Veldhuis, J. D., Faunt, L. M., & Johnson, M. L. (1994). Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods in Enzymology, 240, 349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs : Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. / Veldhuis, Johannes D; Faunt, L. M.; Johnson, M. L.

In: Methods in Enzymology, Vol. 240, 1994, p. 349-377.

Research output: Contribution to journal › Article

Veldhuis, JD, Faunt, LM & Johnson, ML 1994, 'Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins', Methods in Enzymology, vol. 240, pp. 349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

Veldhuis JD, Faunt LM, Johnson ML. Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins. Methods in Enzymology. 1994;240:349-377. https://doi.org/10.1016/S0076-6879(94)40055-5

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10.1016/S0076-6879(94)40055-5