TY - JOUR
T1 - An evidence-based medicine approach to beta-blocker therapy in patients with cirrhosis
AU - Talwalkar, Jayant A.
AU - Kamath, Patrick S.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Disease management strategies have gained attention in recent years because of their potential to improve health-related quality of life and prevent excessive resource use. Despite recognition as an important cause of mortality, cirrhosis with portal hypertension has not been widely discussed as a condition amenable to planned care management. Given the effect of variceal hemorrhage as the most immediate life-threatening complication of portal hypertension, a number of high-quality controlled clinical trials have confirmed the efficacy of beta-blocker therapy for primary and secondary prophylaxis. Despite the existence of practice guidelines that incorporate this information, specific clinical scenarios that demand consideration for beta-blocker therapy have not been well described. In this article, a number of hypothetical patient-based cases drawn from the authors' experiences are utilized to illustrate these issues.
AB - Disease management strategies have gained attention in recent years because of their potential to improve health-related quality of life and prevent excessive resource use. Despite recognition as an important cause of mortality, cirrhosis with portal hypertension has not been widely discussed as a condition amenable to planned care management. Given the effect of variceal hemorrhage as the most immediate life-threatening complication of portal hypertension, a number of high-quality controlled clinical trials have confirmed the efficacy of beta-blocker therapy for primary and secondary prophylaxis. Despite the existence of practice guidelines that incorporate this information, specific clinical scenarios that demand consideration for beta-blocker therapy have not been well described. In this article, a number of hypothetical patient-based cases drawn from the authors' experiences are utilized to illustrate these issues.
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U2 - 10.1016/j.amjmed.2004.03.006
DO - 10.1016/j.amjmed.2004.03.006
M3 - Review article
C2 - 15144913
AN - SCOPUS:2442608935
SN - 0002-9343
VL - 116
SP - 759
EP - 766
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 11
ER -