An instrument for estimating the 6-month survival probability after whole-brain irradiation alone for cerebral metastases from gynecological cancer

Stefan Janssen, Heinke C. Hansen, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background/Aim: Patients with cerebral metastases from gynecological cancer who receive whole-brain irradiation (WBI) alone require personalized therapy. This study contributes to personalized care by creating an instrument to predict 6-month survival probability. Patients and Methods: In 49 patients, six pre-treatment variables, namely age, Eastern Cooperative Oncology Group performance score (ECOG-PS), primary tumor type, number of cerebral metastases, metastasis outside the brain, and interval between diagnosis of gynecological cancer and WBI, were analyzed for survival. Results: Of the six pre-treatment variables, ECOG-PS was significantly associated with survival (p=0.014) and metastasis outside the brain showed a trend for association (p=0.096). Six-month survival rates divided by 10 resulted in scores of 0, 2 or 7 points for ECOG-PS and of 2 or 7 points for metastasis outside the brain. Scores for individual patients were 2, 4, 7, 9 or 14 points. Three groups were created, those with 2-7, 9 and 14 points, with 6-month survival rates of 10%, 53% and 100%, respectively (p=0.004). Conclusion: An instrument was designed to predict the 6-month survival of patients receiving WBI for cerebral metastases from gynecological cancer and facilitate personalized care.

Original languageEnglish (US)
Pages (from-to)3753-3756
Number of pages4
JournalAnticancer Research
Volume38
Issue number6
DOIs
StatePublished - Jun 1 2018

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Keywords

  • 6-month survival probability
  • Brain metastases
  • Gynecological cancer
  • Prognostic instrument
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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