An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition

Gary S. Stein, Andre J van Wijnen, Janet L. Stein, Jane B. Lian, Martin Montecino, Sayyed K. Zaidi, Corey Braastad

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A prominent role for the execution of cell cycle and growth regulatory mechanisms within the three-dimensional context of nuclear architecture is becoming increasingly evident. Signaling pathways and regulatory networks that govern activation and suppression of genes controlling proliferation are functionally integrated for the organization and assembly of transcriptional machinery in nuclear microenvironments. The transcriptional activation of histone genes at the G1/S phase transition (S-point) is temporarily, functionally, and spatially distinct from transcriptional mechanisms at the restriction point (R-point). The spatial distinction in R-point versus S-point control is the localization of clustered histone gene loci at cajal bodies, which is modulated during the cell cycle. Histone nuclear factor P (HiNF-P), the principal factor mediating H4 histone gene transcription, is the final link in the signaling cascade that is initiated with growth factor dependent induction of cyclin E/CDK2 kinase activity at the R-point and culminates in the NPAT-mediated activation of histone H4 genes through HiNF-P at the G1/S phase cell-cycle transition.

Original languageEnglish (US)
Pages (from-to)706-710
Number of pages5
JournalJournal of Cellular Physiology
Volume209
Issue number3
DOIs
StatePublished - Dec 2006
Externally publishedYes

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G1 Phase
Cell Cycle Checkpoints
S Phase
Histones
Cell Cycle
Cells
Genes
Chemical activation
Transcriptional Activation
Cyclin E
Phase Transition
Transcription
Machinery
Intercellular Signaling Peptides and Proteins
Phosphotransferases
Phase transitions
Growth

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Montecino, M., Zaidi, S. K., & Braastad, C. (2006). An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. Journal of Cellular Physiology, 209(3), 706-710. https://doi.org/10.1002/jcp.20843

An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. / Stein, Gary S.; van Wijnen, Andre J; Stein, Janet L.; Lian, Jane B.; Montecino, Martin; Zaidi, Sayyed K.; Braastad, Corey.

In: Journal of Cellular Physiology, Vol. 209, No. 3, 12.2006, p. 706-710.

Research output: Contribution to journalArticle

Stein, GS, van Wijnen, AJ, Stein, JL, Lian, JB, Montecino, M, Zaidi, SK & Braastad, C 2006, 'An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition', Journal of Cellular Physiology, vol. 209, no. 3, pp. 706-710. https://doi.org/10.1002/jcp.20843
Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino M, Zaidi SK et al. An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. Journal of Cellular Physiology. 2006 Dec;209(3):706-710. https://doi.org/10.1002/jcp.20843
Stein, Gary S. ; van Wijnen, Andre J ; Stein, Janet L. ; Lian, Jane B. ; Montecino, Martin ; Zaidi, Sayyed K. ; Braastad, Corey. / An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition. In: Journal of Cellular Physiology. 2006 ; Vol. 209, No. 3. pp. 706-710.
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