Anagrelide: An update on its mechanisms of action and therapeutic potential

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Thrombocytosis is an increasingly recognized clinical problem due to the widespread availability of automated cell counters. While reactive thrombocytosis does not require any therapeutic intervention, clonal thrombocytosis may require therapy to prevent thrombohemorrhagic complications. The clinician has a number of therapeutic options available when confronted with a patient having clonal thrombocytosis. One of these agents is anagrelide (Agrylin®, Bristol-Myers Squibb). In this drug profile, a synopsis of the available data on this agent and its role in the control of thrombocytosis will be provided. The main side effects of the medication are discussed, as well as the potential future developments in the field.

Original languageEnglish (US)
Pages (from-to)533-541
Number of pages9
JournalExpert review of anticancer therapy
Volume4
Issue number4
DOIs
StatePublished - Aug 2004

Keywords

  • Anagrelide
  • Essential thrombocythemia
  • Myeloproliferative disorders
  • Thrombocytosis

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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