Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity

Gabriele Spina, Martijn A. Spruit, Jennifer Alison, Roberto P Benzo, Peter M A Calverley, Christian F. Clarenbach, Richard W. Costello, David Donaire-Gonzalez, Selina Dürr, Judith Garcia-Aymerich, Arnoldus J R van Gestel, Marco Gramm, Nidia A. Hernandes, Kylie Hill, Nicholas S. Hopkinson, Diana Jarreta, Malcolm Kohler, Anne M. Kirsten, Jörg D. Leuppi, Helgo MagnussenFrançois Maltais, William D C Man, Zoe J. McKeough, Rafael Mesquita, David Miedinger, Fabio Pitta, Sally J. Singh, Frank W J M Smeenk, Ruth Tal-Singer, Barbara Vagaggini, Benjamin Waschki, Henrik Watz, Emiel F M Wouters, Stefanie Zogg, Albertus C. den Brinker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied. Aims To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity. Methods Data were analysed from 932 patients with COPD (66% male, 66.4±8.3 years, FEV1% predicted=50.8±20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients' subsequent daytime physical activity. Results Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts ≥225 min, sleep efficiency ≥91% and time spent awake after sleep onset <57 min) spent significantly more time in light (p<0.01) and moderate-to-vigorous physical activity (p<0.01). Conclusions There is a relationship between measures of sleep in patients with COPD and the amount of activity they undertake during the waking day. Identifying groups with specific sleep characteristics may be useful information when designing physical activityenhancing interventions.

Original languageEnglish (US)
JournalThorax
DOIs
StateAccepted/In press - Jan 12 2017

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Chronic Obstructive Pulmonary Disease
Sleep
Exercise
Dyspnea
Aptitude
Quality of Life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Spina, G., Spruit, M. A., Alison, J., Benzo, R. P., Calverley, P. M. A., Clarenbach, C. F., ... den Brinker, A. C. (Accepted/In press). Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. Thorax. https://doi.org/10.1136/thoraxjnl-2016-208900

Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. / Spina, Gabriele; Spruit, Martijn A.; Alison, Jennifer; Benzo, Roberto P; Calverley, Peter M A; Clarenbach, Christian F.; Costello, Richard W.; Donaire-Gonzalez, David; Dürr, Selina; Garcia-Aymerich, Judith; van Gestel, Arnoldus J R; Gramm, Marco; Hernandes, Nidia A.; Hill, Kylie; Hopkinson, Nicholas S.; Jarreta, Diana; Kohler, Malcolm; Kirsten, Anne M.; Leuppi, Jörg D.; Magnussen, Helgo; Maltais, François; Man, William D C; McKeough, Zoe J.; Mesquita, Rafael; Miedinger, David; Pitta, Fabio; Singh, Sally J.; Smeenk, Frank W J M; Tal-Singer, Ruth; Vagaggini, Barbara; Waschki, Benjamin; Watz, Henrik; Wouters, Emiel F M; Zogg, Stefanie; den Brinker, Albertus C.

In: Thorax, 12.01.2017.

Research output: Contribution to journalArticle

Spina, G, Spruit, MA, Alison, J, Benzo, RP, Calverley, PMA, Clarenbach, CF, Costello, RW, Donaire-Gonzalez, D, Dürr, S, Garcia-Aymerich, J, van Gestel, AJR, Gramm, M, Hernandes, NA, Hill, K, Hopkinson, NS, Jarreta, D, Kohler, M, Kirsten, AM, Leuppi, JD, Magnussen, H, Maltais, F, Man, WDC, McKeough, ZJ, Mesquita, R, Miedinger, D, Pitta, F, Singh, SJ, Smeenk, FWJM, Tal-Singer, R, Vagaggini, B, Waschki, B, Watz, H, Wouters, EFM, Zogg, S & den Brinker, AC 2017, 'Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity', Thorax. https://doi.org/10.1136/thoraxjnl-2016-208900
Spina, Gabriele ; Spruit, Martijn A. ; Alison, Jennifer ; Benzo, Roberto P ; Calverley, Peter M A ; Clarenbach, Christian F. ; Costello, Richard W. ; Donaire-Gonzalez, David ; Dürr, Selina ; Garcia-Aymerich, Judith ; van Gestel, Arnoldus J R ; Gramm, Marco ; Hernandes, Nidia A. ; Hill, Kylie ; Hopkinson, Nicholas S. ; Jarreta, Diana ; Kohler, Malcolm ; Kirsten, Anne M. ; Leuppi, Jörg D. ; Magnussen, Helgo ; Maltais, François ; Man, William D C ; McKeough, Zoe J. ; Mesquita, Rafael ; Miedinger, David ; Pitta, Fabio ; Singh, Sally J. ; Smeenk, Frank W J M ; Tal-Singer, Ruth ; Vagaggini, Barbara ; Waschki, Benjamin ; Watz, Henrik ; Wouters, Emiel F M ; Zogg, Stefanie ; den Brinker, Albertus C. / Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. In: Thorax. 2017.
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title = "Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity",
abstract = "Background Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied. Aims To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity. Methods Data were analysed from 932 patients with COPD (66{\%} male, 66.4±8.3 years, FEV1{\%} predicted=50.8±20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients' subsequent daytime physical activity. Results Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts ≥225 min, sleep efficiency ≥91{\%} and time spent awake after sleep onset <57 min) spent significantly more time in light (p<0.01) and moderate-to-vigorous physical activity (p<0.01). Conclusions There is a relationship between measures of sleep in patients with COPD and the amount of activity they undertake during the waking day. Identifying groups with specific sleep characteristics may be useful information when designing physical activityenhancing interventions.",
author = "Gabriele Spina and Spruit, {Martijn A.} and Jennifer Alison and Benzo, {Roberto P} and Calverley, {Peter M A} and Clarenbach, {Christian F.} and Costello, {Richard W.} and David Donaire-Gonzalez and Selina D{\"u}rr and Judith Garcia-Aymerich and {van Gestel}, {Arnoldus J R} and Marco Gramm and Hernandes, {Nidia A.} and Kylie Hill and Hopkinson, {Nicholas S.} and Diana Jarreta and Malcolm Kohler and Kirsten, {Anne M.} and Leuppi, {J{\"o}rg D.} and Helgo Magnussen and Fran{\cc}ois Maltais and Man, {William D C} and McKeough, {Zoe J.} and Rafael Mesquita and David Miedinger and Fabio Pitta and Singh, {Sally J.} and Smeenk, {Frank W J M} and Ruth Tal-Singer and Barbara Vagaggini and Benjamin Waschki and Henrik Watz and Wouters, {Emiel F M} and Stefanie Zogg and {den Brinker}, {Albertus C.}",
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T1 - Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity

AU - Spina, Gabriele

AU - Spruit, Martijn A.

AU - Alison, Jennifer

AU - Benzo, Roberto P

AU - Calverley, Peter M A

AU - Clarenbach, Christian F.

AU - Costello, Richard W.

AU - Donaire-Gonzalez, David

AU - Dürr, Selina

AU - Garcia-Aymerich, Judith

AU - van Gestel, Arnoldus J R

AU - Gramm, Marco

AU - Hernandes, Nidia A.

AU - Hill, Kylie

AU - Hopkinson, Nicholas S.

AU - Jarreta, Diana

AU - Kohler, Malcolm

AU - Kirsten, Anne M.

AU - Leuppi, Jörg D.

AU - Magnussen, Helgo

AU - Maltais, François

AU - Man, William D C

AU - McKeough, Zoe J.

AU - Mesquita, Rafael

AU - Miedinger, David

AU - Pitta, Fabio

AU - Singh, Sally J.

AU - Smeenk, Frank W J M

AU - Tal-Singer, Ruth

AU - Vagaggini, Barbara

AU - Waschki, Benjamin

AU - Watz, Henrik

AU - Wouters, Emiel F M

AU - Zogg, Stefanie

AU - den Brinker, Albertus C.

PY - 2017/1/12

Y1 - 2017/1/12

N2 - Background Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied. Aims To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity. Methods Data were analysed from 932 patients with COPD (66% male, 66.4±8.3 years, FEV1% predicted=50.8±20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients' subsequent daytime physical activity. Results Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts ≥225 min, sleep efficiency ≥91% and time spent awake after sleep onset <57 min) spent significantly more time in light (p<0.01) and moderate-to-vigorous physical activity (p<0.01). Conclusions There is a relationship between measures of sleep in patients with COPD and the amount of activity they undertake during the waking day. Identifying groups with specific sleep characteristics may be useful information when designing physical activityenhancing interventions.

AB - Background Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied. Aims To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity. Methods Data were analysed from 932 patients with COPD (66% male, 66.4±8.3 years, FEV1% predicted=50.8±20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients' subsequent daytime physical activity. Results Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts ≥225 min, sleep efficiency ≥91% and time spent awake after sleep onset <57 min) spent significantly more time in light (p<0.01) and moderate-to-vigorous physical activity (p<0.01). Conclusions There is a relationship between measures of sleep in patients with COPD and the amount of activity they undertake during the waking day. Identifying groups with specific sleep characteristics may be useful information when designing physical activityenhancing interventions.

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