An update on the epidemiology of inflammatory bowel disease in Asia

Kelvin T. Thia, Edward Vincent Loftus, Jr, William J. Sandborn, Suk Kyun Yang

Research output: Contribution to journalReview article

352 Citations (Scopus)

Abstract

A rising trend in the incidence and prevalence of inflammatory bowel disease (IBD) in Asia has been recognized for the past two decades. It has been postulated that this phenomenon may be related to the westernization of lifestyles, including changes in dietary habits and environmental changes such as improved sanitation and industrialization. Previously we reported that the incidence and prevalence rates of IBD in Asia were low compared with the West, but there was a notably rising secular trend. In this review, we summarize the recent epidemiological data in Asia, characterize the clinical features, risk factors and genetic susceptibility of Asian IBD patients, and compare these to those of Western IBD patients. In the past decade, the incidence and prevalence of IBD reported across Asia, particularly in East Asia, has continued to increase. Familial clustering is generally uncommon in East Asia but appears to be higher in West Asia. The genetic susceptibilities in Asian IBD patients differ from those of White patients, as NOD2/CARD15 mutations are much less common. The clinical phenotypes and complication rates of Asian IBD resemble the White population in general, but with some differences, including lower surgical rates, higher prevalence of males, and higher prevalence of ileocolonic involvement among East Asian Crohn's disease patients, and a low frequency of primary sclerosing cholangitis among IBD patients in East and Southeast Asia.

Original languageEnglish (US)
Pages (from-to)3167-3182
Number of pages16
JournalAmerican Journal of Gastroenterology
Volume103
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Inflammatory Bowel Diseases
Epidemiology
Far East
Genetic Predisposition to Disease
Incidence
Sclerosing Cholangitis
Southeastern Asia
Sanitation
Feeding Behavior
Crohn Disease
Cluster Analysis
Life Style
Phenotype
Mutation
Population

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

An update on the epidemiology of inflammatory bowel disease in Asia. / Thia, Kelvin T.; Loftus, Jr, Edward Vincent; Sandborn, William J.; Yang, Suk Kyun.

In: American Journal of Gastroenterology, Vol. 103, No. 12, 12.2008, p. 3167-3182.

Research output: Contribution to journalReview article

Thia, Kelvin T. ; Loftus, Jr, Edward Vincent ; Sandborn, William J. ; Yang, Suk Kyun. / An update on the epidemiology of inflammatory bowel disease in Asia. In: American Journal of Gastroenterology. 2008 ; Vol. 103, No. 12. pp. 3167-3182.
@article{843f7283ae704c4b94a32858c426da29,
title = "An update on the epidemiology of inflammatory bowel disease in Asia",
abstract = "A rising trend in the incidence and prevalence of inflammatory bowel disease (IBD) in Asia has been recognized for the past two decades. It has been postulated that this phenomenon may be related to the westernization of lifestyles, including changes in dietary habits and environmental changes such as improved sanitation and industrialization. Previously we reported that the incidence and prevalence rates of IBD in Asia were low compared with the West, but there was a notably rising secular trend. In this review, we summarize the recent epidemiological data in Asia, characterize the clinical features, risk factors and genetic susceptibility of Asian IBD patients, and compare these to those of Western IBD patients. In the past decade, the incidence and prevalence of IBD reported across Asia, particularly in East Asia, has continued to increase. Familial clustering is generally uncommon in East Asia but appears to be higher in West Asia. The genetic susceptibilities in Asian IBD patients differ from those of White patients, as NOD2/CARD15 mutations are much less common. The clinical phenotypes and complication rates of Asian IBD resemble the White population in general, but with some differences, including lower surgical rates, higher prevalence of males, and higher prevalence of ileocolonic involvement among East Asian Crohn's disease patients, and a low frequency of primary sclerosing cholangitis among IBD patients in East and Southeast Asia.",
author = "Thia, {Kelvin T.} and {Loftus, Jr}, {Edward Vincent} and Sandborn, {William J.} and Yang, {Suk Kyun}",
year = "2008",
month = "12",
doi = "10.1111/j.1572-0241.2008.02158.x",
language = "English (US)",
volume = "103",
pages = "3167--3182",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - An update on the epidemiology of inflammatory bowel disease in Asia

AU - Thia, Kelvin T.

AU - Loftus, Jr, Edward Vincent

AU - Sandborn, William J.

AU - Yang, Suk Kyun

PY - 2008/12

Y1 - 2008/12

N2 - A rising trend in the incidence and prevalence of inflammatory bowel disease (IBD) in Asia has been recognized for the past two decades. It has been postulated that this phenomenon may be related to the westernization of lifestyles, including changes in dietary habits and environmental changes such as improved sanitation and industrialization. Previously we reported that the incidence and prevalence rates of IBD in Asia were low compared with the West, but there was a notably rising secular trend. In this review, we summarize the recent epidemiological data in Asia, characterize the clinical features, risk factors and genetic susceptibility of Asian IBD patients, and compare these to those of Western IBD patients. In the past decade, the incidence and prevalence of IBD reported across Asia, particularly in East Asia, has continued to increase. Familial clustering is generally uncommon in East Asia but appears to be higher in West Asia. The genetic susceptibilities in Asian IBD patients differ from those of White patients, as NOD2/CARD15 mutations are much less common. The clinical phenotypes and complication rates of Asian IBD resemble the White population in general, but with some differences, including lower surgical rates, higher prevalence of males, and higher prevalence of ileocolonic involvement among East Asian Crohn's disease patients, and a low frequency of primary sclerosing cholangitis among IBD patients in East and Southeast Asia.

AB - A rising trend in the incidence and prevalence of inflammatory bowel disease (IBD) in Asia has been recognized for the past two decades. It has been postulated that this phenomenon may be related to the westernization of lifestyles, including changes in dietary habits and environmental changes such as improved sanitation and industrialization. Previously we reported that the incidence and prevalence rates of IBD in Asia were low compared with the West, but there was a notably rising secular trend. In this review, we summarize the recent epidemiological data in Asia, characterize the clinical features, risk factors and genetic susceptibility of Asian IBD patients, and compare these to those of Western IBD patients. In the past decade, the incidence and prevalence of IBD reported across Asia, particularly in East Asia, has continued to increase. Familial clustering is generally uncommon in East Asia but appears to be higher in West Asia. The genetic susceptibilities in Asian IBD patients differ from those of White patients, as NOD2/CARD15 mutations are much less common. The clinical phenotypes and complication rates of Asian IBD resemble the White population in general, but with some differences, including lower surgical rates, higher prevalence of males, and higher prevalence of ileocolonic involvement among East Asian Crohn's disease patients, and a low frequency of primary sclerosing cholangitis among IBD patients in East and Southeast Asia.

UR - http://www.scopus.com/inward/record.url?scp=58149390157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149390157&partnerID=8YFLogxK

U2 - 10.1111/j.1572-0241.2008.02158.x

DO - 10.1111/j.1572-0241.2008.02158.x

M3 - Review article

C2 - 19086963

AN - SCOPUS:58149390157

VL - 103

SP - 3167

EP - 3182

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 12

ER -