An estimated glomerular filtration rate equation for the full age spectrum

Hans Pottel, Liesbeth Hoste, Laurence Dubourg, Natalie Ebert, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J. Lamb, Andrew D Rule, Stephen T Turner, Richard J. Glassock, Vandrea De Souza, Luciano Selistre, Christophe Mariat, Frank Martens, Pierre Delanaye

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children,

Original languageEnglish (US)
Pages (from-to)798-806
Number of pages9
JournalNephrology Dialysis Transplantation
Volume31
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Glomerular Filtration Rate
Creatinine
Serum
Kidney Diseases
Berlin
Chronic Renal Insufficiency
Epidemiology
Pediatrics
Kidney
Research
Population

Keywords

  • development and validation
  • FAS eGFR equation
  • healthy and kidney-diseased subjects

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Pottel, H., Hoste, L., Dubourg, L., Ebert, N., Schaeffner, E., Eriksen, B. O., ... Delanaye, P. (2016). An estimated glomerular filtration rate equation for the full age spectrum. Nephrology Dialysis Transplantation, 31(5), 798-806. https://doi.org/10.1093/ndt/gfv454

An estimated glomerular filtration rate equation for the full age spectrum. / Pottel, Hans; Hoste, Liesbeth; Dubourg, Laurence; Ebert, Natalie; Schaeffner, Elke; Eriksen, Bjørn Odvar; Melsom, Toralf; Lamb, Edmund J.; Rule, Andrew D; Turner, Stephen T; Glassock, Richard J.; De Souza, Vandrea; Selistre, Luciano; Mariat, Christophe; Martens, Frank; Delanaye, Pierre.

In: Nephrology Dialysis Transplantation, Vol. 31, No. 5, 01.05.2016, p. 798-806.

Research output: Contribution to journalArticle

Pottel, H, Hoste, L, Dubourg, L, Ebert, N, Schaeffner, E, Eriksen, BO, Melsom, T, Lamb, EJ, Rule, AD, Turner, ST, Glassock, RJ, De Souza, V, Selistre, L, Mariat, C, Martens, F & Delanaye, P 2016, 'An estimated glomerular filtration rate equation for the full age spectrum', Nephrology Dialysis Transplantation, vol. 31, no. 5, pp. 798-806. https://doi.org/10.1093/ndt/gfv454
Pottel H, Hoste L, Dubourg L, Ebert N, Schaeffner E, Eriksen BO et al. An estimated glomerular filtration rate equation for the full age spectrum. Nephrology Dialysis Transplantation. 2016 May 1;31(5):798-806. https://doi.org/10.1093/ndt/gfv454
Pottel, Hans ; Hoste, Liesbeth ; Dubourg, Laurence ; Ebert, Natalie ; Schaeffner, Elke ; Eriksen, Bjørn Odvar ; Melsom, Toralf ; Lamb, Edmund J. ; Rule, Andrew D ; Turner, Stephen T ; Glassock, Richard J. ; De Souza, Vandrea ; Selistre, Luciano ; Mariat, Christophe ; Martens, Frank ; Delanaye, Pierre. / An estimated glomerular filtration rate equation for the full age spectrum. In: Nephrology Dialysis Transplantation. 2016 ; Vol. 31, No. 5. pp. 798-806.
@article{6566bad0ba33440789df3f4fed2b611d,
title = "An estimated glomerular filtration rate equation for the full age spectrum",
abstract = "BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children,",
keywords = "development and validation, FAS eGFR equation, healthy and kidney-diseased subjects",
author = "Hans Pottel and Liesbeth Hoste and Laurence Dubourg and Natalie Ebert and Elke Schaeffner and Eriksen, {Bj{\o}rn Odvar} and Toralf Melsom and Lamb, {Edmund J.} and Rule, {Andrew D} and Turner, {Stephen T} and Glassock, {Richard J.} and {De Souza}, Vandrea and Luciano Selistre and Christophe Mariat and Frank Martens and Pierre Delanaye",
year = "2016",
month = "5",
day = "1",
doi = "10.1093/ndt/gfv454",
language = "English (US)",
volume = "31",
pages = "798--806",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - An estimated glomerular filtration rate equation for the full age spectrum

AU - Pottel, Hans

AU - Hoste, Liesbeth

AU - Dubourg, Laurence

AU - Ebert, Natalie

AU - Schaeffner, Elke

AU - Eriksen, Bjørn Odvar

AU - Melsom, Toralf

AU - Lamb, Edmund J.

AU - Rule, Andrew D

AU - Turner, Stephen T

AU - Glassock, Richard J.

AU - De Souza, Vandrea

AU - Selistre, Luciano

AU - Mariat, Christophe

AU - Martens, Frank

AU - Delanaye, Pierre

PY - 2016/5/1

Y1 - 2016/5/1

N2 - BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children,

AB - BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children,

KW - development and validation

KW - FAS eGFR equation

KW - healthy and kidney-diseased subjects

UR - http://www.scopus.com/inward/record.url?scp=84965096925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965096925&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfv454

DO - 10.1093/ndt/gfv454

M3 - Article

VL - 31

SP - 798

EP - 806

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 5

ER -