An Evidence-Based Approach to Studies in Cirrhosis and Portal Hypertension: Medical Management of Mild to Moderate Ascites

Jayant A. Talwalkar

Research output: Contribution to journalArticle

3 Scopus citations


Previous articles in this series have examined the critical appraisal of isolated structured clinical questions using the framework of evidence-based medicine. When patients are identified with a disease-specific process, however, an integrated approach for addressing multiple questions is required. This article, the sixth in the evidence-based medicine series for this journal, integrates critical appraisal techniques to examine the decision-making process used when evaluating a patient with cirrhosis and new-onset mild to moderate ascites. In the following clinical scenario, an approach is described for determining prognosis after the development of ascites and whether salt restriction and oral diuretics are effective therapies. The format is similar to other evidence-based medicine articles published in the Journal of the American Medical Association. The evidence-based medicine concepts have been expanded from previous articles, and examples from the hepatology literature have been used.

Original languageEnglish (US)
Pages (from-to)474-479
Number of pages6
JournalClinical Gastroenterology and Hepatology
Issue number6
StatePublished - Nov 2003


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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