An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

Sophia H.L. George; Ayodele Omotoso; Andre Pinto; Aisha Mustapha; Alex P. Sanchez-Covarrubias; Usman Aliyu Umar; Ali Bala Umar; Timothy Abiola Oluwasola; Clement Abu Okolo; Umeh Uchenna Anthony; Francis Ikechukwu Ukekwe; Maisaratu A. Bakari; Aminu M.C. Dahiru; Habiba Ibrahim Abdullahi; Bawa Ahmed Abimiku; Aisha Abdurrahman; Asmau Usman; Saad Aliyu Ahmed; Hadiza Abdullahi Usman; Abba Kabir; George Uchenna Eleje; Michael Emeka Chiemeka; Emily Nzeribe; Ikechukwu Nweke; Saidu Abubakar Kadas; Dauda E. Suleiman; Etim Ekanem; Umemmuo Maureen Uche; Jibrin Paul; Uzoma Maryrose Agwu; Felix O. Edegbe; Rose I. Anorlu; Adekunbiola Banjo; Kayode Olusegun Ajenifuja; Adegboyega Adisa Fawole; Ibrahim O.O. Kazeem; Francis Magaji; Olugbenga Silas; Boma Precious Athanasius; Nyengidiki Kennedy Tamunomie; Emem Bassey; Kunle Abudu; Ibrahim G. Ango; Kabiru Abdullahi; Ishak Lawal; Suleiman Aliyu Kabir; Victor Ekanem; Michael Ezeanochie; Usman Rahman Yahaya; Melissa Nicole Castillo; Vishal Bahall; Vikash Chatrani; Ian Brambury; Saida Bowe; Darron Halliday; George Bruney; Raleigh Butler; Camille Ragin; Folakemi Odedina; Srikar Chamala; Matthew Schlumbrecht; Bala Audu

doi:10.3389/fonc.2021.732443

An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

Sophia H.L. George, Ayodele Omotoso, Andre Pinto, Aisha Mustapha, Alex P. Sanchez-Covarrubias, Usman Aliyu Umar, Ali Bala Umar, Timothy Abiola Oluwasola, Clement Abu Okolo, Umeh Uchenna Anthony, Francis Ikechukwu Ukekwe, Maisaratu A. Bakari, Aminu M.C. Dahiru, Habiba Ibrahim Abdullahi, Bawa Ahmed Abimiku, Aisha Abdurrahman, Asmau Usman, Saad Aliyu Ahmed, Hadiza Abdullahi Usman, Abba KabirGeorge Uchenna Eleje, Michael Emeka Chiemeka, Emily Nzeribe, Ikechukwu Nweke, Saidu Abubakar Kadas, Dauda E. Suleiman, Etim Ekanem, Umemmuo Maureen Uche, Jibrin Paul, Uzoma Maryrose Agwu, Felix O. Edegbe, Rose I. Anorlu, Adekunbiola Banjo, Kayode Olusegun Ajenifuja, Adegboyega Adisa Fawole, Ibrahim O.O. Kazeem, Francis Magaji, Olugbenga Silas, Boma Precious Athanasius, Nyengidiki Kennedy Tamunomie, Emem Bassey, Kunle Abudu, Ibrahim G. Ango, Kabiru Abdullahi, Ishak Lawal, Suleiman Aliyu Kabir, Victor Ekanem, Michael Ezeanochie, Usman Rahman Yahaya, Melissa Nicole Castillo, Vishal Bahall, Vikash Chatrani, Ian Brambury, Saida Bowe, Darron Halliday, George Bruney, Raleigh Butler, Camille Ragin, Folakemi Odedina, Srikar Chamala, Matthew Schlumbrecht, Bala Audu

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.

Original language	English (US)
Article number	732443
Journal	Frontiers in Oncology
Volume	11
DOIs	https://doi.org/10.3389/fonc.2021.732443
State	Published - Nov 26 2021

Keywords

Caribbean
Nigeria
black women
epithelial ovarian cancer (EOC)
germ cell
ovarian cancer
sex cord stromal

ASJC Scopus subject areas

Oncology
Cancer Research

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George, S. H. L., Omotoso, A., Pinto, A., Mustapha, A., Sanchez-Covarrubias, A. P., Umar, U. A., Umar, A. B., Oluwasola, T. A., Okolo, C. A., Anthony, U. U., Ukekwe, F. I., Bakari, M. A., Dahiru, A. M. C., Abdullahi, H. I., Abimiku, B. A., Abdurrahman, A., Usman, A., Ahmed, S. A., Usman, H. A., ... Audu, B. (2021). An Assessment of Ovarian Cancer Histotypes Across the African Diaspora. Frontiers in Oncology, 11, Article 732443. https://doi.org/10.3389/fonc.2021.732443

George, SHL, Omotoso, A, Pinto, A, Mustapha, A, Sanchez-Covarrubias, AP, Umar, UA, Umar, AB, Oluwasola, TA, Okolo, CA, Anthony, UU, Ukekwe, FI, Bakari, MA, Dahiru, AMC, Abdullahi, HI, Abimiku, BA, Abdurrahman, A, Usman, A, Ahmed, SA, Usman, HA, Kabir, A, Eleje, GU, Chiemeka, ME, Nzeribe, E, Nweke, I, Kadas, SA, Suleiman, DE, Ekanem, E, Uche, UM, Paul, J, Agwu, UM, Edegbe, FO, Anorlu, RI, Banjo, A, Ajenifuja, KO, Fawole, AA, Kazeem, IOO, Magaji, F, Silas, O, Athanasius, BP, Tamunomie, NK, Bassey, E, Abudu, K, Ango, IG, Abdullahi, K, Lawal, I, Kabir, SA, Ekanem, V, Ezeanochie, M, Yahaya, UR, Castillo, MN, Bahall, V, Chatrani, V, Brambury, I, Bowe, S, Halliday, D, Bruney, G, Butler, R, Ragin, C, Odedina, F, Chamala, S, Schlumbrecht, M & Audu, B 2021, 'An Assessment of Ovarian Cancer Histotypes Across the African Diaspora', Frontiers in Oncology, vol. 11, 732443. https://doi.org/10.3389/fonc.2021.732443

@article{d263ff41690d4b668320816085878145,

title = "An Assessment of Ovarian Cancer Histotypes Across the African Diaspora",

abstract = "Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student{\textquoteright}s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.",

keywords = "Caribbean, Nigeria, black women, epithelial ovarian cancer (EOC), germ cell, ovarian cancer, sex cord stromal",

author = "George, {Sophia H.L.} and Ayodele Omotoso and Andre Pinto and Aisha Mustapha and Sanchez-Covarrubias, {Alex P.} and Umar, {Usman Aliyu} and Umar, {Ali Bala} and Oluwasola, {Timothy Abiola} and Okolo, {Clement Abu} and Anthony, {Umeh Uchenna} and Ukekwe, {Francis Ikechukwu} and Bakari, {Maisaratu A.} and Dahiru, {Aminu M.C.} and Abdullahi, {Habiba Ibrahim} and Abimiku, {Bawa Ahmed} and Aisha Abdurrahman and Asmau Usman and Ahmed, {Saad Aliyu} and Usman, {Hadiza Abdullahi} and Abba Kabir and Eleje, {George Uchenna} and Chiemeka, {Michael Emeka} and Emily Nzeribe and Ikechukwu Nweke and Kadas, {Saidu Abubakar} and Suleiman, {Dauda E.} and Etim Ekanem and Uche, {Umemmuo Maureen} and Jibrin Paul and Agwu, {Uzoma Maryrose} and Edegbe, {Felix O.} and Anorlu, {Rose I.} and Adekunbiola Banjo and Ajenifuja, {Kayode Olusegun} and Fawole, {Adegboyega Adisa} and Kazeem, {Ibrahim O.O.} and Francis Magaji and Olugbenga Silas and Athanasius, {Boma Precious} and Tamunomie, {Nyengidiki Kennedy} and Emem Bassey and Kunle Abudu and Ango, {Ibrahim G.} and Kabiru Abdullahi and Ishak Lawal and Kabir, {Suleiman Aliyu} and Victor Ekanem and Michael Ezeanochie and Yahaya, {Usman Rahman} and Castillo, {Melissa Nicole} and Vishal Bahall and Vikash Chatrani and Ian Brambury and Saida Bowe and Darron Halliday and George Bruney and Raleigh Butler and Camille Ragin and Folakemi Odedina and Srikar Chamala and Matthew Schlumbrecht and Bala Audu",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 George, Omotoso, Pinto, Mustapha, Sanchez-Covarrubias, Umar, Umar, Oluwasola, Okolo, Anthony, Ukekwe, Bakari, Dahiru, Abdullahi, Abimiku, Abdurrahman, Usman, Ahmed, Usman, Kabir, Eleje, Chiemeka, Nzeribe, Nweke, Kadas, Suleiman, Ekanem, Uche, Paul, Agwu, Edegbe, Anorlu, Banjo, Ajenifuja, Fawole, Kazeem, Magaji, Silas, Athanasius, Tamunomie, Bassey, Abudu, Ango, Abdullahi, Lawal, Kabir, Ekanem, Ezeanochie, Yahaya, Castillo, Bahall, Chatrani, Brambury, Bowe, Halliday, Bruney, Butler, Ragin, Odedina, Chamala, Schlumbrecht and Audu.",

year = "2021",

month = nov,

day = "26",

doi = "10.3389/fonc.2021.732443",

language = "English (US)",

volume = "11",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

AU - George, Sophia H.L.

AU - Omotoso, Ayodele

AU - Pinto, Andre

AU - Mustapha, Aisha

AU - Sanchez-Covarrubias, Alex P.

AU - Umar, Usman Aliyu

AU - Umar, Ali Bala

AU - Oluwasola, Timothy Abiola

AU - Okolo, Clement Abu

AU - Anthony, Umeh Uchenna

AU - Ukekwe, Francis Ikechukwu

AU - Bakari, Maisaratu A.

AU - Dahiru, Aminu M.C.

AU - Abdullahi, Habiba Ibrahim

AU - Abimiku, Bawa Ahmed

AU - Abdurrahman, Aisha

AU - Usman, Asmau

AU - Ahmed, Saad Aliyu

AU - Usman, Hadiza Abdullahi

AU - Kabir, Abba

AU - Eleje, George Uchenna

AU - Chiemeka, Michael Emeka

AU - Nzeribe, Emily

AU - Nweke, Ikechukwu

AU - Kadas, Saidu Abubakar

AU - Suleiman, Dauda E.

AU - Ekanem, Etim

AU - Uche, Umemmuo Maureen

AU - Paul, Jibrin

AU - Agwu, Uzoma Maryrose

AU - Edegbe, Felix O.

AU - Anorlu, Rose I.

AU - Banjo, Adekunbiola

AU - Ajenifuja, Kayode Olusegun

AU - Fawole, Adegboyega Adisa

AU - Kazeem, Ibrahim O.O.

AU - Magaji, Francis

AU - Silas, Olugbenga

AU - Athanasius, Boma Precious

AU - Tamunomie, Nyengidiki Kennedy

AU - Bassey, Emem

AU - Abudu, Kunle

AU - Ango, Ibrahim G.

AU - Abdullahi, Kabiru

AU - Lawal, Ishak

AU - Kabir, Suleiman Aliyu

AU - Ekanem, Victor

AU - Ezeanochie, Michael

AU - Yahaya, Usman Rahman

AU - Castillo, Melissa Nicole

AU - Bahall, Vishal

AU - Chatrani, Vikash

AU - Brambury, Ian

AU - Bowe, Saida

AU - Halliday, Darron

AU - Bruney, George

AU - Butler, Raleigh

AU - Ragin, Camille

AU - Odedina, Folakemi

AU - Chamala, Srikar

AU - Schlumbrecht, Matthew

AU - Audu, Bala

N1 - Publisher Copyright: Copyright © 2021 George, Omotoso, Pinto, Mustapha, Sanchez-Covarrubias, Umar, Umar, Oluwasola, Okolo, Anthony, Ukekwe, Bakari, Dahiru, Abdullahi, Abimiku, Abdurrahman, Usman, Ahmed, Usman, Kabir, Eleje, Chiemeka, Nzeribe, Nweke, Kadas, Suleiman, Ekanem, Uche, Paul, Agwu, Edegbe, Anorlu, Banjo, Ajenifuja, Fawole, Kazeem, Magaji, Silas, Athanasius, Tamunomie, Bassey, Abudu, Ango, Abdullahi, Lawal, Kabir, Ekanem, Ezeanochie, Yahaya, Castillo, Bahall, Chatrani, Brambury, Bowe, Halliday, Bruney, Butler, Ragin, Odedina, Chamala, Schlumbrecht and Audu.

PY - 2021/11/26

Y1 - 2021/11/26

N2 - Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.

AB - Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.

KW - Caribbean

KW - Nigeria

KW - black women

KW - epithelial ovarian cancer (EOC)

KW - germ cell

KW - ovarian cancer

KW - sex cord stromal

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U2 - 10.3389/fonc.2021.732443

DO - 10.3389/fonc.2021.732443

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AN - SCOPUS:85120938070

SN - 2234-943X

VL - 11

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 732443

ER -

An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

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Keywords

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