Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Joshua N. Sampson, William A. Wheeler, Meredith Yeager, Orestis Panagiotou, Zhaoming Wang, Sonja I. Berndt, Qing Lan, Christian C. Abnet, Laufey T. Amundadottir, Jonine D. Figueroa, Maria Teresa Landi, Lisa Mirabello, Sharon A. Savage, Philip R. Taylor, Immaculata De Vivo, Katherine A. McGlynn, Mark P. Purdue, Preetha Rajaraman, Hans Olov Adami, Anders AhlbomDemetrius Albanes, Maria Fernanda Amary, She Juan An, Ulrika Andersson, Gerald Andriole, Irene L. Andrulis, Emanuele Angelucci, Stephen Maxted Ansell, Cecilia Arici, Bruce K. Armstrong, Alan A. Arslan, Melissa A. Austin, Dalsu Baris, Donald A. Barkauskas, Bryan A. Bassig, Nikolaus Becker, Yolanda Benavente, Simone Benhamou, Christine Berg, David Van Den Berg, Leslie Bernstein, Kimberly A. Bertrand, Brenda M. Birmann, Amanda Black, Tait D. Shanafelt, Paolo Boffetta, Marie Christine Boutron-Ruault, Paige M. Bracci, Louise Brinton, Angela R. Brooks-Wilson, H. Bas Bueno-De-Mesquita, Laurie Burdett, Julie Buring, Mary Ann Butler, Qiuyin Cai, Geraldine Cancel-Tassin, Federico Canzian, Alfredo Carrato, Tania Carreon, Angela Carta, John K C Chan, Ellen T. Chang, Gee Chen Chang, I. Shou Chang, Jiang Chang, Jenny Chang-Claude, Chien Jen Chen, Chih Yi Chen, Chu Chen, Chung Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan Yu Chen, Kun Chieh Chen, Ying Chen, Ying Hsiang Chen, Yi Song Chen, Yuh Min Chen, Li Hsin Chien, María Dolores Chirlaque, Jin Eun Choi, Yi Young Choi, Wong Ho Chow, Charles C. Chung, Jacqueline Clavel, Françoise Clavel-Chapelon, Pierluigi Cocco, Joanne S. Colt, Eva Comperat, Lucia Conde, Joseph M. Connors, David Conti, Victoria K. Cortessis, Michelle Cotterchio, Wendy Cozen, Simon Crouch, Marta Crous-Bou, Olivier Cussenot, Faith G. Davis, Ti Ding, W. Ryan Diver, Miren Dorronsoro, Laure Dossus, Eric J. Duell, Maria Grazia Ennas, Ralph L. Erickson, Maria Feychting, Adrienne M. Flanagan, Lenka Foretova, Joseph F. Fraumeni, Neal D. Freedman, Laura E Beane Freeman, Charles Fuchs, Manuela Gago-Dominguez, Steven Gallinger, Yu Tang Gao, Susan M. Gapstur, Montserrat Garcia-Closas, Reina García-Closas, Randy D. Gascoyne, Julie Gastier-Foster, Mia M. Gaudet, J. Michael Gaziano, Carol Giffen, Graham G. Giles, Edward Giovannucci, Bengt Glimelius, Michael Goggins, Nalan Gokgoz, Alisa M. Goldstein, Richard Gorlick, Myron Gross, Robert Grubb, Jian Gu, Peng Guan, Marc Gunter, Huan Guo, Thomas Matthew Habermann, Christopher A. Haiman, Dina Halai, Goran Hallmans, Manal Hassan, Claudia Hattinger, Qincheng He, Xingzhou He, Kathy Helzlsouer, Brian Henderson, Roger Henriksson, Henrik Hjalgrim, Judith Hoffman-Bolton, Chancellor Hohensee, Theodore R. Holford, Elizabeth A. Holly, Yun Chul Hong, Robert N. Hoover, Pamela L. Horn-Ross, G. M Monawar Hosain, H. Dean Hosgood, Chin Fu Hsiao, Nan Hu, Wei Hu, Zhibin Hu, Ming Shyan Huang, Jose Maria Huerta, Jen Yu Hung, Amy Hutchinson, Peter D. Inskip, Rebecca D. Jackson, Eric J. Jacobs, Mazda Jenab, Hyo Sung Jeon, Bu Tian Ji, Guangfu Jin, Li Jin, Christoffer Johansen, Alison Johnson, Yoo Jin Jung, Rudolph Kaaks, Aruna Kamineni, Eleanor Kane, Chang Hyun Kang, Margaret R. Karagas, Rachel S. Kelly, Kay Tee Khaw, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young Chul Kim, Cari M. Kitahara, Alison P. Klein, Robert J. Klein, Manolis Kogevinas, Takashi Kohno, Laurence N. Kolonel, Charles Kooperberg, Anne Kricker, Vittorio Krogh, Hideo Kunitoh, Robert C. Kurtz, Sun Seog Kweon, Andrea La Croix, Charles Lawrence, Fernando Lecanda, Victor Ho Fun Lee, Donghui Li, Haixin Li, Jihua Li, Yao Jen Li, Yuqing Li, Linda M. Liao, Mark Liebow, Tracy Lightfoot, Wei Yen Lim, Chien Chung Lin, Dongxin Lin, Sara Lindstrom, Martha S. Linet, Brian K. Link, Chenwei Liu, Jianjun Liu, Li Liu, Börje Ljungberg, Josep Lloreta, Simonetta Di Lollo, Daru Lu, Eiluv Lund, Nuria Malats, Satu Mannisto, Loic Le Marchand, Neyssa Marina, Giovanna Masala, Giuseppe Mastrangelo, Keitaro Matsuo, Marc Maynadie, James McKay, Roberta McKean-Cowdin, Mads Melbye, Beatrice S. Melin, Dominique S. Michaud, Tetsuya Mitsudomi, Alain Monnereau, Rebecca Montalvan, Lee E. Moore, Lotte Maxild Mortensen, Alexandra Nieters, Kari E. North, Anne J Novak, Ann L Oberg, Kenneth Offit, In Jae Oh, Sara H. Olson, Domenico Palli, William Pao, In Kyu Park, Jae Yong Park, Kyong Hwa Park, Ana Patiño-Garcia, Sofia Pavanello, Petra H M Peeters, Reury Perng Perng, Ulrike Peters, Gloria M Petersen, Piero Picci, Malcolm C. Pike, Stefano Porru, Jennifer Prescott, Ludmila Prokunina-Olsson, Biyun Qian, You Lin Qiao, Marco Rais, Elio Riboli, Jacques Riby, Harvey A. Risch, Cosmeri Rizzato, Rebecca Rodabough, Eve Roman, Morgan Roupret, Avima M. Ruder, Silvia De Sanjose, Ghislaine Scelo, Alan Schned, Fredrick Schumacher, Kendra Schwartz, Molly Schwenn, Katia Scotlandi, Adeline Seow, Consol Serra, Massimo Serra, Howard D. Sesso, Veronica Wendy Setiawan, Gianluca Severi, Richard K. Severson, Tait D. Shanafelt, Hongbing Shen, Wei Shen, Min Ho Shin, Kouya Shiraishi, Xiao Ou Shu, Afshan Siddiq, Luis Sierrasesúmaga, Alan Dart Loon Sihoe, Christine F. Skibola, Alex Smith, Martyn T. Smith, Melissa C. Southey, John J. Spinelli, Anthony Staines, Meir Stampfer, Marianna C. Stern, Victoria L. Stevens, Rachael S. Stolzenberg-Solomon, Jian Su, Wu Chou Su, Malin Sund, Jae Sook Sung, Sook Whan Sung, Wen Tan, Wei Tang, Adonina Tardón, David Thomas, Carrie A Thompson, Lesley F. Tinker, Roberto Tirabosco, Anne Tjønneland, Ruth C. Travis, Dimitrios Trichopoulos, Fang Yu Tsai, Ying Huang Tsai, Margaret Tucker, Jenny Turner, Claire M. Vajdic, Roel C H Vermeulen, Danylo J. Villano, Paolo Vineis, Jarmo Virtamo, Kala Visvanathan, Jean Wactawski-Wende, Chaoyu Wang, Chih Liang Wang, Jiu Cun Wang, Junwen Wang, Fusheng Wei, Elisabete Weiderpass, George J. Weiner, Stephanie Weinstein, Nicolas Wentzensen, Emily White, Thomas Elmer Witzig, Brian M. Wolpin, Maria Pik Wong, Chen Wu, Guoping Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi Long Wu, Jay S. Wunder, Yong Bing Xiang, Jun Xu, Ping Xu, Pan Chyr Yang, Tsung Ying Yang, Yuanqing Ye, Zhihua Yin, Jun Yokota, Ho Il Yoon, Chong Jen Yu, Herbert Yu, Kai Yu, Jian Min Yuan, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Xu Chao Zhang, Yawei Zhang, Xueying Zhao, Zhenhong Zhao, Hong Zheng, Tongzhang Zheng, Wei Zheng, Baosen Zhou, Meng Zhu, Mariagrazia Zucca, Simina M. Boca, James R Cerhan, Giovanni M. Ferri, Patricia Hartge, Chao Agnes Hsiung, Corrado Magnani, Lucia Miligi, Lindsay M. Morton, Karin E. Smedby, Lauren R. Teras, Joseph Vijai, Sophia S. Wang, Paul Brennan, Neil E. Caporaso, David J. Hunter, Peter Kraft, Nathaniel Rothman, Debra T. Silverman, Susan L Slager, Stephen J. Chanock, Nilanjan Chatterjee

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl 2, on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Original languageEnglish (US)
Article numberdjv279
JournalJournal of the National Cancer Institute
Volume107
Issue number12
DOIs
StatePublished - 2016

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Genome-Wide Association Study
Smoking
Neoplasms
Lung Neoplasms
Confidence Intervals
Population
National Cancer Institute (U.S.)
Lymphoma, Large B-Cell, Diffuse
Environmental Exposure
Osteosarcoma
B-Cell Chronic Lymphocytic Leukemia
Urinary Bladder Neoplasms
Single Nucleotide Polymorphism
Testis
Urinary Bladder
Pediatrics
Kidney
Lung

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Sampson, J. N., Wheeler, W. A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S. I., ... Chatterjee, N. (2016). Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. Journal of the National Cancer Institute, 107(12), [djv279]. https://doi.org/10.1093/jnci/djv279

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. / Sampson, Joshua N.; Wheeler, William A.; Yeager, Meredith; Panagiotou, Orestis; Wang, Zhaoming; Berndt, Sonja I.; Lan, Qing; Abnet, Christian C.; Amundadottir, Laufey T.; Figueroa, Jonine D.; Landi, Maria Teresa; Mirabello, Lisa; Savage, Sharon A.; Taylor, Philip R.; De Vivo, Immaculata; McGlynn, Katherine A.; Purdue, Mark P.; Rajaraman, Preetha; Adami, Hans Olov; Ahlbom, Anders; Albanes, Demetrius; Amary, Maria Fernanda; An, She Juan; Andersson, Ulrika; Andriole, Gerald; Andrulis, Irene L.; Angelucci, Emanuele; Ansell, Stephen Maxted; Arici, Cecilia; Armstrong, Bruce K.; Arslan, Alan A.; Austin, Melissa A.; Baris, Dalsu; Barkauskas, Donald A.; Bassig, Bryan A.; Becker, Nikolaus; Benavente, Yolanda; Benhamou, Simone; Berg, Christine; Van Den Berg, David; Bernstein, Leslie; Bertrand, Kimberly A.; Birmann, Brenda M.; Black, Amanda; Shanafelt, Tait D.; Boffetta, Paolo; Boutron-Ruault, Marie Christine; Bracci, Paige M.; Brinton, Louise; Brooks-Wilson, Angela R.; Bueno-De-Mesquita, H. Bas; Burdett, Laurie; Buring, Julie; Butler, Mary Ann; Cai, Qiuyin; Cancel-Tassin, Geraldine; Canzian, Federico; Carrato, Alfredo; Carreon, Tania; Carta, Angela; Chan, John K C; Chang, Ellen T.; Chang, Gee Chen; Chang, I. Shou; Chang, Jiang; Chang-Claude, Jenny; Chen, Chien Jen; Chen, Chih Yi; Chen, Chu; Chen, Chung Hsing; Chen, Constance; Chen, Hongyan; Chen, Kexin; Chen, Kuan Yu; Chen, Kun Chieh; Chen, Ying; Chen, Ying Hsiang; Chen, Yi Song; Chen, Yuh Min; Chien, Li Hsin; Chirlaque, María Dolores; Choi, Jin Eun; Choi, Yi Young; Chow, Wong Ho; Chung, Charles C.; Clavel, Jacqueline; Clavel-Chapelon, Françoise; Cocco, Pierluigi; Colt, Joanne S.; Comperat, Eva; Conde, Lucia; Connors, Joseph M.; Conti, David; Cortessis, Victoria K.; Cotterchio, Michelle; Cozen, Wendy; Crouch, Simon; Crous-Bou, Marta; Cussenot, Olivier; Davis, Faith G.; Ding, Ti; Diver, W. Ryan; Dorronsoro, Miren; Dossus, Laure; Duell, Eric J.; Ennas, Maria Grazia; Erickson, Ralph L.; Feychting, Maria; Flanagan, Adrienne M.; Foretova, Lenka; Fraumeni, Joseph F.; Freedman, Neal D.; Freeman, Laura E Beane; Fuchs, Charles; Gago-Dominguez, Manuela; Gallinger, Steven; Gao, Yu Tang; Gapstur, Susan M.; Garcia-Closas, Montserrat; García-Closas, Reina; Gascoyne, Randy D.; Gastier-Foster, Julie; Gaudet, Mia M.; Gaziano, J. Michael; Giffen, Carol; Giles, Graham G.; Giovannucci, Edward; Glimelius, Bengt; Goggins, Michael; Gokgoz, Nalan; Goldstein, Alisa M.; Gorlick, Richard; Gross, Myron; Grubb, Robert; Gu, Jian; Guan, Peng; Gunter, Marc; Guo, Huan; Habermann, Thomas Matthew; Haiman, Christopher A.; Halai, Dina; Hallmans, Goran; Hassan, Manal; Hattinger, Claudia; He, Qincheng; He, Xingzhou; Helzlsouer, Kathy; Henderson, Brian; Henriksson, Roger; Hjalgrim, Henrik; Hoffman-Bolton, Judith; Hohensee, Chancellor; Holford, Theodore R.; Holly, Elizabeth A.; Hong, Yun Chul; Hoover, Robert N.; Horn-Ross, Pamela L.; Hosain, G. M Monawar; Hosgood, H. Dean; Hsiao, Chin Fu; Hu, Nan; Hu, Wei; Hu, Zhibin; Huang, Ming Shyan; Huerta, Jose Maria; Hung, Jen Yu; Hutchinson, Amy; Inskip, Peter D.; Jackson, Rebecca D.; Jacobs, Eric J.; Jenab, Mazda; Jeon, Hyo Sung; Ji, Bu Tian; Jin, Guangfu; Jin, Li; Johansen, Christoffer; Johnson, Alison; Jung, Yoo Jin; Kaaks, Rudolph; Kamineni, Aruna; Kane, Eleanor; Kang, Chang Hyun; Karagas, Margaret R.; Kelly, Rachel S.; Khaw, Kay Tee; Kim, Christopher; Kim, Hee Nam; Kim, Jin Hee; Kim, Jun Suk; Kim, Yeul Hong; Kim, Young Tae; Kim, Young Chul; Kitahara, Cari M.; Klein, Alison P.; Klein, Robert J.; Kogevinas, Manolis; Kohno, Takashi; Kolonel, Laurence N.; Kooperberg, Charles; Kricker, Anne; Krogh, Vittorio; Kunitoh, Hideo; Kurtz, Robert C.; Kweon, Sun Seog; La Croix, Andrea; Lawrence, Charles; Lecanda, Fernando; Lee, Victor Ho Fun; Li, Donghui; Li, Haixin; Li, Jihua; Li, Yao Jen; Li, Yuqing; Liao, Linda M.; Liebow, Mark; Lightfoot, Tracy; Lim, Wei Yen; Lin, Chien Chung; Lin, Dongxin; Lindstrom, Sara; Linet, Martha S.; Link, Brian K.; Liu, Chenwei; Liu, Jianjun; Liu, Li; Ljungberg, Börje; Lloreta, Josep; Di Lollo, Simonetta; Lu, Daru; Lund, Eiluv; Malats, Nuria; Mannisto, Satu; Marchand, Loic Le; Marina, Neyssa; Masala, Giovanna; Mastrangelo, Giuseppe; Matsuo, Keitaro; Maynadie, Marc; McKay, James; McKean-Cowdin, Roberta; Melbye, Mads; Melin, Beatrice S.; Michaud, Dominique S.; Mitsudomi, Tetsuya; Monnereau, Alain; Montalvan, Rebecca; Moore, Lee E.; Mortensen, Lotte Maxild; Nieters, Alexandra; North, Kari E.; Novak, Anne J; Oberg, Ann L; Offit, Kenneth; Oh, In Jae; Olson, Sara H.; Palli, Domenico; Pao, William; Park, In Kyu; Park, Jae Yong; Park, Kyong Hwa; Patiño-Garcia, Ana; Pavanello, Sofia; Peeters, Petra H M; Perng, Reury Perng; Peters, Ulrike; Petersen, Gloria M; Picci, Piero; Pike, Malcolm C.; Porru, Stefano; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Qian, Biyun; Qiao, You Lin; Rais, Marco; Riboli, Elio; Riby, Jacques; Risch, Harvey A.; Rizzato, Cosmeri; Rodabough, Rebecca; Roman, Eve; Roupret, Morgan; Ruder, Avima M.; De Sanjose, Silvia; Scelo, Ghislaine; Schned, Alan; Schumacher, Fredrick; Schwartz, Kendra; Schwenn, Molly; Scotlandi, Katia; Seow, Adeline; Serra, Consol; Serra, Massimo; Sesso, Howard D.; Setiawan, Veronica Wendy; Severi, Gianluca; Severson, Richard K.; Shanafelt, Tait D.; Shen, Hongbing; Shen, Wei; Shin, Min Ho; Shiraishi, Kouya; Shu, Xiao Ou; Siddiq, Afshan; Sierrasesúmaga, Luis; Sihoe, Alan Dart Loon; Skibola, Christine F.; Smith, Alex; Smith, Martyn T.; Southey, Melissa C.; Spinelli, John J.; Staines, Anthony; Stampfer, Meir; Stern, Marianna C.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael S.; Su, Jian; Su, Wu Chou; Sund, Malin; Sung, Jae Sook; Sung, Sook Whan; Tan, Wen; Tang, Wei; Tardón, Adonina; Thomas, David; Thompson, Carrie A; Tinker, Lesley F.; Tirabosco, Roberto; Tjønneland, Anne; Travis, Ruth C.; Trichopoulos, Dimitrios; Tsai, Fang Yu; Tsai, Ying Huang; Tucker, Margaret; Turner, Jenny; Vajdic, Claire M.; Vermeulen, Roel C H; Villano, Danylo J.; Vineis, Paolo; Virtamo, Jarmo; Visvanathan, Kala; Wactawski-Wende, Jean; Wang, Chaoyu; Wang, Chih Liang; Wang, Jiu Cun; Wang, Junwen; Wei, Fusheng; Weiderpass, Elisabete; Weiner, George J.; Weinstein, Stephanie; Wentzensen, Nicolas; White, Emily; Witzig, Thomas Elmer; Wolpin, Brian M.; Wong, Maria Pik; Wu, Chen; Wu, Guoping; Wu, Junjie; Wu, Tangchun; Wu, Wei; Wu, Xifeng; Wu, Yi Long; Wunder, Jay S.; Xiang, Yong Bing; Xu, Jun; Xu, Ping; Yang, Pan Chyr; Yang, Tsung Ying; Ye, Yuanqing; Yin, Zhihua; Yokota, Jun; Yoon, Ho Il; Yu, Chong Jen; Yu, Herbert; Yu, Kai; Yuan, Jian Min; Zelenetz, Andrew; Zeleniuch-Jacquotte, Anne; Zhang, Xu Chao; Zhang, Yawei; Zhao, Xueying; Zhao, Zhenhong; Zheng, Hong; Zheng, Tongzhang; Zheng, Wei; Zhou, Baosen; Zhu, Meng; Zucca, Mariagrazia; Boca, Simina M.; Cerhan, James R; Ferri, Giovanni M.; Hartge, Patricia; Hsiung, Chao Agnes; Magnani, Corrado; Miligi, Lucia; Morton, Lindsay M.; Smedby, Karin E.; Teras, Lauren R.; Vijai, Joseph; Wang, Sophia S.; Brennan, Paul; Caporaso, Neil E.; Hunter, David J.; Kraft, Peter; Rothman, Nathaniel; Silverman, Debra T.; Slager, Susan L; Chanock, Stephen J.; Chatterjee, Nilanjan.

In: Journal of the National Cancer Institute, Vol. 107, No. 12, djv279, 2016.

Research output: Contribution to journalArticle

Sampson, JN, Wheeler, WA, Yeager, M, Panagiotou, O, Wang, Z, Berndt, SI, Lan, Q, Abnet, CC, Amundadottir, LT, Figueroa, JD, Landi, MT, Mirabello, L, Savage, SA, Taylor, PR, De Vivo, I, McGlynn, KA, Purdue, MP, Rajaraman, P, Adami, HO, Ahlbom, A, Albanes, D, Amary, MF, An, SJ, Andersson, U, Andriole, G, Andrulis, IL, Angelucci, E, Ansell, SM, Arici, C, Armstrong, BK, Arslan, AA, Austin, MA, Baris, D, Barkauskas, DA, Bassig, BA, Becker, N, Benavente, Y, Benhamou, S, Berg, C, Van Den Berg, D, Bernstein, L, Bertrand, KA, Birmann, BM, Black, A, Shanafelt, TD, Boffetta, P, Boutron-Ruault, MC, Bracci, PM, Brinton, L, Brooks-Wilson, AR, Bueno-De-Mesquita, HB, Burdett, L, Buring, J, Butler, MA, Cai, Q, Cancel-Tassin, G, Canzian, F, Carrato, A, Carreon, T, Carta, A, Chan, JKC, Chang, ET, Chang, GC, Chang, IS, Chang, J, Chang-Claude, J, Chen, CJ, Chen, CY, Chen, C, Chen, CH, Chen, C, Chen, H, Chen, K, Chen, KY, Chen, KC, Chen, Y, Chen, YH, Chen, YS, Chen, YM, Chien, LH, Chirlaque, MD, Choi, JE, Choi, YY, Chow, WH, Chung, CC, Clavel, J, Clavel-Chapelon, F, Cocco, P, Colt, JS, Comperat, E, Conde, L, Connors, JM, Conti, D, Cortessis, VK, Cotterchio, M, Cozen, W, Crouch, S, Crous-Bou, M, Cussenot, O, Davis, FG, Ding, T, Diver, WR, Dorronsoro, M, Dossus, L, Duell, EJ, Ennas, MG, Erickson, RL, Feychting, M, Flanagan, AM, Foretova, L, Fraumeni, JF, Freedman, ND, Freeman, LEB, Fuchs, C, Gago-Dominguez, M, Gallinger, S, Gao, YT, Gapstur, SM, Garcia-Closas, M, García-Closas, R, Gascoyne, RD, Gastier-Foster, J, Gaudet, MM, Gaziano, JM, Giffen, C, Giles, GG, Giovannucci, E, Glimelius, B, Goggins, M, Gokgoz, N, Goldstein, AM, Gorlick, R, Gross, M, Grubb, R, Gu, J, Guan, P, Gunter, M, Guo, H, Habermann, TM, Haiman, CA, Halai, D, Hallmans, G, Hassan, M, Hattinger, C, He, Q, He, X, Helzlsouer, K, Henderson, B, Henriksson, R, Hjalgrim, H, Hoffman-Bolton, J, Hohensee, C, Holford, TR, Holly, EA, Hong, YC, Hoover, RN, Horn-Ross, PL, Hosain, GMM, Hosgood, HD, Hsiao, CF, Hu, N, Hu, W, Hu, Z, Huang, MS, Huerta, JM, Hung, JY, Hutchinson, A, Inskip, PD, Jackson, RD, Jacobs, EJ, Jenab, M, Jeon, HS, Ji, BT, Jin, G, Jin, L, Johansen, C, Johnson, A, Jung, YJ, Kaaks, R, Kamineni, A, Kane, E, Kang, CH, Karagas, MR, Kelly, RS, Khaw, KT, Kim, C, Kim, HN, Kim, JH, Kim, JS, Kim, YH, Kim, YT, Kim, YC, Kitahara, CM, Klein, AP, Klein, RJ, Kogevinas, M, Kohno, T, Kolonel, LN, Kooperberg, C, Kricker, A, Krogh, V, Kunitoh, H, Kurtz, RC, Kweon, SS, La Croix, A, Lawrence, C, Lecanda, F, Lee, VHF, Li, D, Li, H, Li, J, Li, YJ, Li, Y, Liao, LM, Liebow, M, Lightfoot, T, Lim, WY, Lin, CC, Lin, D, Lindstrom, S, Linet, MS, Link, BK, Liu, C, Liu, J, Liu, L, Ljungberg, B, Lloreta, J, Di Lollo, S, Lu, D, Lund, E, Malats, N, Mannisto, S, Marchand, LL, Marina, N, Masala, G, Mastrangelo, G, Matsuo, K, Maynadie, M, McKay, J, McKean-Cowdin, R, Melbye, M, Melin, BS, Michaud, DS, Mitsudomi, T, Monnereau, A, Montalvan, R, Moore, LE, Mortensen, LM, Nieters, A, North, KE, Novak, AJ, Oberg, AL, Offit, K, Oh, IJ, Olson, SH, Palli, D, Pao, W, Park, IK, Park, JY, Park, KH, Patiño-Garcia, A, Pavanello, S, Peeters, PHM, Perng, RP, Peters, U, Petersen, GM, Picci, P, Pike, MC, Porru, S, Prescott, J, Prokunina-Olsson, L, Qian, B, Qiao, YL, Rais, M, Riboli, E, Riby, J, Risch, HA, Rizzato, C, Rodabough, R, Roman, E, Roupret, M, Ruder, AM, De Sanjose, S, Scelo, G, Schned, A, Schumacher, F, Schwartz, K, Schwenn, M, Scotlandi, K, Seow, A, Serra, C, Serra, M, Sesso, HD, Setiawan, VW, Severi, G, Severson, RK, Shanafelt, TD, Shen, H, Shen, W, Shin, MH, Shiraishi, K, Shu, XO, Siddiq, A, Sierrasesúmaga, L, Sihoe, ADL, Skibola, CF, Smith, A, Smith, MT, Southey, MC, Spinelli, JJ, Staines, A, Stampfer, M, Stern, MC, Stevens, VL, Stolzenberg-Solomon, RS, Su, J, Su, WC, Sund, M, Sung, JS, Sung, SW, Tan, W, Tang, W, Tardón, A, Thomas, D, Thompson, CA, Tinker, LF, Tirabosco, R, Tjønneland, A, Travis, RC, Trichopoulos, D, Tsai, FY, Tsai, YH, Tucker, M, Turner, J, Vajdic, CM, Vermeulen, RCH, Villano, DJ, Vineis, P, Virtamo, J, Visvanathan, K, Wactawski-Wende, J, Wang, C, Wang, CL, Wang, JC, Wang, J, Wei, F, Weiderpass, E, Weiner, GJ, Weinstein, S, Wentzensen, N, White, E, Witzig, TE, Wolpin, BM, Wong, MP, Wu, C, Wu, G, Wu, J, Wu, T, Wu, W, Wu, X, Wu, YL, Wunder, JS, Xiang, YB, Xu, J, Xu, P, Yang, PC, Yang, TY, Ye, Y, Yin, Z, Yokota, J, Yoon, HI, Yu, CJ, Yu, H, Yu, K, Yuan, JM, Zelenetz, A, Zeleniuch-Jacquotte, A, Zhang, XC, Zhang, Y, Zhao, X, Zhao, Z, Zheng, H, Zheng, T, Zheng, W, Zhou, B, Zhu, M, Zucca, M, Boca, SM, Cerhan, JR, Ferri, GM, Hartge, P, Hsiung, CA, Magnani, C, Miligi, L, Morton, LM, Smedby, KE, Teras, LR, Vijai, J, Wang, SS, Brennan, P, Caporaso, NE, Hunter, DJ, Kraft, P, Rothman, N, Silverman, DT, Slager, SL, Chanock, SJ & Chatterjee, N 2016, 'Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types', Journal of the National Cancer Institute, vol. 107, no. 12, djv279. https://doi.org/10.1093/jnci/djv279
Sampson, Joshua N. ; Wheeler, William A. ; Yeager, Meredith ; Panagiotou, Orestis ; Wang, Zhaoming ; Berndt, Sonja I. ; Lan, Qing ; Abnet, Christian C. ; Amundadottir, Laufey T. ; Figueroa, Jonine D. ; Landi, Maria Teresa ; Mirabello, Lisa ; Savage, Sharon A. ; Taylor, Philip R. ; De Vivo, Immaculata ; McGlynn, Katherine A. ; Purdue, Mark P. ; Rajaraman, Preetha ; Adami, Hans Olov ; Ahlbom, Anders ; Albanes, Demetrius ; Amary, Maria Fernanda ; An, She Juan ; Andersson, Ulrika ; Andriole, Gerald ; Andrulis, Irene L. ; Angelucci, Emanuele ; Ansell, Stephen Maxted ; Arici, Cecilia ; Armstrong, Bruce K. ; Arslan, Alan A. ; Austin, Melissa A. ; Baris, Dalsu ; Barkauskas, Donald A. ; Bassig, Bryan A. ; Becker, Nikolaus ; Benavente, Yolanda ; Benhamou, Simone ; Berg, Christine ; Van Den Berg, David ; Bernstein, Leslie ; Bertrand, Kimberly A. ; Birmann, Brenda M. ; Black, Amanda ; Shanafelt, Tait D. ; Boffetta, Paolo ; Boutron-Ruault, Marie Christine ; Bracci, Paige M. ; Brinton, Louise ; Brooks-Wilson, Angela R. ; Bueno-De-Mesquita, H. Bas ; Burdett, Laurie ; Buring, Julie ; Butler, Mary Ann ; Cai, Qiuyin ; Cancel-Tassin, Geraldine ; Canzian, Federico ; Carrato, Alfredo ; Carreon, Tania ; Carta, Angela ; Chan, John K C ; Chang, Ellen T. ; Chang, Gee Chen ; Chang, I. Shou ; Chang, Jiang ; Chang-Claude, Jenny ; Chen, Chien Jen ; Chen, Chih Yi ; Chen, Chu ; Chen, Chung Hsing ; Chen, Constance ; Chen, Hongyan ; Chen, Kexin ; Chen, Kuan Yu ; Chen, Kun Chieh ; Chen, Ying ; Chen, Ying Hsiang ; Chen, Yi Song ; Chen, Yuh Min ; Chien, Li Hsin ; Chirlaque, María Dolores ; Choi, Jin Eun ; Choi, Yi Young ; Chow, Wong Ho ; Chung, Charles C. ; Clavel, Jacqueline ; Clavel-Chapelon, Françoise ; Cocco, Pierluigi ; Colt, Joanne S. ; Comperat, Eva ; Conde, Lucia ; Connors, Joseph M. ; Conti, David ; Cortessis, Victoria K. ; Cotterchio, Michelle ; Cozen, Wendy ; Crouch, Simon ; Crous-Bou, Marta ; Cussenot, Olivier ; Davis, Faith G. ; Ding, Ti ; Diver, W. Ryan ; Dorronsoro, Miren ; Dossus, Laure ; Duell, Eric J. ; Ennas, Maria Grazia ; Erickson, Ralph L. ; Feychting, Maria ; Flanagan, Adrienne M. ; Foretova, Lenka ; Fraumeni, Joseph F. ; Freedman, Neal D. ; Freeman, Laura E Beane ; Fuchs, Charles ; Gago-Dominguez, Manuela ; Gallinger, Steven ; Gao, Yu Tang ; Gapstur, Susan M. ; Garcia-Closas, Montserrat ; García-Closas, Reina ; Gascoyne, Randy D. ; Gastier-Foster, Julie ; Gaudet, Mia M. ; Gaziano, J. Michael ; Giffen, Carol ; Giles, Graham G. ; Giovannucci, Edward ; Glimelius, Bengt ; Goggins, Michael ; Gokgoz, Nalan ; Goldstein, Alisa M. ; Gorlick, Richard ; Gross, Myron ; Grubb, Robert ; Gu, Jian ; Guan, Peng ; Gunter, Marc ; Guo, Huan ; Habermann, Thomas Matthew ; Haiman, Christopher A. ; Halai, Dina ; Hallmans, Goran ; Hassan, Manal ; Hattinger, Claudia ; He, Qincheng ; He, Xingzhou ; Helzlsouer, Kathy ; Henderson, Brian ; Henriksson, Roger ; Hjalgrim, Henrik ; Hoffman-Bolton, Judith ; Hohensee, Chancellor ; Holford, Theodore R. ; Holly, Elizabeth A. ; Hong, Yun Chul ; Hoover, Robert N. ; Horn-Ross, Pamela L. ; Hosain, G. M Monawar ; Hosgood, H. Dean ; Hsiao, Chin Fu ; Hu, Nan ; Hu, Wei ; Hu, Zhibin ; Huang, Ming Shyan ; Huerta, Jose Maria ; Hung, Jen Yu ; Hutchinson, Amy ; Inskip, Peter D. ; Jackson, Rebecca D. ; Jacobs, Eric J. ; Jenab, Mazda ; Jeon, Hyo Sung ; Ji, Bu Tian ; Jin, Guangfu ; Jin, Li ; Johansen, Christoffer ; Johnson, Alison ; Jung, Yoo Jin ; Kaaks, Rudolph ; Kamineni, Aruna ; Kane, Eleanor ; Kang, Chang Hyun ; Karagas, Margaret R. ; Kelly, Rachel S. ; Khaw, Kay Tee ; Kim, Christopher ; Kim, Hee Nam ; Kim, Jin Hee ; Kim, Jun Suk ; Kim, Yeul Hong ; Kim, Young Tae ; Kim, Young Chul ; Kitahara, Cari M. ; Klein, Alison P. ; Klein, Robert J. ; Kogevinas, Manolis ; Kohno, Takashi ; Kolonel, Laurence N. ; Kooperberg, Charles ; Kricker, Anne ; Krogh, Vittorio ; Kunitoh, Hideo ; Kurtz, Robert C. ; Kweon, Sun Seog ; La Croix, Andrea ; Lawrence, Charles ; Lecanda, Fernando ; Lee, Victor Ho Fun ; Li, Donghui ; Li, Haixin ; Li, Jihua ; Li, Yao Jen ; Li, Yuqing ; Liao, Linda M. ; Liebow, Mark ; Lightfoot, Tracy ; Lim, Wei Yen ; Lin, Chien Chung ; Lin, Dongxin ; Lindstrom, Sara ; Linet, Martha S. ; Link, Brian K. ; Liu, Chenwei ; Liu, Jianjun ; Liu, Li ; Ljungberg, Börje ; Lloreta, Josep ; Di Lollo, Simonetta ; Lu, Daru ; Lund, Eiluv ; Malats, Nuria ; Mannisto, Satu ; Marchand, Loic Le ; Marina, Neyssa ; Masala, Giovanna ; Mastrangelo, Giuseppe ; Matsuo, Keitaro ; Maynadie, Marc ; McKay, James ; McKean-Cowdin, Roberta ; Melbye, Mads ; Melin, Beatrice S. ; Michaud, Dominique S. ; Mitsudomi, Tetsuya ; Monnereau, Alain ; Montalvan, Rebecca ; Moore, Lee E. ; Mortensen, Lotte Maxild ; Nieters, Alexandra ; North, Kari E. ; Novak, Anne J ; Oberg, Ann L ; Offit, Kenneth ; Oh, In Jae ; Olson, Sara H. ; Palli, Domenico ; Pao, William ; Park, In Kyu ; Park, Jae Yong ; Park, Kyong Hwa ; Patiño-Garcia, Ana ; Pavanello, Sofia ; Peeters, Petra H M ; Perng, Reury Perng ; Peters, Ulrike ; Petersen, Gloria M ; Picci, Piero ; Pike, Malcolm C. ; Porru, Stefano ; Prescott, Jennifer ; Prokunina-Olsson, Ludmila ; Qian, Biyun ; Qiao, You Lin ; Rais, Marco ; Riboli, Elio ; Riby, Jacques ; Risch, Harvey A. ; Rizzato, Cosmeri ; Rodabough, Rebecca ; Roman, Eve ; Roupret, Morgan ; Ruder, Avima M. ; De Sanjose, Silvia ; Scelo, Ghislaine ; Schned, Alan ; Schumacher, Fredrick ; Schwartz, Kendra ; Schwenn, Molly ; Scotlandi, Katia ; Seow, Adeline ; Serra, Consol ; Serra, Massimo ; Sesso, Howard D. ; Setiawan, Veronica Wendy ; Severi, Gianluca ; Severson, Richard K. ; Shanafelt, Tait D. ; Shen, Hongbing ; Shen, Wei ; Shin, Min Ho ; Shiraishi, Kouya ; Shu, Xiao Ou ; Siddiq, Afshan ; Sierrasesúmaga, Luis ; Sihoe, Alan Dart Loon ; Skibola, Christine F. ; Smith, Alex ; Smith, Martyn T. ; Southey, Melissa C. ; Spinelli, John J. ; Staines, Anthony ; Stampfer, Meir ; Stern, Marianna C. ; Stevens, Victoria L. ; Stolzenberg-Solomon, Rachael S. ; Su, Jian ; Su, Wu Chou ; Sund, Malin ; Sung, Jae Sook ; Sung, Sook Whan ; Tan, Wen ; Tang, Wei ; Tardón, Adonina ; Thomas, David ; Thompson, Carrie A ; Tinker, Lesley F. ; Tirabosco, Roberto ; Tjønneland, Anne ; Travis, Ruth C. ; Trichopoulos, Dimitrios ; Tsai, Fang Yu ; Tsai, Ying Huang ; Tucker, Margaret ; Turner, Jenny ; Vajdic, Claire M. ; Vermeulen, Roel C H ; Villano, Danylo J. ; Vineis, Paolo ; Virtamo, Jarmo ; Visvanathan, Kala ; Wactawski-Wende, Jean ; Wang, Chaoyu ; Wang, Chih Liang ; Wang, Jiu Cun ; Wang, Junwen ; Wei, Fusheng ; Weiderpass, Elisabete ; Weiner, George J. ; Weinstein, Stephanie ; Wentzensen, Nicolas ; White, Emily ; Witzig, Thomas Elmer ; Wolpin, Brian M. ; Wong, Maria Pik ; Wu, Chen ; Wu, Guoping ; Wu, Junjie ; Wu, Tangchun ; Wu, Wei ; Wu, Xifeng ; Wu, Yi Long ; Wunder, Jay S. ; Xiang, Yong Bing ; Xu, Jun ; Xu, Ping ; Yang, Pan Chyr ; Yang, Tsung Ying ; Ye, Yuanqing ; Yin, Zhihua ; Yokota, Jun ; Yoon, Ho Il ; Yu, Chong Jen ; Yu, Herbert ; Yu, Kai ; Yuan, Jian Min ; Zelenetz, Andrew ; Zeleniuch-Jacquotte, Anne ; Zhang, Xu Chao ; Zhang, Yawei ; Zhao, Xueying ; Zhao, Zhenhong ; Zheng, Hong ; Zheng, Tongzhang ; Zheng, Wei ; Zhou, Baosen ; Zhu, Meng ; Zucca, Mariagrazia ; Boca, Simina M. ; Cerhan, James R ; Ferri, Giovanni M. ; Hartge, Patricia ; Hsiung, Chao Agnes ; Magnani, Corrado ; Miligi, Lucia ; Morton, Lindsay M. ; Smedby, Karin E. ; Teras, Lauren R. ; Vijai, Joseph ; Wang, Sophia S. ; Brennan, Paul ; Caporaso, Neil E. ; Hunter, David J. ; Kraft, Peter ; Rothman, Nathaniel ; Silverman, Debra T. ; Slager, Susan L ; Chanock, Stephen J. ; Chatterjee, Nilanjan. / Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. In: Journal of the National Cancer Institute. 2016 ; Vol. 107, No. 12.
@article{acfb809b7111458893aad9c4f4665221,
title = "Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types",
abstract = "Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl 2, on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24{\%} (95{\%} confidence interval [CI] = 14{\%} to 37{\%}) and 7{\%} (95{\%} CI = 4{\%} to 11{\%}) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.",
author = "Sampson, {Joshua N.} and Wheeler, {William A.} and Meredith Yeager and Orestis Panagiotou and Zhaoming Wang and Berndt, {Sonja I.} and Qing Lan and Abnet, {Christian C.} and Amundadottir, {Laufey T.} and Figueroa, {Jonine D.} and Landi, {Maria Teresa} and Lisa Mirabello and Savage, {Sharon A.} and Taylor, {Philip R.} and {De Vivo}, Immaculata and McGlynn, {Katherine A.} and Purdue, {Mark P.} and Preetha Rajaraman and Adami, {Hans Olov} and Anders Ahlbom and Demetrius Albanes and Amary, {Maria Fernanda} and An, {She Juan} and Ulrika Andersson and Gerald Andriole and Andrulis, {Irene L.} and Emanuele Angelucci and Ansell, {Stephen Maxted} and Cecilia Arici and Armstrong, {Bruce K.} and Arslan, {Alan A.} and Austin, {Melissa A.} and Dalsu Baris and Barkauskas, {Donald A.} and Bassig, {Bryan A.} and Nikolaus Becker and Yolanda Benavente and Simone Benhamou and Christine Berg and {Van Den Berg}, David and Leslie Bernstein and Bertrand, {Kimberly A.} and Birmann, {Brenda M.} and Amanda Black and Shanafelt, {Tait D.} and Paolo Boffetta and Boutron-Ruault, {Marie Christine} and Bracci, {Paige M.} and Louise Brinton and Brooks-Wilson, {Angela R.} and Bueno-De-Mesquita, {H. Bas} and Laurie Burdett and Julie Buring and Butler, {Mary Ann} and Qiuyin Cai and Geraldine Cancel-Tassin and Federico Canzian and Alfredo Carrato and Tania Carreon and Angela Carta and Chan, {John K C} and Chang, {Ellen T.} and Chang, {Gee Chen} and Chang, {I. Shou} and Jiang Chang and Jenny Chang-Claude and Chen, {Chien Jen} and Chen, {Chih Yi} and Chu Chen and Chen, {Chung Hsing} and Constance Chen and Hongyan Chen and Kexin Chen and Chen, {Kuan Yu} and Chen, {Kun Chieh} and Ying Chen and Chen, {Ying Hsiang} and Chen, {Yi Song} and Chen, {Yuh Min} and Chien, {Li Hsin} and Chirlaque, {Mar{\'i}a Dolores} and Choi, {Jin Eun} and Choi, {Yi Young} and Chow, {Wong Ho} and Chung, {Charles C.} and Jacqueline Clavel and Fran{\cc}oise Clavel-Chapelon and Pierluigi Cocco and Colt, {Joanne S.} and Eva Comperat and Lucia Conde and Connors, {Joseph M.} and David Conti and Cortessis, {Victoria K.} and Michelle Cotterchio and Wendy Cozen and Simon Crouch and Marta Crous-Bou and Olivier Cussenot and Davis, {Faith G.} and Ti Ding and Diver, {W. Ryan} and Miren Dorronsoro and Laure Dossus and Duell, {Eric J.} and Ennas, {Maria Grazia} and Erickson, {Ralph L.} and Maria Feychting and Flanagan, {Adrienne M.} and Lenka Foretova and Fraumeni, {Joseph F.} and Freedman, {Neal D.} and Freeman, {Laura E Beane} and Charles Fuchs and Manuela Gago-Dominguez and Steven Gallinger and Gao, {Yu Tang} and Gapstur, {Susan M.} and Montserrat Garcia-Closas and Reina Garc{\'i}a-Closas and Gascoyne, {Randy D.} and Julie Gastier-Foster and Gaudet, {Mia M.} and Gaziano, {J. Michael} and Carol Giffen and Giles, {Graham G.} and Edward Giovannucci and Bengt Glimelius and Michael Goggins and Nalan Gokgoz and Goldstein, {Alisa M.} and Richard Gorlick and Myron Gross and Robert Grubb and Jian Gu and Peng Guan and Marc Gunter and Huan Guo and Habermann, {Thomas Matthew} and Haiman, {Christopher A.} and Dina Halai and Goran Hallmans and Manal Hassan and Claudia Hattinger and Qincheng He and Xingzhou He and Kathy Helzlsouer and Brian Henderson and Roger Henriksson and Henrik Hjalgrim and Judith Hoffman-Bolton and Chancellor Hohensee and Holford, {Theodore R.} and Holly, {Elizabeth A.} and Hong, {Yun Chul} and Hoover, {Robert N.} and Horn-Ross, {Pamela L.} and Hosain, {G. M Monawar} and Hosgood, {H. Dean} and Hsiao, {Chin Fu} and Nan Hu and Wei Hu and Zhibin Hu and Huang, {Ming Shyan} and Huerta, {Jose Maria} and Hung, {Jen Yu} and Amy Hutchinson and Inskip, {Peter D.} and Jackson, {Rebecca D.} and Jacobs, {Eric J.} and Mazda Jenab and Jeon, {Hyo Sung} and Ji, {Bu Tian} and Guangfu Jin and Li Jin and Christoffer Johansen and Alison Johnson and Jung, {Yoo Jin} and Rudolph Kaaks and Aruna Kamineni and Eleanor Kane and Kang, {Chang Hyun} and Karagas, {Margaret R.} and Kelly, {Rachel S.} and Khaw, {Kay Tee} and Christopher Kim and Kim, {Hee Nam} and Kim, {Jin Hee} and Kim, {Jun Suk} and Kim, {Yeul Hong} and Kim, {Young Tae} and Kim, {Young Chul} and Kitahara, {Cari M.} and Klein, {Alison P.} and Klein, {Robert J.} and Manolis Kogevinas and Takashi Kohno and Kolonel, {Laurence N.} and Charles Kooperberg and Anne Kricker and Vittorio Krogh and Hideo Kunitoh and Kurtz, {Robert C.} and Kweon, {Sun Seog} and {La Croix}, Andrea and Charles Lawrence and Fernando Lecanda and Lee, {Victor Ho Fun} and Donghui Li and Haixin Li and Jihua Li and Li, {Yao Jen} and Yuqing Li and Liao, {Linda M.} and Mark Liebow and Tracy Lightfoot and Lim, {Wei Yen} and Lin, {Chien Chung} and Dongxin Lin and Sara Lindstrom and Linet, {Martha S.} and Link, {Brian K.} and Chenwei Liu and Jianjun Liu and Li Liu and B{\"o}rje Ljungberg and Josep Lloreta and {Di Lollo}, Simonetta and Daru Lu and Eiluv Lund and Nuria Malats and Satu Mannisto and Marchand, {Loic Le} and Neyssa Marina and Giovanna Masala and Giuseppe Mastrangelo and Keitaro Matsuo and Marc Maynadie and James McKay and Roberta McKean-Cowdin and Mads Melbye and Melin, {Beatrice S.} and Michaud, {Dominique S.} and Tetsuya Mitsudomi and Alain Monnereau and Rebecca Montalvan and Moore, {Lee E.} and Mortensen, {Lotte Maxild} and Alexandra Nieters and North, {Kari E.} and Novak, {Anne J} and Oberg, {Ann L} and Kenneth Offit and Oh, {In Jae} and Olson, {Sara H.} and Domenico Palli and William Pao and Park, {In Kyu} and Park, {Jae Yong} and Park, {Kyong Hwa} and Ana Pati{\~n}o-Garcia and Sofia Pavanello and Peeters, {Petra H M} and Perng, {Reury Perng} and Ulrike Peters and Petersen, {Gloria M} and Piero Picci and Pike, {Malcolm C.} and Stefano Porru and Jennifer Prescott and Ludmila Prokunina-Olsson and Biyun Qian and Qiao, {You Lin} and Marco Rais and Elio Riboli and Jacques Riby and Risch, {Harvey A.} and Cosmeri Rizzato and Rebecca Rodabough and Eve Roman and Morgan Roupret and Ruder, {Avima M.} and {De Sanjose}, Silvia and Ghislaine Scelo and Alan Schned and Fredrick Schumacher and Kendra Schwartz and Molly Schwenn and Katia Scotlandi and Adeline Seow and Consol Serra and Massimo Serra and Sesso, {Howard D.} and Setiawan, {Veronica Wendy} and Gianluca Severi and Severson, {Richard K.} and Shanafelt, {Tait D.} and Hongbing Shen and Wei Shen and Shin, {Min Ho} and Kouya Shiraishi and Shu, {Xiao Ou} and Afshan Siddiq and Luis Sierrases{\'u}maga and Sihoe, {Alan Dart Loon} and Skibola, {Christine F.} and Alex Smith and Smith, {Martyn T.} and Southey, {Melissa C.} and Spinelli, {John J.} and Anthony Staines and Meir Stampfer and Stern, {Marianna C.} and Stevens, {Victoria L.} and Stolzenberg-Solomon, {Rachael S.} and Jian Su and Su, {Wu Chou} and Malin Sund and Sung, {Jae Sook} and Sung, {Sook Whan} and Wen Tan and Wei Tang and Adonina Tard{\'o}n and David Thomas and Thompson, {Carrie A} and Tinker, {Lesley F.} and Roberto Tirabosco and Anne Tj{\o}nneland and Travis, {Ruth C.} and Dimitrios Trichopoulos and Tsai, {Fang Yu} and Tsai, {Ying Huang} and Margaret Tucker and Jenny Turner and Vajdic, {Claire M.} and Vermeulen, {Roel C H} and Villano, {Danylo J.} and Paolo Vineis and Jarmo Virtamo and Kala Visvanathan and Jean Wactawski-Wende and Chaoyu Wang and Wang, {Chih Liang} and Wang, {Jiu Cun} and Junwen Wang and Fusheng Wei and Elisabete Weiderpass and Weiner, {George J.} and Stephanie Weinstein and Nicolas Wentzensen and Emily White and Witzig, {Thomas Elmer} and Wolpin, {Brian M.} and Wong, {Maria Pik} and Chen Wu and Guoping Wu and Junjie Wu and Tangchun Wu and Wei Wu and Xifeng Wu and Wu, {Yi Long} and Wunder, {Jay S.} and Xiang, {Yong Bing} and Jun Xu and Ping Xu and Yang, {Pan Chyr} and Yang, {Tsung Ying} and Yuanqing Ye and Zhihua Yin and Jun Yokota and Yoon, {Ho Il} and Yu, {Chong Jen} and Herbert Yu and Kai Yu and Yuan, {Jian Min} and Andrew Zelenetz and Anne Zeleniuch-Jacquotte and Zhang, {Xu Chao} and Yawei Zhang and Xueying Zhao and Zhenhong Zhao and Hong Zheng and Tongzhang Zheng and Wei Zheng and Baosen Zhou and Meng Zhu and Mariagrazia Zucca and Boca, {Simina M.} and Cerhan, {James R} and Ferri, {Giovanni M.} and Patricia Hartge and Hsiung, {Chao Agnes} and Corrado Magnani and Lucia Miligi and Morton, {Lindsay M.} and Smedby, {Karin E.} and Teras, {Lauren R.} and Joseph Vijai and Wang, {Sophia S.} and Paul Brennan and Caporaso, {Neil E.} and Hunter, {David J.} and Peter Kraft and Nathaniel Rothman and Silverman, {Debra T.} and Slager, {Susan L} and Chanock, {Stephen J.} and Nilanjan Chatterjee",
year = "2016",
doi = "10.1093/jnci/djv279",
language = "English (US)",
volume = "107",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

AU - Sampson, Joshua N.

AU - Wheeler, William A.

AU - Yeager, Meredith

AU - Panagiotou, Orestis

AU - Wang, Zhaoming

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AU - Lan, Qing

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AU - Amundadottir, Laufey T.

AU - Figueroa, Jonine D.

AU - Landi, Maria Teresa

AU - Mirabello, Lisa

AU - Savage, Sharon A.

AU - Taylor, Philip R.

AU - De Vivo, Immaculata

AU - McGlynn, Katherine A.

AU - Purdue, Mark P.

AU - Rajaraman, Preetha

AU - Adami, Hans Olov

AU - Ahlbom, Anders

AU - Albanes, Demetrius

AU - Amary, Maria Fernanda

AU - An, She Juan

AU - Andersson, Ulrika

AU - Andriole, Gerald

AU - Andrulis, Irene L.

AU - Angelucci, Emanuele

AU - Ansell, Stephen Maxted

AU - Arici, Cecilia

AU - Armstrong, Bruce K.

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AU - Austin, Melissa A.

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AU - Barkauskas, Donald A.

AU - Bassig, Bryan A.

AU - Becker, Nikolaus

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AU - Berg, Christine

AU - Van Den Berg, David

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AU - Bertrand, Kimberly A.

AU - Birmann, Brenda M.

AU - Black, Amanda

AU - Shanafelt, Tait D.

AU - Boffetta, Paolo

AU - Boutron-Ruault, Marie Christine

AU - Bracci, Paige M.

AU - Brinton, Louise

AU - Brooks-Wilson, Angela R.

AU - Bueno-De-Mesquita, H. Bas

AU - Burdett, Laurie

AU - Buring, Julie

AU - Butler, Mary Ann

AU - Cai, Qiuyin

AU - Cancel-Tassin, Geraldine

AU - Canzian, Federico

AU - Carrato, Alfredo

AU - Carreon, Tania

AU - Carta, Angela

AU - Chan, John K C

AU - Chang, Ellen T.

AU - Chang, Gee Chen

AU - Chang, I. Shou

AU - Chang, Jiang

AU - Chang-Claude, Jenny

AU - Chen, Chien Jen

AU - Chen, Chih Yi

AU - Chen, Chu

AU - Chen, Chung Hsing

AU - Chen, Constance

AU - Chen, Hongyan

AU - Chen, Kexin

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AU - Chen, Kun Chieh

AU - Chen, Ying

AU - Chen, Ying Hsiang

AU - Chen, Yi Song

AU - Chen, Yuh Min

AU - Chien, Li Hsin

AU - Chirlaque, María Dolores

AU - Choi, Jin Eun

AU - Choi, Yi Young

AU - Chow, Wong Ho

AU - Chung, Charles C.

AU - Clavel, Jacqueline

AU - Clavel-Chapelon, Françoise

AU - Cocco, Pierluigi

AU - Colt, Joanne S.

AU - Comperat, Eva

AU - Conde, Lucia

AU - Connors, Joseph M.

AU - Conti, David

AU - Cortessis, Victoria K.

AU - Cotterchio, Michelle

AU - Cozen, Wendy

AU - Crouch, Simon

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AU - Cussenot, Olivier

AU - Davis, Faith G.

AU - Ding, Ti

AU - Diver, W. Ryan

AU - Dorronsoro, Miren

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AU - Ennas, Maria Grazia

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AU - Feychting, Maria

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AU - Foretova, Lenka

AU - Fraumeni, Joseph F.

AU - Freedman, Neal D.

AU - Freeman, Laura E Beane

AU - Fuchs, Charles

AU - Gago-Dominguez, Manuela

AU - Gallinger, Steven

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AU - Garcia-Closas, Montserrat

AU - García-Closas, Reina

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AU - Gaziano, J. Michael

AU - Giffen, Carol

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AU - Glimelius, Bengt

AU - Goggins, Michael

AU - Gokgoz, Nalan

AU - Goldstein, Alisa M.

AU - Gorlick, Richard

AU - Gross, Myron

AU - Grubb, Robert

AU - Gu, Jian

AU - Guan, Peng

AU - Gunter, Marc

AU - Guo, Huan

AU - Habermann, Thomas Matthew

AU - Haiman, Christopher A.

AU - Halai, Dina

AU - Hallmans, Goran

AU - Hassan, Manal

AU - Hattinger, Claudia

AU - He, Qincheng

AU - He, Xingzhou

AU - Helzlsouer, Kathy

AU - Henderson, Brian

AU - Henriksson, Roger

AU - Hjalgrim, Henrik

AU - Hoffman-Bolton, Judith

AU - Hohensee, Chancellor

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Hong, Yun Chul

AU - Hoover, Robert N.

AU - Horn-Ross, Pamela L.

AU - Hosain, G. M Monawar

AU - Hosgood, H. Dean

AU - Hsiao, Chin Fu

AU - Hu, Nan

AU - Hu, Wei

AU - Hu, Zhibin

AU - Huang, Ming Shyan

AU - Huerta, Jose Maria

AU - Hung, Jen Yu

AU - Hutchinson, Amy

AU - Inskip, Peter D.

AU - Jackson, Rebecca D.

AU - Jacobs, Eric J.

AU - Jenab, Mazda

AU - Jeon, Hyo Sung

AU - Ji, Bu Tian

AU - Jin, Guangfu

AU - Jin, Li

AU - Johansen, Christoffer

AU - Johnson, Alison

AU - Jung, Yoo Jin

AU - Kaaks, Rudolph

AU - Kamineni, Aruna

AU - Kane, Eleanor

AU - Kang, Chang Hyun

AU - Karagas, Margaret R.

AU - Kelly, Rachel S.

AU - Khaw, Kay Tee

AU - Kim, Christopher

AU - Kim, Hee Nam

AU - Kim, Jin Hee

AU - Kim, Jun Suk

AU - Kim, Yeul Hong

AU - Kim, Young Tae

AU - Kim, Young Chul

AU - Kitahara, Cari M.

AU - Klein, Alison P.

AU - Klein, Robert J.

AU - Kogevinas, Manolis

AU - Kohno, Takashi

AU - Kolonel, Laurence N.

AU - Kooperberg, Charles

AU - Kricker, Anne

AU - Krogh, Vittorio

AU - Kunitoh, Hideo

AU - Kurtz, Robert C.

AU - Kweon, Sun Seog

AU - La Croix, Andrea

AU - Lawrence, Charles

AU - Lecanda, Fernando

AU - Lee, Victor Ho Fun

AU - Li, Donghui

AU - Li, Haixin

AU - Li, Jihua

AU - Li, Yao Jen

AU - Li, Yuqing

AU - Liao, Linda M.

AU - Liebow, Mark

AU - Lightfoot, Tracy

AU - Lim, Wei Yen

AU - Lin, Chien Chung

AU - Lin, Dongxin

AU - Lindstrom, Sara

AU - Linet, Martha S.

AU - Link, Brian K.

AU - Liu, Chenwei

AU - Liu, Jianjun

AU - Liu, Li

AU - Ljungberg, Börje

AU - Lloreta, Josep

AU - Di Lollo, Simonetta

AU - Lu, Daru

AU - Lund, Eiluv

AU - Malats, Nuria

AU - Mannisto, Satu

AU - Marchand, Loic Le

AU - Marina, Neyssa

AU - Masala, Giovanna

AU - Mastrangelo, Giuseppe

AU - Matsuo, Keitaro

AU - Maynadie, Marc

AU - McKay, James

AU - McKean-Cowdin, Roberta

AU - Melbye, Mads

AU - Melin, Beatrice S.

AU - Michaud, Dominique S.

AU - Mitsudomi, Tetsuya

AU - Monnereau, Alain

AU - Montalvan, Rebecca

AU - Moore, Lee E.

AU - Mortensen, Lotte Maxild

AU - Nieters, Alexandra

AU - North, Kari E.

AU - Novak, Anne J

AU - Oberg, Ann L

AU - Offit, Kenneth

AU - Oh, In Jae

AU - Olson, Sara H.

AU - Palli, Domenico

AU - Pao, William

AU - Park, In Kyu

AU - Park, Jae Yong

AU - Park, Kyong Hwa

AU - Patiño-Garcia, Ana

AU - Pavanello, Sofia

AU - Peeters, Petra H M

AU - Perng, Reury Perng

AU - Peters, Ulrike

AU - Petersen, Gloria M

AU - Picci, Piero

AU - Pike, Malcolm C.

AU - Porru, Stefano

AU - Prescott, Jennifer

AU - Prokunina-Olsson, Ludmila

AU - Qian, Biyun

AU - Qiao, You Lin

AU - Rais, Marco

AU - Riboli, Elio

AU - Riby, Jacques

AU - Risch, Harvey A.

AU - Rizzato, Cosmeri

AU - Rodabough, Rebecca

AU - Roman, Eve

AU - Roupret, Morgan

AU - Ruder, Avima M.

AU - De Sanjose, Silvia

AU - Scelo, Ghislaine

AU - Schned, Alan

AU - Schumacher, Fredrick

AU - Schwartz, Kendra

AU - Schwenn, Molly

AU - Scotlandi, Katia

AU - Seow, Adeline

AU - Serra, Consol

AU - Serra, Massimo

AU - Sesso, Howard D.

AU - Setiawan, Veronica Wendy

AU - Severi, Gianluca

AU - Severson, Richard K.

AU - Shanafelt, Tait D.

AU - Shen, Hongbing

AU - Shen, Wei

AU - Shin, Min Ho

AU - Shiraishi, Kouya

AU - Shu, Xiao Ou

AU - Siddiq, Afshan

AU - Sierrasesúmaga, Luis

AU - Sihoe, Alan Dart Loon

AU - Skibola, Christine F.

AU - Smith, Alex

AU - Smith, Martyn T.

AU - Southey, Melissa C.

AU - Spinelli, John J.

AU - Staines, Anthony

AU - Stampfer, Meir

AU - Stern, Marianna C.

AU - Stevens, Victoria L.

AU - Stolzenberg-Solomon, Rachael S.

AU - Su, Jian

AU - Su, Wu Chou

AU - Sund, Malin

AU - Sung, Jae Sook

AU - Sung, Sook Whan

AU - Tan, Wen

AU - Tang, Wei

AU - Tardón, Adonina

AU - Thomas, David

AU - Thompson, Carrie A

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AU - Tirabosco, Roberto

AU - Tjønneland, Anne

AU - Travis, Ruth C.

AU - Trichopoulos, Dimitrios

AU - Tsai, Fang Yu

AU - Tsai, Ying Huang

AU - Tucker, Margaret

AU - Turner, Jenny

AU - Vajdic, Claire M.

AU - Vermeulen, Roel C H

AU - Villano, Danylo J.

AU - Vineis, Paolo

AU - Virtamo, Jarmo

AU - Visvanathan, Kala

AU - Wactawski-Wende, Jean

AU - Wang, Chaoyu

AU - Wang, Chih Liang

AU - Wang, Jiu Cun

AU - Wang, Junwen

AU - Wei, Fusheng

AU - Weiderpass, Elisabete

AU - Weiner, George J.

AU - Weinstein, Stephanie

AU - Wentzensen, Nicolas

AU - White, Emily

AU - Witzig, Thomas Elmer

AU - Wolpin, Brian M.

AU - Wong, Maria Pik

AU - Wu, Chen

AU - Wu, Guoping

AU - Wu, Junjie

AU - Wu, Tangchun

AU - Wu, Wei

AU - Wu, Xifeng

AU - Wu, Yi Long

AU - Wunder, Jay S.

AU - Xiang, Yong Bing

AU - Xu, Jun

AU - Xu, Ping

AU - Yang, Pan Chyr

AU - Yang, Tsung Ying

AU - Ye, Yuanqing

AU - Yin, Zhihua

AU - Yokota, Jun

AU - Yoon, Ho Il

AU - Yu, Chong Jen

AU - Yu, Herbert

AU - Yu, Kai

AU - Yuan, Jian Min

AU - Zelenetz, Andrew

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Xu Chao

AU - Zhang, Yawei

AU - Zhao, Xueying

AU - Zhao, Zhenhong

AU - Zheng, Hong

AU - Zheng, Tongzhang

AU - Zheng, Wei

AU - Zhou, Baosen

AU - Zhu, Meng

AU - Zucca, Mariagrazia

AU - Boca, Simina M.

AU - Cerhan, James R

AU - Ferri, Giovanni M.

AU - Hartge, Patricia

AU - Hsiung, Chao Agnes

AU - Magnani, Corrado

AU - Miligi, Lucia

AU - Morton, Lindsay M.

AU - Smedby, Karin E.

AU - Teras, Lauren R.

AU - Vijai, Joseph

AU - Wang, Sophia S.

AU - Brennan, Paul

AU - Caporaso, Neil E.

AU - Hunter, David J.

AU - Kraft, Peter

AU - Rothman, Nathaniel

AU - Silverman, Debra T.

AU - Slager, Susan L

AU - Chanock, Stephen J.

AU - Chatterjee, Nilanjan

PY - 2016

Y1 - 2016

N2 - Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl 2, on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

AB - Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl 2, on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

UR - http://www.scopus.com/inward/record.url?scp=84981719326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981719326&partnerID=8YFLogxK

U2 - 10.1093/jnci/djv279

DO - 10.1093/jnci/djv279

M3 - Article

C2 - 26464424

AN - SCOPUS:84981719326

VL - 107

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 12

M1 - djv279

ER -