Analysis of factors that predict alcohol relapse following liver transplantation

Sameer Jauhar, Jayant A. Talwalkar, Terry Schneekloth, Sheila Jowsey, Russell H. Wiesner, K. V Narayanan Menon

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Alcoholic liver disease has become a major indication for liver transplantation in the United States. Factors that predict alcohol relapse after liver transplantation are poorly defined. The aim of our study was to identify predictors of alcohol relapse in patients undergoing liver transplantation for alcoholic liver disease. One hundred and eleven patients undergoing liver transplantation for alcoholic liver disease between 1985 and 1999 were identified from our database. Patients were selected for liver transplantation if their risk of relapse was felt to be low by the transplant team. A chart review was conducted to determine if relapse had occurred, the presence or absence of factors that were thought to predict relapse, and survival. Demographic and psychosocial variables were analyzed using univariate and multivariate logistic regression to identify independent predictors of relapse. The median duration of abstinence before liver transplantation was 15 months (range: 1-120). Hepatitis C virus was present in 64% of patients. A family history of alcoholism in a first-degree relative was identified in 38%, and 78% received treatment for alcoholism before liver transplantation. The mean duration of follow-up was 44.1 ± 3.7 months. There were 29 deaths (26%) overall. Seventeen patients (15%) returned to alcohol use. On multivariate analysis a family history of alcoholism was found to be an independent predictor of alcohol relapse (P= .03). Further prospective studies are needed to examine this association in greater detail to provide targeted treatment for alcoholism both before and after liver transplantation.

Original languageEnglish (US)
Pages (from-to)408-411
Number of pages4
JournalLiver Transplantation
Volume10
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Liver Transplantation
Statistical Factor Analysis
Alcohols
Recurrence
Alcoholic Liver Diseases
Alcoholism
Hepacivirus
Multivariate Analysis
Logistic Models
Demography
Databases
Prospective Studies
Transplants
Survival
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Jauhar, S., Talwalkar, J. A., Schneekloth, T., Jowsey, S., Wiesner, R. H., & Menon, K. V. N. (2004). Analysis of factors that predict alcohol relapse following liver transplantation. Liver Transplantation, 10(3), 408-411. https://doi.org/10.1002/lt.20086

Analysis of factors that predict alcohol relapse following liver transplantation. / Jauhar, Sameer; Talwalkar, Jayant A.; Schneekloth, Terry; Jowsey, Sheila; Wiesner, Russell H.; Menon, K. V Narayanan.

In: Liver Transplantation, Vol. 10, No. 3, 03.2004, p. 408-411.

Research output: Contribution to journalArticle

Jauhar, S, Talwalkar, JA, Schneekloth, T, Jowsey, S, Wiesner, RH & Menon, KVN 2004, 'Analysis of factors that predict alcohol relapse following liver transplantation', Liver Transplantation, vol. 10, no. 3, pp. 408-411. https://doi.org/10.1002/lt.20086
Jauhar S, Talwalkar JA, Schneekloth T, Jowsey S, Wiesner RH, Menon KVN. Analysis of factors that predict alcohol relapse following liver transplantation. Liver Transplantation. 2004 Mar;10(3):408-411. https://doi.org/10.1002/lt.20086
Jauhar, Sameer ; Talwalkar, Jayant A. ; Schneekloth, Terry ; Jowsey, Sheila ; Wiesner, Russell H. ; Menon, K. V Narayanan. / Analysis of factors that predict alcohol relapse following liver transplantation. In: Liver Transplantation. 2004 ; Vol. 10, No. 3. pp. 408-411.
@article{719f2d3e2bc8491c81187d375e419ded,
title = "Analysis of factors that predict alcohol relapse following liver transplantation",
abstract = "Alcoholic liver disease has become a major indication for liver transplantation in the United States. Factors that predict alcohol relapse after liver transplantation are poorly defined. The aim of our study was to identify predictors of alcohol relapse in patients undergoing liver transplantation for alcoholic liver disease. One hundred and eleven patients undergoing liver transplantation for alcoholic liver disease between 1985 and 1999 were identified from our database. Patients were selected for liver transplantation if their risk of relapse was felt to be low by the transplant team. A chart review was conducted to determine if relapse had occurred, the presence or absence of factors that were thought to predict relapse, and survival. Demographic and psychosocial variables were analyzed using univariate and multivariate logistic regression to identify independent predictors of relapse. The median duration of abstinence before liver transplantation was 15 months (range: 1-120). Hepatitis C virus was present in 64{\%} of patients. A family history of alcoholism in a first-degree relative was identified in 38{\%}, and 78{\%} received treatment for alcoholism before liver transplantation. The mean duration of follow-up was 44.1 ± 3.7 months. There were 29 deaths (26{\%}) overall. Seventeen patients (15{\%}) returned to alcohol use. On multivariate analysis a family history of alcoholism was found to be an independent predictor of alcohol relapse (P= .03). Further prospective studies are needed to examine this association in greater detail to provide targeted treatment for alcoholism both before and after liver transplantation.",
author = "Sameer Jauhar and Talwalkar, {Jayant A.} and Terry Schneekloth and Sheila Jowsey and Wiesner, {Russell H.} and Menon, {K. V Narayanan}",
year = "2004",
month = "3",
doi = "10.1002/lt.20086",
language = "English (US)",
volume = "10",
pages = "408--411",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Analysis of factors that predict alcohol relapse following liver transplantation

AU - Jauhar, Sameer

AU - Talwalkar, Jayant A.

AU - Schneekloth, Terry

AU - Jowsey, Sheila

AU - Wiesner, Russell H.

AU - Menon, K. V Narayanan

PY - 2004/3

Y1 - 2004/3

N2 - Alcoholic liver disease has become a major indication for liver transplantation in the United States. Factors that predict alcohol relapse after liver transplantation are poorly defined. The aim of our study was to identify predictors of alcohol relapse in patients undergoing liver transplantation for alcoholic liver disease. One hundred and eleven patients undergoing liver transplantation for alcoholic liver disease between 1985 and 1999 were identified from our database. Patients were selected for liver transplantation if their risk of relapse was felt to be low by the transplant team. A chart review was conducted to determine if relapse had occurred, the presence or absence of factors that were thought to predict relapse, and survival. Demographic and psychosocial variables were analyzed using univariate and multivariate logistic regression to identify independent predictors of relapse. The median duration of abstinence before liver transplantation was 15 months (range: 1-120). Hepatitis C virus was present in 64% of patients. A family history of alcoholism in a first-degree relative was identified in 38%, and 78% received treatment for alcoholism before liver transplantation. The mean duration of follow-up was 44.1 ± 3.7 months. There were 29 deaths (26%) overall. Seventeen patients (15%) returned to alcohol use. On multivariate analysis a family history of alcoholism was found to be an independent predictor of alcohol relapse (P= .03). Further prospective studies are needed to examine this association in greater detail to provide targeted treatment for alcoholism both before and after liver transplantation.

AB - Alcoholic liver disease has become a major indication for liver transplantation in the United States. Factors that predict alcohol relapse after liver transplantation are poorly defined. The aim of our study was to identify predictors of alcohol relapse in patients undergoing liver transplantation for alcoholic liver disease. One hundred and eleven patients undergoing liver transplantation for alcoholic liver disease between 1985 and 1999 were identified from our database. Patients were selected for liver transplantation if their risk of relapse was felt to be low by the transplant team. A chart review was conducted to determine if relapse had occurred, the presence or absence of factors that were thought to predict relapse, and survival. Demographic and psychosocial variables were analyzed using univariate and multivariate logistic regression to identify independent predictors of relapse. The median duration of abstinence before liver transplantation was 15 months (range: 1-120). Hepatitis C virus was present in 64% of patients. A family history of alcoholism in a first-degree relative was identified in 38%, and 78% received treatment for alcoholism before liver transplantation. The mean duration of follow-up was 44.1 ± 3.7 months. There were 29 deaths (26%) overall. Seventeen patients (15%) returned to alcohol use. On multivariate analysis a family history of alcoholism was found to be an independent predictor of alcohol relapse (P= .03). Further prospective studies are needed to examine this association in greater detail to provide targeted treatment for alcoholism both before and after liver transplantation.

UR - http://www.scopus.com/inward/record.url?scp=1642316250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642316250&partnerID=8YFLogxK

U2 - 10.1002/lt.20086

DO - 10.1002/lt.20086

M3 - Article

C2 - 15004769

AN - SCOPUS:1642316250

VL - 10

SP - 408

EP - 411

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 3

ER -