An organ system-based approach to prognosis in advanced melanoma

Shernan G. Holtan, Aaron Mansfield, Douglas J. Creedon, Wendy K. Nevala, Paul Haluska, Alexey A. Leontovich, Svetomir Nenad Markovic

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous models to study the biology of melanoma have focused on individual factors, such as proliferative and invasive capacity, the microenvironment, angiogenesis, or systemic immune dysfunction. However, all of these factors contribute to melanoma progression in concert. One physiologic phenomenon that typifies the coordination of these processes is placental development, characterized by trophoblast proliferation, invasion into decidual tissues, angiogenesis, and transient organ systembased immune evasion. Herein, we explore expression of 34 proteins involved in placentation and determine their association with an established prognostic factor, tumor infiltrating lymphocytes (TILs), in a 118-patient tumor microarray (TMA). Melanoma expression of CD58 and galectin-9 independently predicted for a favorable prognosis. Patients could be categorized into three clusters based upon patterns of protein expression and TILs. Patients in Cluster 2 demonstrated frequent TILs and superior overall survival. Pathway enrichment using MetaCore from GeneGo, a Thompson Reuters company, showed that TIMP2 and CD44 were expressed more frequently within Cluster 2 patients, suggesting a potential association with TILs. A subset of melanoma patients appear to lack an organized immune response to the tumor, which portends a poor prognosis.

Original languageEnglish (US)
Pages (from-to)2723-2733
Number of pages11
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number8
StatePublished - Jun 1 2012

Fingerprint

Tumor-Infiltrating Lymphocytes
Tumors
Melanoma
Lymphocytes
Placentation
Galectins
Immune Evasion
Association reactions
Trophoblasts
Microarrays
Neoplasms
Proteins
Survival
Tissue
Industry

Keywords

  • B7H1-
  • CD44
  • CD58
  • Galectin-9
  • Melanoma
  • Placenta
  • Systems biology
  • TIMP2
  • Tissue microarray
  • Tumor infiltrating lymphocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Holtan, S. G., Mansfield, A., Creedon, D. J., Nevala, W. K., Haluska, P., Leontovich, A. A., & Markovic, S. N. (2012). An organ system-based approach to prognosis in advanced melanoma. Frontiers in Bioscience - Elite, 4 E(8), 2723-2733.

An organ system-based approach to prognosis in advanced melanoma. / Holtan, Shernan G.; Mansfield, Aaron; Creedon, Douglas J.; Nevala, Wendy K.; Haluska, Paul; Leontovich, Alexey A.; Markovic, Svetomir Nenad.

In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 8, 01.06.2012, p. 2723-2733.

Research output: Contribution to journalArticle

Holtan, SG, Mansfield, A, Creedon, DJ, Nevala, WK, Haluska, P, Leontovich, AA & Markovic, SN 2012, 'An organ system-based approach to prognosis in advanced melanoma', Frontiers in Bioscience - Elite, vol. 4 E, no. 8, pp. 2723-2733.
Holtan SG, Mansfield A, Creedon DJ, Nevala WK, Haluska P, Leontovich AA et al. An organ system-based approach to prognosis in advanced melanoma. Frontiers in Bioscience - Elite. 2012 Jun 1;4 E(8):2723-2733.
Holtan, Shernan G. ; Mansfield, Aaron ; Creedon, Douglas J. ; Nevala, Wendy K. ; Haluska, Paul ; Leontovich, Alexey A. ; Markovic, Svetomir Nenad. / An organ system-based approach to prognosis in advanced melanoma. In: Frontiers in Bioscience - Elite. 2012 ; Vol. 4 E, No. 8. pp. 2723-2733.
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