An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans

Ewa Świerblewska, Dagmara Hering, Tomas Kara, Katarzyna Kunicka, Piotr Kruszewski, Leszek Bieniaszewski, Pierre Boutouyrie, Virend Somers, Krzysztof Narkiewicz

Research output: Contribution to journalArticle

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Abstract

Objective: Carotid-femoral pulse wave velocity (PWV) has been shown to be a powerful predictor of cardiovascular morbidity and mortality. Sympathetic neural mechanisms may have a stiffening influence on arterial mechanical properties. The relationship between direct measures of sympathetic traffic and PWV in healthy humans has not been previously studied. We, therefore, tested the hypothesis that PWV is independently linked to muscle sympathetic nerve activity (MSNA) in normal individuals. Methods: We measured MSNA (microneurography), PWV (Complior device), heart rate and blood pressure in 25 healthy male participants (mean age 43 ± 10 years). Results: PWV correlated significantly with age (r = 0.63, P < 0.001), SBP (r = 0.43, P < 0.05) and MSNA (r = 0.43, P < 0.05) but not with BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or DBP. Robust multiple linear regression analysis revealed that only age and MSNA were linked independently to PWV (r2 = 0.62, P < 0.001), explaining 39 and 25% of its variance, respectively. After adjustment of PWV for age and SBP, we further divided individuals into 'excessive' PWV (i.e. higher than expected from age and SBP) and 'optimal' PWV (i.e. lower than expected). BMI and blood pressure were similar in both subgroups. Individuals with excessive PWV had significantly greater MSNA than individuals with optimal PWV (30 ± 10 vs. 18 ± 11 bursts/min, P = 0.01). Conclusion: This study provides the first evidence that PWV is linked to MSNA in normal humans. The relationship between MSNA and PWV is independent of age, BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or blood pressure.

Original languageEnglish (US)
Pages (from-to)979-984
Number of pages6
JournalJournal of Hypertension
Volume28
Issue number5
DOIs
StatePublished - May 2010

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Pulse Wave Analysis
Muscles
Blood Pressure
Waist-Hip Ratio
Heart Rate
Waist Circumference
Thigh
Linear Models
Healthy Volunteers

Keywords

  • Arterial stiffness
  • Autonomic nervous system
  • Blood pressure
  • Left ventricular function
  • Pulse wave velocity
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Świerblewska, E., Hering, D., Kara, T., Kunicka, K., Kruszewski, P., Bieniaszewski, L., ... Narkiewicz, K. (2010). An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans. Journal of Hypertension, 28(5), 979-984. https://doi.org/10.1097/HJH.0b013e328336ed9a

An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans. / Świerblewska, Ewa; Hering, Dagmara; Kara, Tomas; Kunicka, Katarzyna; Kruszewski, Piotr; Bieniaszewski, Leszek; Boutouyrie, Pierre; Somers, Virend; Narkiewicz, Krzysztof.

In: Journal of Hypertension, Vol. 28, No. 5, 05.2010, p. 979-984.

Research output: Contribution to journalArticle

Świerblewska, E, Hering, D, Kara, T, Kunicka, K, Kruszewski, P, Bieniaszewski, L, Boutouyrie, P, Somers, V & Narkiewicz, K 2010, 'An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans', Journal of Hypertension, vol. 28, no. 5, pp. 979-984. https://doi.org/10.1097/HJH.0b013e328336ed9a
Świerblewska, Ewa ; Hering, Dagmara ; Kara, Tomas ; Kunicka, Katarzyna ; Kruszewski, Piotr ; Bieniaszewski, Leszek ; Boutouyrie, Pierre ; Somers, Virend ; Narkiewicz, Krzysztof. / An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans. In: Journal of Hypertension. 2010 ; Vol. 28, No. 5. pp. 979-984.
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AB - Objective: Carotid-femoral pulse wave velocity (PWV) has been shown to be a powerful predictor of cardiovascular morbidity and mortality. Sympathetic neural mechanisms may have a stiffening influence on arterial mechanical properties. The relationship between direct measures of sympathetic traffic and PWV in healthy humans has not been previously studied. We, therefore, tested the hypothesis that PWV is independently linked to muscle sympathetic nerve activity (MSNA) in normal individuals. Methods: We measured MSNA (microneurography), PWV (Complior device), heart rate and blood pressure in 25 healthy male participants (mean age 43 ± 10 years). Results: PWV correlated significantly with age (r = 0.63, P < 0.001), SBP (r = 0.43, P < 0.05) and MSNA (r = 0.43, P < 0.05) but not with BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or DBP. Robust multiple linear regression analysis revealed that only age and MSNA were linked independently to PWV (r2 = 0.62, P < 0.001), explaining 39 and 25% of its variance, respectively. After adjustment of PWV for age and SBP, we further divided individuals into 'excessive' PWV (i.e. higher than expected from age and SBP) and 'optimal' PWV (i.e. lower than expected). BMI and blood pressure were similar in both subgroups. Individuals with excessive PWV had significantly greater MSNA than individuals with optimal PWV (30 ± 10 vs. 18 ± 11 bursts/min, P = 0.01). Conclusion: This study provides the first evidence that PWV is linked to MSNA in normal humans. The relationship between MSNA and PWV is independent of age, BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or blood pressure.

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KW - Pulse wave velocity

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