Analogs of p-bromophenylacetylurea: A structure activity study of their neurotoxicity in rats

William Stephen Brimijoin, G. Carlson, N. N. Nguyen, J. Jakobsen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A total of 9 analogs of p-bromophenylacetylurea were synthesized and tested for their ability to induce limb weakness in the rat, as determined by a double-blind, clinical scoring system. The BPAU itself regularly led to hindlimb paralysis after a latent period of 5 days; however, none of the tested analogs caused perceptible changes in motor function, even when they were administered in large doses. It was concluded that the structural requirements for BPAU neurotoxicity are exceedingly stringent.

Original languageEnglish (US)
JournalMuscle and Nerve
Volume5
Issue number9 Spec.
StatePublished - 1982

Fingerprint

Hindlimb
Paralysis
Extremities
4-bromophenylacetylurea

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Analogs of p-bromophenylacetylurea : A structure activity study of their neurotoxicity in rats. / Brimijoin, William Stephen; Carlson, G.; Nguyen, N. N.; Jakobsen, J.

In: Muscle and Nerve, Vol. 5, No. 9 Spec., 1982.

Research output: Contribution to journalArticle

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