Abstract
A total of 9 analogs of p-bromophenylacetylurea were synthesized and tested for their ability to induce limb weakness in the rat, as determined by a double-blind, clinical scoring system. The BPAU itself regularly led to hindlimb paralysis after a latent period of 5 days; however, none of the tested analogs caused perceptible changes in motor function, even when they were administered in large doses. It was concluded that the structural requirements for BPAU neurotoxicity are exceedingly stringent.
Original language | English (US) |
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Pages (from-to) | S122-S126 |
Journal | Muscle and Nerve |
Volume | 5 |
Issue number | 9 Spec. |
State | Published - 1982 |
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)