Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

M. C. O'Donovan; Nadine Norton; H. Williams; T. Peirce; V. Moskvina; I. Nikolov; M. Hamshere; L. Carroll; L. Georgieva; S. Dwyer; P. Holmans; J. L. Marchini; C. C A Spencer; B. Howie; H. T. Leung; I. Giegling; A. M. Hartmann; H. J. Möller; D. W. Morris; Y. Shi; G. Feng; P. Hoffmann; P. Propping; C. Vasilescu; W. Maier; M. Rietschel; S. Zammit; J. Schumacher; E. M. Quinn; T. G. Schulze; N. Iwata; M. Ikeda; A. Darvasi; S. Shifman; L. He; J. Duan; A. R. Sanders; D. F. Levinson; R. Adolfsson; U. Ösby; L. Terenius; E. G. Jönsson; S. Cichon; M. M. Nöthen; M. Gill; A. P. Corvin; D. Rujescu; P. V. Gejman; G. Kirov; N. Craddock; N. M. Williams; M. J. Owen; P. V. Gejman; A. R. Sanders; J. Duan; D. F. Levinson; N. G. Buccola; B. J. Mowry; R. Freedman; F. Amin; D. W. Black; J. M. Silverman; W. J. Byerley; C. R. Cloninger

doi:10.1038/mp.2008.108

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

M. C. O'Donovan, Nadine Norton, H. Williams, T. Peirce, V. Moskvina, I. Nikolov, M. Hamshere, L. Carroll, L. Georgieva, S. Dwyer, P. Holmans, J. L. Marchini, C. C A Spencer, B. Howie, H. T. Leung, I. Giegling, A. M. Hartmann, H. J. Möller, D. W. Morris, Y. ShiG. Feng, P. Hoffmann, P. Propping, C. Vasilescu, W. Maier, M. Rietschel, S. Zammit, J. Schumacher, E. M. Quinn, T. G. Schulze, N. Iwata, M. Ikeda, A. Darvasi, S. Shifman, L. He, J. Duan, A. R. Sanders, D. F. Levinson, R. Adolfsson, U. Ösby, L. Terenius, E. G. Jönsson, S. Cichon, M. M. Nöthen, M. Gill, A. P. Corvin, D. Rujescu, P. V. Gejman, G. Kirov, N. Craddock, N. M. Williams, M. J. Owen, P. V. Gejman, A. R. Sanders, J. Duan, D. F. Levinson, N. G. Buccola, B. J. Mowry, R. Freedman, F. Amin, D. W. Black, J. M. Silverman, W. J. Byerley, C. R. Cloninger

Research output: Contribution to journal › Article

52 Citations (Scopus)

Abstract

We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the United States/Australia, Germany, China, Japan, Israel and Sweden (n=5142 cases/6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.

Original language	English (US)
Pages (from-to)	30-36
Number of pages	7
Journal	Molecular Psychiatry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/mp.2008.108
State	Published - Jan 25 2009
Externally published	Yes

Fingerprint

Receptor, Fibroblast Growth Factor, Type 2

Single Nucleotide Polymorphism

Schizophrenia

Genome-Wide Association Study

Germany

Nucleotide Mapping

Genes

Bulgaria

Israel

Ireland

Sweden

Meta-Analysis

China

Japan

Chromosomes

Alleles

Keywords

FGFR2
Genome-wide association study
Schizophrenia

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

Cite this

O'Donovan, M. C., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., ... Cloninger, C. R. (2009). Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry, 14(1), 30-36. https://doi.org/10.1038/mp.2008.108

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. / O'Donovan, M. C.; Norton, Nadine; Williams, H.; Peirce, T.; Moskvina, V.; Nikolov, I.; Hamshere, M.; Carroll, L.; Georgieva, L.; Dwyer, S.; Holmans, P.; Marchini, J. L.; Spencer, C. C A; Howie, B.; Leung, H. T.; Giegling, I.; Hartmann, A. M.; Möller, H. J.; Morris, D. W.; Shi, Y.; Feng, G.; Hoffmann, P.; Propping, P.; Vasilescu, C.; Maier, W.; Rietschel, M.; Zammit, S.; Schumacher, J.; Quinn, E. M.; Schulze, T. G.; Iwata, N.; Ikeda, M.; Darvasi, A.; Shifman, S.; He, L.; Duan, J.; Sanders, A. R.; Levinson, D. F.; Adolfsson, R.; Ösby, U.; Terenius, L.; Jönsson, E. G.; Cichon, S.; Nöthen, M. M.; Gill, M.; Corvin, A. P.; Rujescu, D.; Gejman, P. V.; Kirov, G.; Craddock, N.; Williams, N. M.; Owen, M. J.; Gejman, P. V.; Sanders, A. R.; Duan, J.; Levinson, D. F.; Buccola, N. G.; Mowry, B. J.; Freedman, R.; Amin, F.; Black, D. W.; Silverman, J. M.; Byerley, W. J.; Cloninger, C. R.

In: Molecular Psychiatry, Vol. 14, No. 1, 25.01.2009, p. 30-36.

Research output: Contribution to journal › Article

O'Donovan, MC, Norton, N, Williams, H, Peirce, T, Moskvina, V, Nikolov, I, Hamshere, M, Carroll, L, Georgieva, L, Dwyer, S, Holmans, P, Marchini, JL, Spencer, CCA, Howie, B, Leung, HT, Giegling, I, Hartmann, AM, Möller, HJ, Morris, DW, Shi, Y, Feng, G, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, EM, Schulze, TG, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, AR, Levinson, DF, Adolfsson, R, Ösby, U, Terenius, L, Jönsson, EG, Cichon, S, Nöthen, MM, Gill, M, Corvin, AP, Rujescu, D, Gejman, PV, Kirov, G, Craddock, N, Williams, NM, Owen, MJ, Gejman, PV, Sanders, AR, Duan, J, Levinson, DF, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WJ & Cloninger, CR 2009, 'Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2', Molecular Psychiatry, vol. 14, no. 1, pp. 30-36. https://doi.org/10.1038/mp.2008.108

O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I et al. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry. 2009 Jan 25;14(1):30-36. https://doi.org/10.1038/mp.2008.108

O'Donovan, M. C. ; Norton, Nadine ; Williams, H. ; Peirce, T. ; Moskvina, V. ; Nikolov, I. ; Hamshere, M. ; Carroll, L. ; Georgieva, L. ; Dwyer, S. ; Holmans, P. ; Marchini, J. L. ; Spencer, C. C A ; Howie, B. ; Leung, H. T. ; Giegling, I. ; Hartmann, A. M. ; Möller, H. J. ; Morris, D. W. ; Shi, Y. ; Feng, G. ; Hoffmann, P. ; Propping, P. ; Vasilescu, C. ; Maier, W. ; Rietschel, M. ; Zammit, S. ; Schumacher, J. ; Quinn, E. M. ; Schulze, T. G. ; Iwata, N. ; Ikeda, M. ; Darvasi, A. ; Shifman, S. ; He, L. ; Duan, J. ; Sanders, A. R. ; Levinson, D. F. ; Adolfsson, R. ; Ösby, U. ; Terenius, L. ; Jönsson, E. G. ; Cichon, S. ; Nöthen, M. M. ; Gill, M. ; Corvin, A. P. ; Rujescu, D. ; Gejman, P. V. ; Kirov, G. ; Craddock, N. ; Williams, N. M. ; Owen, M. J. ; Gejman, P. V. ; Sanders, A. R. ; Duan, J. ; Levinson, D. F. ; Buccola, N. G. ; Mowry, B. J. ; Freedman, R. ; Amin, F. ; Black, D. W. ; Silverman, J. M. ; Byerley, W. J. ; Cloninger, C. R. / Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. In: Molecular Psychiatry. 2009 ; Vol. 14, No. 1. pp. 30-36.

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abstract = "We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the United States/Australia, Germany, China, Japan, Israel and Sweden (n=5142 cases/6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95{\%} CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.",

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AU - Moskvina, V.

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10.1038/mp.2008.108