Analysis of benign ventricular tumors: Long-term outcome after resection

Andrew W. ElBardissi, Joseph A. Dearani, Richard C. Daly, Charles J. Mullany, Thomas A. Orszulak, Francisco J. Puga, Hartzell V Schaff

Research output: Contribution to journalArticle

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Abstract

Objective: We sought to compare clinical and pathologic characteristics of ventricular tumors and to detect whether differences exist in short- and long-term survival after resection. Methods: From 1964 to 2005, 323 patients had cardiac surgery for resection of primary cardiac tumors; 53 (16%) patients had primary ventricular tumors. We randomly sampled 53 characteristics of ventricular tumors. Results: Patients with ventricular tumors were younger than those with atrial tumors (34.8 vs 54.6 years; P < .0001). New York Heart Association functional status was similar at presentation, although patients with atrial tumors had increased risk of atrial fibrillation (P < .05), thromboembolic events (P = .04), and mitral stenosis (P = .008) at the time of presentation. Patients with ventricular tumors had an increased incidence of myocardial invasion (14% vs 2%; P = .02) and had significantly longer cardiopulmonary bypass (80 vs 65 minutes; P < .05) and crossclamp (52 vs 39 minutes; P = .03) times. Operative mortality was 4% and 0% in the ventricular and atrial groups, respectively (P = not significant). Follow-up was obtained in 89% of patients at a mean follow-up time of 7.21 years. A Kaplan-Meier survival plot demonstrated no difference in survival characteristics of both groups. At follow-up, 81% and 74% of ventricular and atrial tumors, respectively, were minimally symptomatic (New York Heart Association class I/II; P = .13). Patients with atrial and ventricular tumors had a 6% and 0% tumor recurrence rate, respectively (P = .12). Conclusion: Surgical resection for ventricular tumors is effective and results in excellent long-term outcome. Early surgical treatment should be strongly considered in patients with primary ventricular tumors.

Original languageEnglish (US)
Pages (from-to)1061-1068
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume135
Issue number5
DOIs
StatePublished - May 2008

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Neoplasms
Survival
Heart Neoplasms
Mitral Valve Stenosis
Cardiopulmonary Bypass
Atrial Fibrillation
Thoracic Surgery
Recurrence
Mortality
Incidence
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

ElBardissi, A. W., Dearani, J. A., Daly, R. C., Mullany, C. J., Orszulak, T. A., Puga, F. J., & Schaff, H. V. (2008). Analysis of benign ventricular tumors: Long-term outcome after resection. Journal of Thoracic and Cardiovascular Surgery, 135(5), 1061-1068. https://doi.org/10.1016/j.jtcvs.2007.10.048

Analysis of benign ventricular tumors : Long-term outcome after resection. / ElBardissi, Andrew W.; Dearani, Joseph A.; Daly, Richard C.; Mullany, Charles J.; Orszulak, Thomas A.; Puga, Francisco J.; Schaff, Hartzell V.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 135, No. 5, 05.2008, p. 1061-1068.

Research output: Contribution to journalArticle

ElBardissi, AW, Dearani, JA, Daly, RC, Mullany, CJ, Orszulak, TA, Puga, FJ & Schaff, HV 2008, 'Analysis of benign ventricular tumors: Long-term outcome after resection', Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 5, pp. 1061-1068. https://doi.org/10.1016/j.jtcvs.2007.10.048
ElBardissi, Andrew W. ; Dearani, Joseph A. ; Daly, Richard C. ; Mullany, Charles J. ; Orszulak, Thomas A. ; Puga, Francisco J. ; Schaff, Hartzell V. / Analysis of benign ventricular tumors : Long-term outcome after resection. In: Journal of Thoracic and Cardiovascular Surgery. 2008 ; Vol. 135, No. 5. pp. 1061-1068.
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abstract = "Objective: We sought to compare clinical and pathologic characteristics of ventricular tumors and to detect whether differences exist in short- and long-term survival after resection. Methods: From 1964 to 2005, 323 patients had cardiac surgery for resection of primary cardiac tumors; 53 (16{\%}) patients had primary ventricular tumors. We randomly sampled 53 characteristics of ventricular tumors. Results: Patients with ventricular tumors were younger than those with atrial tumors (34.8 vs 54.6 years; P < .0001). New York Heart Association functional status was similar at presentation, although patients with atrial tumors had increased risk of atrial fibrillation (P < .05), thromboembolic events (P = .04), and mitral stenosis (P = .008) at the time of presentation. Patients with ventricular tumors had an increased incidence of myocardial invasion (14{\%} vs 2{\%}; P = .02) and had significantly longer cardiopulmonary bypass (80 vs 65 minutes; P < .05) and crossclamp (52 vs 39 minutes; P = .03) times. Operative mortality was 4{\%} and 0{\%} in the ventricular and atrial groups, respectively (P = not significant). Follow-up was obtained in 89{\%} of patients at a mean follow-up time of 7.21 years. A Kaplan-Meier survival plot demonstrated no difference in survival characteristics of both groups. At follow-up, 81{\%} and 74{\%} of ventricular and atrial tumors, respectively, were minimally symptomatic (New York Heart Association class I/II; P = .13). Patients with atrial and ventricular tumors had a 6{\%} and 0{\%} tumor recurrence rate, respectively (P = .12). Conclusion: Surgical resection for ventricular tumors is effective and results in excellent long-term outcome. Early surgical treatment should be strongly considered in patients with primary ventricular tumors.",
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AB - Objective: We sought to compare clinical and pathologic characteristics of ventricular tumors and to detect whether differences exist in short- and long-term survival after resection. Methods: From 1964 to 2005, 323 patients had cardiac surgery for resection of primary cardiac tumors; 53 (16%) patients had primary ventricular tumors. We randomly sampled 53 characteristics of ventricular tumors. Results: Patients with ventricular tumors were younger than those with atrial tumors (34.8 vs 54.6 years; P < .0001). New York Heart Association functional status was similar at presentation, although patients with atrial tumors had increased risk of atrial fibrillation (P < .05), thromboembolic events (P = .04), and mitral stenosis (P = .008) at the time of presentation. Patients with ventricular tumors had an increased incidence of myocardial invasion (14% vs 2%; P = .02) and had significantly longer cardiopulmonary bypass (80 vs 65 minutes; P < .05) and crossclamp (52 vs 39 minutes; P = .03) times. Operative mortality was 4% and 0% in the ventricular and atrial groups, respectively (P = not significant). Follow-up was obtained in 89% of patients at a mean follow-up time of 7.21 years. A Kaplan-Meier survival plot demonstrated no difference in survival characteristics of both groups. At follow-up, 81% and 74% of ventricular and atrial tumors, respectively, were minimally symptomatic (New York Heart Association class I/II; P = .13). Patients with atrial and ventricular tumors had a 6% and 0% tumor recurrence rate, respectively (P = .12). Conclusion: Surgical resection for ventricular tumors is effective and results in excellent long-term outcome. Early surgical treatment should be strongly considered in patients with primary ventricular tumors.

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