An Ultrasound Vibro-Elastography Technique for Assessing Papilledema

Boran Zhou, John Chen, Arash Kazemi, Arthur J Sit, Xiaoming Zhang

Research output: Contribution to journalArticle

Abstract

Papilledemais optic nerve swelling caused by increased intracranial hypertension, which has the potential to cause significant vision loss. Papilledema from idiopathic intracranial hypertension (IIH) is typically bilateral and symmetric, but can be asymmetric and even unilateral. The purpose of this study was to develop ultrasound vibro-elastography (UVE) for non-invasive measurement of ocular tissue wave speed for patients with papilledema. A total of 9 patients with papilledema from IIH and 9 age-matched healthy control patients were enrolled in this study. A local, gentle, 0.1-s harmonic vibration was applied on the eyelid to generate wave propagation in the ocular tissue. We used 3 excitation frequencies of 100, 150 and 200 Hz to measure the wave speeds. A 6.4-MHz ultrasound probe was used to non-invasively measure wave propagation in the ocular structures. Wave speeds were analyzed in the posterior sclera of the maculae of the eyes. The magnitudes of wave speed at each frequency of the IIH patients’ posterior sclera were significantly higher than those of healthy patients. It was found that the magnitudes of wave speed at each frequency were statistically higher in the eyes with papilledema than in the contralateral eyes without papilledema for the patients with unilateral papilledema. UVE provides a non-invasive technique to measure the wave speed of posterior sclera, which may be useful for assessing patients with papilledema.

Original languageEnglish (US)
JournalUltrasound in Medicine and Biology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Elasticity Imaging Techniques
Papilledema
hypertension
Sclera
Pseudotumor Cerebri
wave propagation
Intracranial Hypertension
nerves
Eyelids
Optic Nerve
Vibration
swelling
optics
harmonics
vibration
probes
causes

Keywords

  • Intracranial hypertension
  • Papilledema
  • Posterior sclera
  • Ultrasound vibro-elastography
  • wave speed

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

An Ultrasound Vibro-Elastography Technique for Assessing Papilledema. / Zhou, Boran; Chen, John; Kazemi, Arash; Sit, Arthur J; Zhang, Xiaoming.

In: Ultrasound in Medicine and Biology, 01.01.2019.

Research output: Contribution to journalArticle

@article{96ae9c4e59cb4c75a32a1cf027bc5b9a,
title = "An Ultrasound Vibro-Elastography Technique for Assessing Papilledema",
abstract = "Papilledemais optic nerve swelling caused by increased intracranial hypertension, which has the potential to cause significant vision loss. Papilledema from idiopathic intracranial hypertension (IIH) is typically bilateral and symmetric, but can be asymmetric and even unilateral. The purpose of this study was to develop ultrasound vibro-elastography (UVE) for non-invasive measurement of ocular tissue wave speed for patients with papilledema. A total of 9 patients with papilledema from IIH and 9 age-matched healthy control patients were enrolled in this study. A local, gentle, 0.1-s harmonic vibration was applied on the eyelid to generate wave propagation in the ocular tissue. We used 3 excitation frequencies of 100, 150 and 200 Hz to measure the wave speeds. A 6.4-MHz ultrasound probe was used to non-invasively measure wave propagation in the ocular structures. Wave speeds were analyzed in the posterior sclera of the maculae of the eyes. The magnitudes of wave speed at each frequency of the IIH patients’ posterior sclera were significantly higher than those of healthy patients. It was found that the magnitudes of wave speed at each frequency were statistically higher in the eyes with papilledema than in the contralateral eyes without papilledema for the patients with unilateral papilledema. UVE provides a non-invasive technique to measure the wave speed of posterior sclera, which may be useful for assessing patients with papilledema.",
keywords = "Intracranial hypertension, Papilledema, Posterior sclera, Ultrasound vibro-elastography, wave speed",
author = "Boran Zhou and John Chen and Arash Kazemi and Sit, {Arthur J} and Xiaoming Zhang",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.ultrasmedbio.2019.04.029",
language = "English (US)",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - An Ultrasound Vibro-Elastography Technique for Assessing Papilledema

AU - Zhou, Boran

AU - Chen, John

AU - Kazemi, Arash

AU - Sit, Arthur J

AU - Zhang, Xiaoming

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Papilledemais optic nerve swelling caused by increased intracranial hypertension, which has the potential to cause significant vision loss. Papilledema from idiopathic intracranial hypertension (IIH) is typically bilateral and symmetric, but can be asymmetric and even unilateral. The purpose of this study was to develop ultrasound vibro-elastography (UVE) for non-invasive measurement of ocular tissue wave speed for patients with papilledema. A total of 9 patients with papilledema from IIH and 9 age-matched healthy control patients were enrolled in this study. A local, gentle, 0.1-s harmonic vibration was applied on the eyelid to generate wave propagation in the ocular tissue. We used 3 excitation frequencies of 100, 150 and 200 Hz to measure the wave speeds. A 6.4-MHz ultrasound probe was used to non-invasively measure wave propagation in the ocular structures. Wave speeds were analyzed in the posterior sclera of the maculae of the eyes. The magnitudes of wave speed at each frequency of the IIH patients’ posterior sclera were significantly higher than those of healthy patients. It was found that the magnitudes of wave speed at each frequency were statistically higher in the eyes with papilledema than in the contralateral eyes without papilledema for the patients with unilateral papilledema. UVE provides a non-invasive technique to measure the wave speed of posterior sclera, which may be useful for assessing patients with papilledema.

AB - Papilledemais optic nerve swelling caused by increased intracranial hypertension, which has the potential to cause significant vision loss. Papilledema from idiopathic intracranial hypertension (IIH) is typically bilateral and symmetric, but can be asymmetric and even unilateral. The purpose of this study was to develop ultrasound vibro-elastography (UVE) for non-invasive measurement of ocular tissue wave speed for patients with papilledema. A total of 9 patients with papilledema from IIH and 9 age-matched healthy control patients were enrolled in this study. A local, gentle, 0.1-s harmonic vibration was applied on the eyelid to generate wave propagation in the ocular tissue. We used 3 excitation frequencies of 100, 150 and 200 Hz to measure the wave speeds. A 6.4-MHz ultrasound probe was used to non-invasively measure wave propagation in the ocular structures. Wave speeds were analyzed in the posterior sclera of the maculae of the eyes. The magnitudes of wave speed at each frequency of the IIH patients’ posterior sclera were significantly higher than those of healthy patients. It was found that the magnitudes of wave speed at each frequency were statistically higher in the eyes with papilledema than in the contralateral eyes without papilledema for the patients with unilateral papilledema. UVE provides a non-invasive technique to measure the wave speed of posterior sclera, which may be useful for assessing patients with papilledema.

KW - Intracranial hypertension

KW - Papilledema

KW - Posterior sclera

KW - Ultrasound vibro-elastography

KW - wave speed

UR - http://www.scopus.com/inward/record.url?scp=85065821747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065821747&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2019.04.029

DO - 10.1016/j.ultrasmedbio.2019.04.029

M3 - Article

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

ER -