An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10

William G. Morice, Janice M. Hodnefield, Paul J. Kurtin, Curtis A. Hanson

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Characteristically, mantle cell lymphoma (MCL) expresses surface immunoglobulin (sIg), CD19, CD20, and CD5 and lacks CD10 and CD23. Rare CD5- MCL variants have been described. This report describes a case of leukemic MCL with morphologically and immunophenotypically distinct classic MCL and blastoid-variant MCL (BV-MCL) components. The classic MCL had typical morphologic features and immunophenotype (κ sIg light chain-restricted and CD5+; CD10- and CD23-). The BV-MCL had larger nuclei and open chromatin; these cells also were κ sIg light chain-restricted; however, they were CD10+ and CD5-. Fluorescence in situ hybridization studies demonstrated cyclin D1-immunoglobulin heavy chain gene fusion in both components; the bone marrow biopsy cellularity was replaced by CD10+ and cyclin D1+ and CD5- BV-MCL. This case illustrates the phenotypic heterogeneity of MCL and underscores the need for histopathologic correlation and, in some instances, ancillary genetic studies to accurately classify B-cell lymphomas.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalAmerican journal of clinical pathology
Volume122
Issue number1
DOIs
StatePublished - Jul 2004

Keywords

  • B-cell chronic lymphoproliferative disorders
  • Flow cytometric immunophenotyping
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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