An effective personalized approach to a rare tumor: Prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development

Matthew D. Armstrong, Daniel von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonged survival as a result of personalized treatment designed in part on the basis of molecular and in-vitro data collected on analysis of the tumor and a cell line developed from the liver metastasis. To our knowledge, this represents the first human cell line of ACC. The molecular findings on this case and this patient's cell line may be of use in the management of future cases of this rare tumor and allow the identification of potential novel targets for the effective treatment of this disease.

Original languageEnglish (US)
Pages (from-to)142-152
Number of pages11
JournalJournal of Cancer
Volume2
Issue number1
DOIs
StatePublished - 2011

Keywords

  • Acinar cell pancreatic cancer
  • Cell line
  • Personalized medicine
  • Prolonged survival

ASJC Scopus subject areas

  • Oncology

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