Analogs of p-bromophenylacetylurea: A structure activity study of their neurotoxicity in rats

S. Brimijoin, G. Carlson, N. N. Nguyen, J. Jakobsen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A total of 9 analogs of p-bromophenylacetylurea were synthesized and tested for their ability to induce limb weakness in the rat, as determined by a double-blind, clinical scoring system. The BPAU itself regularly led to hindlimb paralysis after a latent period of 5 days; however, none of the tested analogs caused perceptible changes in motor function, even when they were administered in large doses. It was concluded that the structural requirements for BPAU neurotoxicity are exceedingly stringent.

Original languageEnglish (US)
Pages (from-to)S122-S126
JournalMuscle and Nerve
Volume5
Issue number9 Spec.
StatePublished - 1982

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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