An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity

Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery, Ward A. Ortmann, Karl J. Espe, Jill Novitzke, Steven R Ytterberg, Peter K. Gregersen, Timothy W. Behrens, Ann M. Reed

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalMolecular Medicine
Volume13
Issue number1-2
DOIs
StatePublished - Jan 2007

Fingerprint

Dermatomyositis
Interferons
Interferon Type I
Muscles
Blood Cells
Genes
Oxidative Phosphorylation
Gene Expression Profiling
Systemic Lupus Erythematosus
Blood Proteins
Biopsy
Serum
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Baechler, E. C., Bauer, J. W., Slattery, C. A., Ortmann, W. A., Espe, K. J., Novitzke, J., ... Reed, A. M. (2007). An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. Molecular Medicine, 13(1-2), 59-68. https://doi.org/10.2119/2006-00085.Baechler

An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. / Baechler, Emily C.; Bauer, Jason W.; Slattery, Catherine A.; Ortmann, Ward A.; Espe, Karl J.; Novitzke, Jill; Ytterberg, Steven R; Gregersen, Peter K.; Behrens, Timothy W.; Reed, Ann M.

In: Molecular Medicine, Vol. 13, No. 1-2, 01.2007, p. 59-68.

Research output: Contribution to journalArticle

Baechler, EC, Bauer, JW, Slattery, CA, Ortmann, WA, Espe, KJ, Novitzke, J, Ytterberg, SR, Gregersen, PK, Behrens, TW & Reed, AM 2007, 'An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity', Molecular Medicine, vol. 13, no. 1-2, pp. 59-68. https://doi.org/10.2119/2006-00085.Baechler
Baechler, Emily C. ; Bauer, Jason W. ; Slattery, Catherine A. ; Ortmann, Ward A. ; Espe, Karl J. ; Novitzke, Jill ; Ytterberg, Steven R ; Gregersen, Peter K. ; Behrens, Timothy W. ; Reed, Ann M. / An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. In: Molecular Medicine. 2007 ; Vol. 13, No. 1-2. pp. 59-68.
@article{a2e0dab54aee41138c35c690d91eaec4,
title = "An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity",
abstract = "Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature.",
author = "Baechler, {Emily C.} and Bauer, {Jason W.} and Slattery, {Catherine A.} and Ortmann, {Ward A.} and Espe, {Karl J.} and Jill Novitzke and Ytterberg, {Steven R} and Gregersen, {Peter K.} and Behrens, {Timothy W.} and Reed, {Ann M.}",
year = "2007",
month = "1",
doi = "10.2119/2006-00085.Baechler",
language = "English (US)",
volume = "13",
pages = "59--68",
journal = "Molecular Medicine",
issn = "1076-1551",
publisher = "Feinstein Institute for Medical Research",
number = "1-2",

}

TY - JOUR

T1 - An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity

AU - Baechler, Emily C.

AU - Bauer, Jason W.

AU - Slattery, Catherine A.

AU - Ortmann, Ward A.

AU - Espe, Karl J.

AU - Novitzke, Jill

AU - Ytterberg, Steven R

AU - Gregersen, Peter K.

AU - Behrens, Timothy W.

AU - Reed, Ann M.

PY - 2007/1

Y1 - 2007/1

N2 - Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature.

AB - Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature.

UR - http://www.scopus.com/inward/record.url?scp=34248998426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248998426&partnerID=8YFLogxK

U2 - 10.2119/2006-00085.Baechler

DO - 10.2119/2006-00085.Baechler

M3 - Article

C2 - 17515957

AN - SCOPUS:34248998426

VL - 13

SP - 59

EP - 68

JO - Molecular Medicine

JF - Molecular Medicine

SN - 1076-1551

IS - 1-2

ER -