An assessment of the association between childhood asthma and HLA DRB1 03 using extended haplotype analysis

N. A. Hanchard, R. M. Jacobson, G. A. Poland, Y. J. Juhn

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Abstract

Ancestral haplotypes between human leukocyte antigen (HLA) class I and class II alleles are well-recognized in the literature. We previously published a positive association between the class II HLA allele DRB1*03 and the subsequent development of asthma in a retrospective cohort of 383 children. To refine this association, we investigated whether DRB1*03-specific haplotypes extending across the HLA are associated with asthma incidence. We found evidence of strong HLA DRB1*03-dependent linkage disequilibrium across the region, but no association between DRB1*03 ancestral haplotypes and childhood asthma. We did, however, observe a trend toward a positive association between HLA DRB1*03 and asthma by adding non-ancestral DRB1*03 positive haplotypes. Our results suggest that the role of the HLA DRB1*03 in asthma susceptibility is independent of ancestral-haplotype-mediated linkage disequilibrium.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalTissue Antigens
Volume76
Issue number6
DOIs
StatePublished - Dec 1 2010

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Keywords

  • 03
  • Ancestral haplotypes
  • Asthma
  • HLA DRB1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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