An international Ki67 reproducibility study in adrenal cortical Carcinoma

Thomas G. Papathomas, Eugenio Pucci, Thomas J. Giordano, Hao Lu, Eleonora Duregon, Marco Volante, Mauro Papotti, Ricardo V. Lloyd, Arthur S. Tischler, Francien H. Van Nederveen, Vania Nose, Lori Erickson, Ozgur Mete, Sylvia L. Asa, John Turchini, Anthony J. Gill, Xavier Matias-Guiu, Kassiani Skordilis, Timothy J. Stephenson, Frederique TissierRichard A. Feelders, Marcel Smid, Alex Nigg, Esther Korpershoek, Peter J. Van Der Spek, Winand N M Dinjens, Andrew P. Stubbs, Ronald R. De Krijger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variability among endocrine pathologists using a web-based virtual microscopy approach. Ki67-stained slides of 76 adrenocortical carcinomas were analyzed independently by 14 observers, each according to their method of preference including eyeballing, formal manual counting, and digital image analysis. The interobserver variation was statistically significant (P

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume40
Issue number4
DOIs
StatePublished - 2016

Fingerprint

Adrenocortical Carcinoma
Observer Variation
Microscopy
Therapeutics
Pathologists

Keywords

  • Adrenal cortical carcinoma
  • Digital pathology
  • Interobserver variation
  • Ki67 labeling index
  • Proliferation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Papathomas, T. G., Pucci, E., Giordano, T. J., Lu, H., Duregon, E., Volante, M., ... De Krijger, R. R. (2016). An international Ki67 reproducibility study in adrenal cortical Carcinoma. American Journal of Surgical Pathology, 40(4), 569-576. https://doi.org/10.1097/PAS.0000000000000574

An international Ki67 reproducibility study in adrenal cortical Carcinoma. / Papathomas, Thomas G.; Pucci, Eugenio; Giordano, Thomas J.; Lu, Hao; Duregon, Eleonora; Volante, Marco; Papotti, Mauro; Lloyd, Ricardo V.; Tischler, Arthur S.; Van Nederveen, Francien H.; Nose, Vania; Erickson, Lori; Mete, Ozgur; Asa, Sylvia L.; Turchini, John; Gill, Anthony J.; Matias-Guiu, Xavier; Skordilis, Kassiani; Stephenson, Timothy J.; Tissier, Frederique; Feelders, Richard A.; Smid, Marcel; Nigg, Alex; Korpershoek, Esther; Van Der Spek, Peter J.; Dinjens, Winand N M; Stubbs, Andrew P.; De Krijger, Ronald R.

In: American Journal of Surgical Pathology, Vol. 40, No. 4, 2016, p. 569-576.

Research output: Contribution to journalArticle

Papathomas, TG, Pucci, E, Giordano, TJ, Lu, H, Duregon, E, Volante, M, Papotti, M, Lloyd, RV, Tischler, AS, Van Nederveen, FH, Nose, V, Erickson, L, Mete, O, Asa, SL, Turchini, J, Gill, AJ, Matias-Guiu, X, Skordilis, K, Stephenson, TJ, Tissier, F, Feelders, RA, Smid, M, Nigg, A, Korpershoek, E, Van Der Spek, PJ, Dinjens, WNM, Stubbs, AP & De Krijger, RR 2016, 'An international Ki67 reproducibility study in adrenal cortical Carcinoma', American Journal of Surgical Pathology, vol. 40, no. 4, pp. 569-576. https://doi.org/10.1097/PAS.0000000000000574
Papathomas, Thomas G. ; Pucci, Eugenio ; Giordano, Thomas J. ; Lu, Hao ; Duregon, Eleonora ; Volante, Marco ; Papotti, Mauro ; Lloyd, Ricardo V. ; Tischler, Arthur S. ; Van Nederveen, Francien H. ; Nose, Vania ; Erickson, Lori ; Mete, Ozgur ; Asa, Sylvia L. ; Turchini, John ; Gill, Anthony J. ; Matias-Guiu, Xavier ; Skordilis, Kassiani ; Stephenson, Timothy J. ; Tissier, Frederique ; Feelders, Richard A. ; Smid, Marcel ; Nigg, Alex ; Korpershoek, Esther ; Van Der Spek, Peter J. ; Dinjens, Winand N M ; Stubbs, Andrew P. ; De Krijger, Ronald R. / An international Ki67 reproducibility study in adrenal cortical Carcinoma. In: American Journal of Surgical Pathology. 2016 ; Vol. 40, No. 4. pp. 569-576.
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