An immunocompromised child with bloodstream infection caused by two Escherichia coli strains, one harboring NDM-5 and the other harboring OXA-48-like carbapenemase

M. Earth Hasassri, Thomas G. Boyce, Andrew Norgan, Scott A. Cunningham, Patricio R. Jeraldo, Scott Weissman, Robin Patel, Ritu Banerjee, Jason M. Pogue, Keith S. Kaye

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was blaNDM positive, the other demonstrated meropenem susceptibility yet harbored blaOXA181 (which encodes a blaOXA48-like enzyme). This report highlights the challenge of laboratory detection of blaOXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.

Original languageEnglish (US)
Pages (from-to)3270-3275
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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