An estimate of the prevalence of reversible left ventricular dysfunction in patients referred for coronary artery bypass surgery

T. F. Christian, T. D. Miller, D. O. Hodge, T. A. Orszulak, Raymond J Gibbons

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background. The prevalence of reversible left ventricular function through revascularization has been difficult to assess because of the referral bias inherent in patients undergoing viability-targeted preoperative testing. Methods and Results. Rest and exercise gated equilibrium radionuclide angiography was performed in 86 patients within 6 months before and any time after coronary artery bypass. Clinical characteristics were recorded for each patient before each of the two radionuclide ventriculograms. Global left ventricular ejection fraction (LVEF) was calculated for each patient at rest. A definite change in LVEF was defined as 0.08 or more points and a probable change as 0.04 or more points. Only patients with a resting LVEF of 0.50 or less were eligible for the study. There was no significant group change in LVEF (0.39 ± 0.08 before surgery vs 0.38 ± 0.11 after surgery; difference not significant). However, a definite improvement in LVEF was seen in 18 patients (21%) and a probable change in an additional 10 (12%). Consequently, one third of the patients had at least a probable improvement in resting left ventricular function. These prevalences were not related to any change in medical therapy. Conclusion. According to a test not specifically designed to evaluate myocardial viability, the prevalence of reversible left ventricular dysfunction is not uncommon, occurring in up to one third of patients referred for coronary revascularization.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalJournal of Nuclear Cardiology
Volume4
Issue number2 I
StatePublished - 1997

Fingerprint

Left Ventricular Dysfunction
Coronary Artery Bypass
Stroke Volume
Gated Blood-Pool Imaging
Left Ventricular Function
Radioisotopes
Referral and Consultation
Exercise

Keywords

  • Coronary revascularization
  • Hibernating myocardium
  • Radionuclide imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

An estimate of the prevalence of reversible left ventricular dysfunction in patients referred for coronary artery bypass surgery. / Christian, T. F.; Miller, T. D.; Hodge, D. O.; Orszulak, T. A.; Gibbons, Raymond J.

In: Journal of Nuclear Cardiology, Vol. 4, No. 2 I, 1997, p. 140-146.

Research output: Contribution to journalArticle

@article{38922c56ac864c1bb13a1d8097cdc60d,
title = "An estimate of the prevalence of reversible left ventricular dysfunction in patients referred for coronary artery bypass surgery",
abstract = "Background. The prevalence of reversible left ventricular function through revascularization has been difficult to assess because of the referral bias inherent in patients undergoing viability-targeted preoperative testing. Methods and Results. Rest and exercise gated equilibrium radionuclide angiography was performed in 86 patients within 6 months before and any time after coronary artery bypass. Clinical characteristics were recorded for each patient before each of the two radionuclide ventriculograms. Global left ventricular ejection fraction (LVEF) was calculated for each patient at rest. A definite change in LVEF was defined as 0.08 or more points and a probable change as 0.04 or more points. Only patients with a resting LVEF of 0.50 or less were eligible for the study. There was no significant group change in LVEF (0.39 ± 0.08 before surgery vs 0.38 ± 0.11 after surgery; difference not significant). However, a definite improvement in LVEF was seen in 18 patients (21{\%}) and a probable change in an additional 10 (12{\%}). Consequently, one third of the patients had at least a probable improvement in resting left ventricular function. These prevalences were not related to any change in medical therapy. Conclusion. According to a test not specifically designed to evaluate myocardial viability, the prevalence of reversible left ventricular dysfunction is not uncommon, occurring in up to one third of patients referred for coronary revascularization.",
keywords = "Coronary revascularization, Hibernating myocardium, Radionuclide imaging",
author = "Christian, {T. F.} and Miller, {T. D.} and Hodge, {D. O.} and Orszulak, {T. A.} and Gibbons, {Raymond J}",
year = "1997",
language = "English (US)",
volume = "4",
pages = "140--146",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "2 I",

}

TY - JOUR

T1 - An estimate of the prevalence of reversible left ventricular dysfunction in patients referred for coronary artery bypass surgery

AU - Christian, T. F.

AU - Miller, T. D.

AU - Hodge, D. O.

AU - Orszulak, T. A.

AU - Gibbons, Raymond J

PY - 1997

Y1 - 1997

N2 - Background. The prevalence of reversible left ventricular function through revascularization has been difficult to assess because of the referral bias inherent in patients undergoing viability-targeted preoperative testing. Methods and Results. Rest and exercise gated equilibrium radionuclide angiography was performed in 86 patients within 6 months before and any time after coronary artery bypass. Clinical characteristics were recorded for each patient before each of the two radionuclide ventriculograms. Global left ventricular ejection fraction (LVEF) was calculated for each patient at rest. A definite change in LVEF was defined as 0.08 or more points and a probable change as 0.04 or more points. Only patients with a resting LVEF of 0.50 or less were eligible for the study. There was no significant group change in LVEF (0.39 ± 0.08 before surgery vs 0.38 ± 0.11 after surgery; difference not significant). However, a definite improvement in LVEF was seen in 18 patients (21%) and a probable change in an additional 10 (12%). Consequently, one third of the patients had at least a probable improvement in resting left ventricular function. These prevalences were not related to any change in medical therapy. Conclusion. According to a test not specifically designed to evaluate myocardial viability, the prevalence of reversible left ventricular dysfunction is not uncommon, occurring in up to one third of patients referred for coronary revascularization.

AB - Background. The prevalence of reversible left ventricular function through revascularization has been difficult to assess because of the referral bias inherent in patients undergoing viability-targeted preoperative testing. Methods and Results. Rest and exercise gated equilibrium radionuclide angiography was performed in 86 patients within 6 months before and any time after coronary artery bypass. Clinical characteristics were recorded for each patient before each of the two radionuclide ventriculograms. Global left ventricular ejection fraction (LVEF) was calculated for each patient at rest. A definite change in LVEF was defined as 0.08 or more points and a probable change as 0.04 or more points. Only patients with a resting LVEF of 0.50 or less were eligible for the study. There was no significant group change in LVEF (0.39 ± 0.08 before surgery vs 0.38 ± 0.11 after surgery; difference not significant). However, a definite improvement in LVEF was seen in 18 patients (21%) and a probable change in an additional 10 (12%). Consequently, one third of the patients had at least a probable improvement in resting left ventricular function. These prevalences were not related to any change in medical therapy. Conclusion. According to a test not specifically designed to evaluate myocardial viability, the prevalence of reversible left ventricular dysfunction is not uncommon, occurring in up to one third of patients referred for coronary revascularization.

KW - Coronary revascularization

KW - Hibernating myocardium

KW - Radionuclide imaging

UR - http://www.scopus.com/inward/record.url?scp=0030890323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030890323&partnerID=8YFLogxK

M3 - Article

C2 - 9115066

AN - SCOPUS:0030890323

VL - 4

SP - 140

EP - 146

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 2 I

ER -