An Evaluation of Analgesic Regimens for Abdominal Surgery in Mice

Kathryn E. Hayes, John A. Raucci, Naomi M. Gades, Linda A. Toth

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

This study was designed to evaluate the efficacy of several analgesic regimens for use after intraperitoneal implantation of telemetry transmitters in mice. The lengths of time required for postoperative recovery of food and water intake, locomotor activity, and core temperature of mice that did not receive postsurgical analgesic medication were compared to those of mice that were given either an analgesic in the drinking water or buprenorphine injections. Many measured variables were not substantially altered by analgesic medications. However, ibuprofen-treated mice demonstrated significantly greater locomotor activity on days 2 through 5 after surgery and a more rapid return to stable postsurgical levels of activity and water intake as compared to those in untreated mice. These changes are consistent with potential analgesic efficacy of the ibuprofen treatment regimen. Buprenorphine injections elicited hyperactivity, hyperthermia, and reduced food and water intake during both the immediate postsurgical recovery period and after apparent recuperation from surgery, as compared to effects observed in saline-treated mice. Evaluating the effect of analgesic regimens on postsurgical changes in physiologic and behavioral variables can be useful in assessing the efficacy of analgesic treatments, but some changes may indicate pharmacologic effects that do not reflect pain relief.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalContemporary Topics in Laboratory Animal Science
Volume39
Issue number6
StatePublished - Nov 2000

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'An Evaluation of Analgesic Regimens for Abdominal Surgery in Mice'. Together they form a unique fingerprint.

Cite this