TY - GEN
T1 - Analysis of epileptogenic network properties during ictal activity
AU - Wilke, Christopher
AU - Worrell, Gregory A.
AU - He, Bin
PY - 2009
Y1 - 2009
N2 - In the present study, we utilize methods from graph theory to analyze epileptogenic network properties during periods of ictal activity. Using these methods, we analyzed the DTF-based causal information flow in nine seizures recorded from two patients undergoing presurgical monitoring for the treatment of medically intractable epilepsy. From the results, we observed a high degree of correlation between the regions with a high amount of information outflow (termed the outdegree) and the cortical areas identified clinically as the generators of the ictal activity. We furthermore observe a frequency-dependent correlation between the co-localization of these "activated regions" and the clinical foci. These findings suggest that application of network analysis tools to ictal activity could provide clinically useful information concerning these epileptogenic networks.
AB - In the present study, we utilize methods from graph theory to analyze epileptogenic network properties during periods of ictal activity. Using these methods, we analyzed the DTF-based causal information flow in nine seizures recorded from two patients undergoing presurgical monitoring for the treatment of medically intractable epilepsy. From the results, we observed a high degree of correlation between the regions with a high amount of information outflow (termed the outdegree) and the cortical areas identified clinically as the generators of the ictal activity. We furthermore observe a frequency-dependent correlation between the co-localization of these "activated regions" and the clinical foci. These findings suggest that application of network analysis tools to ictal activity could provide clinically useful information concerning these epileptogenic networks.
UR - http://www.scopus.com/inward/record.url?scp=77950997946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950997946&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5334866
DO - 10.1109/IEMBS.2009.5334866
M3 - Conference contribution
C2 - 19964953
AN - SCOPUS:77950997946
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 2220
EP - 2223
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -