An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient

Sarah Narotzky, Cassie Kennedy, Fabien Maldonado

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 25-year-old woman, a never smoker with a history of heart-lung transplantation for World Health Organization group 1 pulmonary arterial hypertension performed 20 months prior to presentation, was evaluated for shortness of breath. Following transplantation, she was initiated on standard therapy of prednisone, tacrolimus, and azathioprine, along with routine antimicrobial prophylaxis. Her posttransplant course was complicated by persistent acute cellular rejection, as determined from a transbronchial biopsy specimen, without evidence of rejection in an endomyocardial biopsy specimen. The immunosuppressive medications were supplemented with pulse-dosed steroids, and the patient was transitioned from azathioprine to mycophenolate mofetil. Sirolimus was added 9 months prior to presentation. Three months prior to presentation, she was admitted for increasing oxygen requirements, shortness of breath, and bilateral infi ltrates on the CT scans of the chest.

Original languageEnglish (US)
Pages (from-to)e185-e188
JournalChest
Volume147
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Azathioprine
Respiratory Insufficiency
Dyspnea
Heart-Lung Transplantation
Mycophenolic Acid
Biopsy
Lung
Tacrolimus
Sirolimus
Immunosuppressive Agents
Prednisone
Pulmonary Hypertension
Pulse
Thorax
Transplantation
Steroids
Oxygen
Transplant Recipients
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient. / Narotzky, Sarah; Kennedy, Cassie; Maldonado, Fabien.

In: Chest, Vol. 147, No. 5, 01.05.2015, p. e185-e188.

Research output: Contribution to journalArticle

Narotzky, Sarah ; Kennedy, Cassie ; Maldonado, Fabien. / An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient. In: Chest. 2015 ; Vol. 147, No. 5. pp. e185-e188.
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