An Update on Stem Cell Therapies for Acute Coronary Syndrome

Peter J. Psaltis, Daniel B. Spoon, Dennis T L Wong, Rajiv Gulati

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Well into the second decade since its conception, cell transplantation continues to undergo intensive evaluation for the treatment of myocardial infarction. At a mechanistic level, its objectives remain to replace lost cardiac cell mass with new functioning cardiomyocytes and vascular cells, thereby minimizing infarct size and scar formation, and improving clinical outcomes by preventing adverse left ventricular remodeling and recurrent ischemic events. Many different cell types, including pluripotent stem cells and various adult-derived progenitor cells, have been shown to have therapeutic potential in preclinical studies, while early phase human trial experience has provided divergent outcomes and fundamental lessons, emphasizing that there remain key issues to address and challenges to overcome before cell therapy can be applied to wider clinical practice. The purpose of this review is to provide a balanced update on recent seminal developments in this exciting field and look to the next important steps to ensure its forward progression.

Original languageEnglish (US)
JournalCurrent Cardiology Reports
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2014

Keywords

  • Acute coronary syndrome
  • Angiogenesis
  • Bone marrow
  • Cell therapy
  • Embryonic stem cells
  • Endothelial progenitor cells
  • Induced pluripotent stem cells
  • Mesenchymal stem cells
  • Mononuclear cells
  • Myocardial infarction
  • Myocardial regeneration
  • Myocardial repair
  • Pluripotent stem cells
  • Stem cells
  • STEMI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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