Analysis of neuroretinal rim distribution and vascular pattern in eyes with presumed large physiological cupping: A comparative study

Flavio Ss Lopes, Syril Dorairaj, Daniela Lm Junqueira, Rafael L. Furlanetto, Luis Gustavo Biteli, Tiago Santos Prata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: To investigate possible differences in neuroretinal rim distribution, vascular pattern, and peripapillary region appearance between eyes with presumed large physiological optic disc cupping (pLPC) and eyes with minimal optic disc excavation. Methods. We prospectively enrolled consecutive subjects with pLPC and individuals with minimal excavation (optic disc excavation within normal limits; control group). All eyes had normal visual fields and untreated intraocular pressure (IOP) <21 mmHg. Eyes with pLPC required vertical cup-to-disc ratio (VCDR) ≥0.6 and ≥30 months of follow-up with no evidence of glaucomatous neuropathy. For controls, VCDR was limited to ≤0.5. We compared ocular signs and characteristics related to the neuroretinal rim distribution, vascular pattern, peripapillary region appearance and disc size between groups. Whenever both eyes were eligible, one was randomly selected for analysis. Results: A total of 74 patients (mean age, 45.6 ± 14.9 years) with pLPC and 45 controls (mean age, 44.8 ± 11.6 years) were enrolled (p = 0.76). Median disc size and VCDR was significantly larger in eyes with pLPC compared to controls (p < 0.01). The proportion of eyes with violation of the ISNT rule, laminar dot sign, nasal shifting of the central vessels, nasal excavation and baring of circumlinear vessel was significantly greater in the eyes with pLPC compared to controls (p < 0.01). There were no significant differences regarding the proportions of eyes with peripapillary atrophy between groups (p < 0.09). Finally, disc size was significantly associated with VCDR (r2 = 0.47, p < 0.01), with an increase of 0.21 in VCDR for each 1 mm2 in disc area. Conclusion: Compared to normal controls, eyes with pLPC may present a higher proportion of optic nerve head findings frequently observed in glaucomatous eyes. This seems to be explained in part by the larger discs found in these eyes. We believe care should be taken while classifying them as glaucomatous or not based solely on these characteristics.

Original languageEnglish (US)
Article number72
JournalBMC Ophthalmology
Volume14
Issue number1
DOIs
StatePublished - May 27 2014

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Blood Vessels
Optic Disk
Nose
Visual Fields
Intraocular Pressure
Atrophy
Control Groups

Keywords

  • Disc size
  • Glaucoma suspect
  • Intraocular pressure
  • Optic disc cup

ASJC Scopus subject areas

  • Ophthalmology

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Analysis of neuroretinal rim distribution and vascular pattern in eyes with presumed large physiological cupping : A comparative study. / Lopes, Flavio Ss; Dorairaj, Syril; Junqueira, Daniela Lm; Furlanetto, Rafael L.; Biteli, Luis Gustavo; Prata, Tiago Santos.

In: BMC Ophthalmology, Vol. 14, No. 1, 72, 27.05.2014.

Research output: Contribution to journalArticle

Lopes, Flavio Ss ; Dorairaj, Syril ; Junqueira, Daniela Lm ; Furlanetto, Rafael L. ; Biteli, Luis Gustavo ; Prata, Tiago Santos. / Analysis of neuroretinal rim distribution and vascular pattern in eyes with presumed large physiological cupping : A comparative study. In: BMC Ophthalmology. 2014 ; Vol. 14, No. 1.
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AU - Furlanetto, Rafael L.

AU - Biteli, Luis Gustavo

AU - Prata, Tiago Santos

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N2 - Background: To investigate possible differences in neuroretinal rim distribution, vascular pattern, and peripapillary region appearance between eyes with presumed large physiological optic disc cupping (pLPC) and eyes with minimal optic disc excavation. Methods. We prospectively enrolled consecutive subjects with pLPC and individuals with minimal excavation (optic disc excavation within normal limits; control group). All eyes had normal visual fields and untreated intraocular pressure (IOP) <21 mmHg. Eyes with pLPC required vertical cup-to-disc ratio (VCDR) ≥0.6 and ≥30 months of follow-up with no evidence of glaucomatous neuropathy. For controls, VCDR was limited to ≤0.5. We compared ocular signs and characteristics related to the neuroretinal rim distribution, vascular pattern, peripapillary region appearance and disc size between groups. Whenever both eyes were eligible, one was randomly selected for analysis. Results: A total of 74 patients (mean age, 45.6 ± 14.9 years) with pLPC and 45 controls (mean age, 44.8 ± 11.6 years) were enrolled (p = 0.76). Median disc size and VCDR was significantly larger in eyes with pLPC compared to controls (p < 0.01). The proportion of eyes with violation of the ISNT rule, laminar dot sign, nasal shifting of the central vessels, nasal excavation and baring of circumlinear vessel was significantly greater in the eyes with pLPC compared to controls (p < 0.01). There were no significant differences regarding the proportions of eyes with peripapillary atrophy between groups (p < 0.09). Finally, disc size was significantly associated with VCDR (r2 = 0.47, p < 0.01), with an increase of 0.21 in VCDR for each 1 mm2 in disc area. Conclusion: Compared to normal controls, eyes with pLPC may present a higher proportion of optic nerve head findings frequently observed in glaucomatous eyes. This seems to be explained in part by the larger discs found in these eyes. We believe care should be taken while classifying them as glaucomatous or not based solely on these characteristics.

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