Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma

Steven J. Buskirk, Leonard L. Gunderson, Steven E. Schild, Claire E. Bender, Hugh J. Williams, Donald C. McIlrath, Jay S. Robinow, William J. Tremaine, J. Kirk Martin

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Abstract

Thirty-four patients with subtotally resected or unresectable carcinoma of the extrahepatic bile ducts received radiation therapy; a minimum of 45 Gy (external beam) to the tumor and regional lymph nodes ±5-fluorouracil (5-FU). Seventeen patients received an external beam boost of 5 to 15 Gy to the tumor, and a specialized boost was used in the remaining 17 patients (iridium-192 transcatheter seeds in 10 and intraoperative radiation therapy (IORT) with electrons in seven). The median time to death in all 34 patients was 12 months (range, 4 to 98 months). The only patients who survived longer than 18 months were those either with gross total or subtotal resection before external irradiation (2 of 6) or who received specialized boosts (192Ir, 3 of 10; IORT, 3 of 7). Local failure was documented in 9 of 17 patients who received external beam irradiation alone ±5-FU, 3 of 10 patients who received an 192Ir boost, and 2 of 6 patients who received an IORT boost with curative intent.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalAnnals of Surgery
Volume215
Issue number2
StatePublished - 1992

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Extrahepatic Bile Ducts
Carcinoma
Radiotherapy
Fluorouracil
Iridium
Neoplasms
Seeds
Lymph Nodes
Electrons

ASJC Scopus subject areas

  • Surgery

Cite this

Buskirk, S. J., Gunderson, L. L., Schild, S. E., Bender, C. E., Williams, H. J., McIlrath, D. C., ... Kirk Martin, J. (1992). Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. Annals of Surgery, 215(2), 125-131.

Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. / Buskirk, Steven J.; Gunderson, Leonard L.; Schild, Steven E.; Bender, Claire E.; Williams, Hugh J.; McIlrath, Donald C.; Robinow, Jay S.; Tremaine, William J.; Kirk Martin, J.

In: Annals of Surgery, Vol. 215, No. 2, 1992, p. 125-131.

Research output: Contribution to journalArticle

Buskirk, SJ, Gunderson, LL, Schild, SE, Bender, CE, Williams, HJ, McIlrath, DC, Robinow, JS, Tremaine, WJ & Kirk Martin, J 1992, 'Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma', Annals of Surgery, vol. 215, no. 2, pp. 125-131.
Buskirk SJ, Gunderson LL, Schild SE, Bender CE, Williams HJ, McIlrath DC et al. Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. Annals of Surgery. 1992;215(2):125-131.
Buskirk, Steven J. ; Gunderson, Leonard L. ; Schild, Steven E. ; Bender, Claire E. ; Williams, Hugh J. ; McIlrath, Donald C. ; Robinow, Jay S. ; Tremaine, William J. ; Kirk Martin, J. / Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. In: Annals of Surgery. 1992 ; Vol. 215, No. 2. pp. 125-131.
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AU - Kirk Martin, J.

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