Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross; Yih Ru Wu; Mei Ching Lee; Manabu Funayama; Meng Ling Chen; Alexandra I. Soto; Ignacio F. Mata; Guey Jen Lee-Chen; Mei Chen Chiung; Michelle Tang; Yi Zhao; Nobutaka Hattori; Matthew J. Farrer; Eng King Tan; Ruey Meei Wu

doi:10.1002/ana.21405

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

Neuroscience

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

Original language	English (US)
Pages (from-to)	88-92
Number of pages	5
Journal	Annals of neurology
Volume	64
Issue number	1
DOIs	https://doi.org/10.1002/ana.21405
State	Published - Jul 2008

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.21405

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title = "Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease",

abstract = "Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.",

author = "Ross, {Owen A.} and Wu, {Yih Ru} and Lee, {Mei Ching} and Manabu Funayama and Chen, {Meng Ling} and Soto, {Alexandra I.} and Mata, {Ignacio F.} and Lee-Chen, {Guey Jen} and Chiung, {Mei Chen} and Michelle Tang and Yi Zhao and Nobutaka Hattori and Farrer, {Matthew J.} and Tan, {Eng King} and Wu, {Ruey Meei}",

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AU - Wu, Yih Ru

AU - Lee, Mei Ching

AU - Funayama, Manabu

AU - Chen, Meng Ling

AU - Soto, Alexandra I.

AU - Mata, Ignacio F.

AU - Lee-Chen, Guey Jen

AU - Chiung, Mei Chen

AU - Tang, Michelle

AU - Zhao, Yi

AU - Hattori, Nobutaka

AU - Farrer, Matthew J.

AU - Tan, Eng King

AU - Wu, Ruey Meei

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AB - Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Abstract

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