An overview of the diagnosis and pharmacologic treatment of migraine

D. J. Capobianco, W. P. Cheshire, J. K. Campbell

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Migraine, an episodic headache disorder, is one of the most common complaints encountered by primary-care physicians and neurologists. Nevertheless, it remains underdiagnosed and undertreated. Rational migraine treatment necessitates an accurate diagnosis, identification and removal of potential triggering factors, and, frequently, pharmacologic intervention. Effective management also includes establishing realistic expectations, patient reassurance, and education. The choice of medication (abortive, symptomatic) for an acute attack depends on such factors as the severity of the attack, presence or absence of vomiting, time of onset to peak pain, rate of bioavailability of the drug, comorbid medical conditions, and side-effect profile. Effective agents for acute attacks include simple or combination analgesics, nonsteroidal anti-inflammatory drugs, ergot derivatives, selective serotonin agonists, and antiemetics. Opioid analgesics are unnecessary for most patients. The choice of preventive (prophylactic, interval) medication depends primarily on comorbid medical conditions and side-effect profile. Useful preventive agents include β-adrenergic blockers, calcium channel blockers, tricyclic antidepressants, anticonvulsant medications, and serotonin antagonists.

Original languageEnglish (US)
Pages (from-to)1055-1066
Number of pages12
JournalMayo Clinic Proceedings
Volume71
Issue number11
StatePublished - 1996

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Migraine Disorders
Serotonin Receptor Agonists
Serotonin Antagonists
Headache Disorders
Adrenergic Antagonists
Antiemetics
Tricyclic Antidepressive Agents
Calcium Channel Blockers
Primary Care Physicians
Non-Steroidal Anti-Inflammatory Agents
Patient Education
Pharmaceutical Preparations
Anticonvulsants
Opioid Analgesics
Biological Availability
Vomiting
Pain
Therapeutics
Neurologists

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Capobianco, D. J., Cheshire, W. P., & Campbell, J. K. (1996). An overview of the diagnosis and pharmacologic treatment of migraine. Mayo Clinic Proceedings, 71(11), 1055-1066.

An overview of the diagnosis and pharmacologic treatment of migraine. / Capobianco, D. J.; Cheshire, W. P.; Campbell, J. K.

In: Mayo Clinic Proceedings, Vol. 71, No. 11, 1996, p. 1055-1066.

Research output: Contribution to journalArticle

Capobianco, DJ, Cheshire, WP & Campbell, JK 1996, 'An overview of the diagnosis and pharmacologic treatment of migraine', Mayo Clinic Proceedings, vol. 71, no. 11, pp. 1055-1066.
Capobianco DJ, Cheshire WP, Campbell JK. An overview of the diagnosis and pharmacologic treatment of migraine. Mayo Clinic Proceedings. 1996;71(11):1055-1066.
Capobianco, D. J. ; Cheshire, W. P. ; Campbell, J. K. / An overview of the diagnosis and pharmacologic treatment of migraine. In: Mayo Clinic Proceedings. 1996 ; Vol. 71, No. 11. pp. 1055-1066.
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