Analysis of carbon-based microelectrodes for neurochemical sensing

Felicia S. Manciu, Yoonbae Oh, Abhijeet Barath, Aaron E. Rusheen, Abbas Z. Kouzani, Deidra Hodges, Jose Guerrero, Jonathan Tomshine, Kendall H. Lee, Kevin E. Bennet

Research output: Contribution to journalArticle

Abstract

The comprehensive microscopic, spectroscopic, and in vitro voltammetric analysis presented in this work, which builds on the well-studied properties of carbon-based materials, facilitates potential ways for improvement of carbon fiber microelectrodes (CFMs) for neuroscience applications. Investigations by both, scanning electron microscopy (SEM) and confocal Raman spectroscopy, confirm a higher degree of structural ordering for the fibers exposed to carbonization temperatures. An evident correlation is also identified between the extent of structural defects observed from SEM and Raman results with the CFM electrochemical performance for dopamine detection. To improve CFM physico-chemical surface stability and increase its mechanical resistance to the induced compressive stress during anticipated in vivo tissue penetration, successful coating of the carbon fiber with boron-doped diamond (BDD) is also performed and microspectroscopically analyzed here. The absence of spectral shifts of the diamond Raman vibrational signature verifies that the growth of an unstrained BDD thin film was achieved. Although more work needs to be done to identify optimal parameter values for improved BDD deposition, this study serves as a demonstration of foundational technology for the development of more sensitive electrochemical sensors, that may have been impractical previously for clinical applications, due to limitations in either safety or performance.

Original languageEnglish (US)
Article number3186
JournalMaterials
Volume12
Issue number19
DOIs
StatePublished - Oct 1 2019

Fingerprint

Microelectrodes
Diamond
Carbon fibers
Boron
Carbon
Diamonds
Electrochemical sensors
Scanning electron microscopy
Diamond films
Carbonization
Compressive stress
Raman spectroscopy
Dopamine
Demonstrations
Tissue
Thin films
Coatings
Defects
carbon fiber
Fibers

Keywords

  • Boron-doped diamond thin film
  • Carbon fiber
  • Confocal Raman spectroscopy
  • Fast-scan cyclic voltammetry (FSCV)
  • Scanning electron microscopy (SEM)

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Manciu, F. S., Oh, Y., Barath, A., Rusheen, A. E., Kouzani, A. Z., Hodges, D., ... Bennet, K. E. (2019). Analysis of carbon-based microelectrodes for neurochemical sensing. Materials, 12(19), [3186]. https://doi.org/10.3390/ma12193186

Analysis of carbon-based microelectrodes for neurochemical sensing. / Manciu, Felicia S.; Oh, Yoonbae; Barath, Abhijeet; Rusheen, Aaron E.; Kouzani, Abbas Z.; Hodges, Deidra; Guerrero, Jose; Tomshine, Jonathan; Lee, Kendall H.; Bennet, Kevin E.

In: Materials, Vol. 12, No. 19, 3186, 01.10.2019.

Research output: Contribution to journalArticle

Manciu, FS, Oh, Y, Barath, A, Rusheen, AE, Kouzani, AZ, Hodges, D, Guerrero, J, Tomshine, J, Lee, KH & Bennet, KE 2019, 'Analysis of carbon-based microelectrodes for neurochemical sensing', Materials, vol. 12, no. 19, 3186. https://doi.org/10.3390/ma12193186
Manciu FS, Oh Y, Barath A, Rusheen AE, Kouzani AZ, Hodges D et al. Analysis of carbon-based microelectrodes for neurochemical sensing. Materials. 2019 Oct 1;12(19). 3186. https://doi.org/10.3390/ma12193186
Manciu, Felicia S. ; Oh, Yoonbae ; Barath, Abhijeet ; Rusheen, Aaron E. ; Kouzani, Abbas Z. ; Hodges, Deidra ; Guerrero, Jose ; Tomshine, Jonathan ; Lee, Kendall H. ; Bennet, Kevin E. / Analysis of carbon-based microelectrodes for neurochemical sensing. In: Materials. 2019 ; Vol. 12, No. 19.
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