Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer

Mark Gibbs, Lisa Chakrabarti, Janet L. Stanford, Ellen L Goode, Suzanne Kolb, Eugene F. Schuster, Valerie A. Buckley, Morgan Shook, Leroy Hood, Gail P. Jarvik, Elaine A. Ostrander

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P = .1). If heterogeneity is assumed, an estimated 4%-9% of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.

Original languageEnglish (US)
Pages (from-to)1087-1095
Number of pages9
JournalAmerican Journal of Human Genetics
Volume64
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Chromosomes
Pedigree
Genetic Recombination
protein C activator peptide

ASJC Scopus subject areas

  • Genetics

Cite this

Gibbs, M., Chakrabarti, L., Stanford, J. L., Goode, E. L., Kolb, S., Schuster, E. F., ... Ostrander, E. A. (1999). Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer. American Journal of Human Genetics, 64(4), 1087-1095. https://doi.org/10.1086/302342

Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer. / Gibbs, Mark; Chakrabarti, Lisa; Stanford, Janet L.; Goode, Ellen L; Kolb, Suzanne; Schuster, Eugene F.; Buckley, Valerie A.; Shook, Morgan; Hood, Leroy; Jarvik, Gail P.; Ostrander, Elaine A.

In: American Journal of Human Genetics, Vol. 64, No. 4, 1999, p. 1087-1095.

Research output: Contribution to journalArticle

Gibbs, M, Chakrabarti, L, Stanford, JL, Goode, EL, Kolb, S, Schuster, EF, Buckley, VA, Shook, M, Hood, L, Jarvik, GP & Ostrander, EA 1999, 'Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer', American Journal of Human Genetics, vol. 64, no. 4, pp. 1087-1095. https://doi.org/10.1086/302342
Gibbs, Mark ; Chakrabarti, Lisa ; Stanford, Janet L. ; Goode, Ellen L ; Kolb, Suzanne ; Schuster, Eugene F. ; Buckley, Valerie A. ; Shook, Morgan ; Hood, Leroy ; Jarvik, Gail P. ; Ostrander, Elaine A. / Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer. In: American Journal of Human Genetics. 1999 ; Vol. 64, No. 4. pp. 1087-1095.
@article{7cdeaf00aeb746ba82c3c6f5f197b57e,
title = "Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer",
abstract = "One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P = .1). If heterogeneity is assumed, an estimated 4{\%}-9{\%} of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.",
author = "Mark Gibbs and Lisa Chakrabarti and Stanford, {Janet L.} and Goode, {Ellen L} and Suzanne Kolb and Schuster, {Eugene F.} and Buckley, {Valerie A.} and Morgan Shook and Leroy Hood and Jarvik, {Gail P.} and Ostrander, {Elaine A.}",
year = "1999",
doi = "10.1086/302342",
language = "English (US)",
volume = "64",
pages = "1087--1095",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Analysis of chromosome 1q42.2-43 in 152 Families with high risk of prostate cancer

AU - Gibbs, Mark

AU - Chakrabarti, Lisa

AU - Stanford, Janet L.

AU - Goode, Ellen L

AU - Kolb, Suzanne

AU - Schuster, Eugene F.

AU - Buckley, Valerie A.

AU - Shook, Morgan

AU - Hood, Leroy

AU - Jarvik, Gail P.

AU - Ostrander, Elaine A.

PY - 1999

Y1 - 1999

N2 - One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P = .1). If heterogeneity is assumed, an estimated 4%-9% of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.

AB - One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P = .1). If heterogeneity is assumed, an estimated 4%-9% of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.

UR - http://www.scopus.com/inward/record.url?scp=0033358086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033358086&partnerID=8YFLogxK

U2 - 10.1086/302342

DO - 10.1086/302342

M3 - Article

VL - 64

SP - 1087

EP - 1095

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 4

ER -