An estimated glomerular filtration rate equation for the full age spectrum

Hans Pottel, Liesbeth Hoste, Laurence Dubourg, Natalie Ebert, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J. Lamb, Andrew D Rule, Stephen T Turner, Richard J. Glassock, Vandrea De Souza, Luciano Selistre, Christophe Mariat, Frank Martens, Pierre Delanaye

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children,

Original languageEnglish (US)
Pages (from-to)798-806
Number of pages9
JournalNephrology Dialysis Transplantation
Volume31
Issue number5
DOIs
StatePublished - May 1 2016

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Keywords

  • development and validation
  • FAS eGFR equation
  • healthy and kidney-diseased subjects

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Pottel, H., Hoste, L., Dubourg, L., Ebert, N., Schaeffner, E., Eriksen, B. O., Melsom, T., Lamb, E. J., Rule, A. D., Turner, S. T., Glassock, R. J., De Souza, V., Selistre, L., Mariat, C., Martens, F., & Delanaye, P. (2016). An estimated glomerular filtration rate equation for the full age spectrum. Nephrology Dialysis Transplantation, 31(5), 798-806. https://doi.org/10.1093/ndt/gfv454