An estimated glomerular filtration rate equation for the full age spectrum

Hans Pottel, Liesbeth Hoste, Laurence Dubourg, Natalie Ebert, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J. Lamb, Andrew D. Rule, Stephen T. Turner, Richard J. Glassock, Vandrea De Souza, Luciano Selistre, Christophe Mariat, Frank Martens, Pierre Delanaye

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

BackgroundGlomerular filtration rate (GFR) is accepted as the best indicator of kidney function and is commonly estimated from serum creatinine (SCr)-based equations. Separate equations have been developed for children (Schwartz equation), younger and middle-age adults [Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation] and older adults [Berlin Initiative Study 1 (BIS1) equation], and these equations lack continuity with ageing. We developed and validated an equation for estimating the glomerular filtration rate that can be used across the full age spectrum (FAS). MethodsThe new FAS equation is based on normalized serum creatinine (SCr/Q), where Q is the median SCr from healthy populations to account for age and sex. Coefficients for the equation are mathematically obtained by requiring continuity during the paediatric-adult and adult-elderly transition. Research studies containing a total of 6870 healthy and kidney-diseased white individuals, including 735 children, <18 years of age, 4371 adults, between 18 and 70 years of age, and 1764 older adults, ≥70 years of age with measured GFR (inulin, iohexol and iothalamate clearance) and isotope dilution mass spectrometry-equivalent SCr, were used for the validation. Bias, precision and accuracy (P30) were evaluated. ResultsThe FAS equation was less biased [-1.7 (95% CI -3.4, -0.2) versus 6.0 (4.5, 7.5)] and more accurate [87.5% (85.1, 89.9) versus 83.8% (81.1, 86.5)] than the Schwartz equation for children and adolescents; less biased [5.0 (4.5, 5.5) versus 6.3 (5.9, 6.8)] and as accurate [81.6% (80.4, 82.7) versus 81.9% (80.7, 83.0)] as the CKD-EPI equation for young and middle-age adults; and less biased [-1.1 (-1.6, -0.6) versus 5.6 (5.1, 6.2)] and more accurate [86.1% (84.4, 87.7) versus 81.8% (79.7, 84.0)] than CKD-EPI for older adults. ConclusionsThe FAS equation has improved validity and continuity across the full age-spectrum and overcomes the problem of implausible eGFR changes in patients which would otherwise occur when switching between more age-specific equations.

Original languageEnglish (US)
Pages (from-to)798-806
Number of pages9
JournalNephrology Dialysis Transplantation
Volume31
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • FAS eGFR equation
  • development and validation
  • healthy and kidney-diseased subjects

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'An estimated glomerular filtration rate equation for the full age spectrum'. Together they form a unique fingerprint.

Cite this