An architectural genetic and epigenetic perspective

Gary S. Stein, Janet L. Stein, Andre J van Wijnen, Jane B. Lian, Sayyed K. Zaidi, Jeffrey A. Nickerson, Martin A. Montecino, Daniel W. Young

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The organization and intranuclear localization of nucleic acids and regulatory proteins contribute to both genetic and epigenetic parameters of biological control. Regulatory machinery in the cell nucleus is functionally compartmentalized in microenvironments (focally organized sites where regulatory factors reside) that provide threshold levels of factors required for transcription, replication, repair and cell survival. The common denominator for nuclear organization of regulatory machinery is that each component of control is architecturally configured and every component of control is embedded in architecturally organized networks that provide an infrastructure for integration and transduction of regulatory signals. It is realistic to anticipate emerging mechanisms that account for the organization and assembly of regulatory complexes within the cell nucleus can provide novel options for cancer diagnosis and therapy with maximal specificity, reduced toxicity and minimal off-target complications.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalIntegrative Biology
Volume3
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Cell Nucleus
Epigenomics
Cells
Machinery
Nucleic Acids
Signal Transduction
Cell Survival
Transcription Factors
Transcription
Toxicity
Repair
Neoplasms
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Cite this

Stein, G. S., Stein, J. L., van Wijnen, A. J., Lian, J. B., Zaidi, S. K., Nickerson, J. A., ... Young, D. W. (2011). An architectural genetic and epigenetic perspective. Integrative Biology, 3(4), 297-303. https://doi.org/10.1039/c0ib00103a

An architectural genetic and epigenetic perspective. / Stein, Gary S.; Stein, Janet L.; van Wijnen, Andre J; Lian, Jane B.; Zaidi, Sayyed K.; Nickerson, Jeffrey A.; Montecino, Martin A.; Young, Daniel W.

In: Integrative Biology, Vol. 3, No. 4, 04.2011, p. 297-303.

Research output: Contribution to journalArticle

Stein, GS, Stein, JL, van Wijnen, AJ, Lian, JB, Zaidi, SK, Nickerson, JA, Montecino, MA & Young, DW 2011, 'An architectural genetic and epigenetic perspective', Integrative Biology, vol. 3, no. 4, pp. 297-303. https://doi.org/10.1039/c0ib00103a
Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA et al. An architectural genetic and epigenetic perspective. Integrative Biology. 2011 Apr;3(4):297-303. https://doi.org/10.1039/c0ib00103a
Stein, Gary S. ; Stein, Janet L. ; van Wijnen, Andre J ; Lian, Jane B. ; Zaidi, Sayyed K. ; Nickerson, Jeffrey A. ; Montecino, Martin A. ; Young, Daniel W. / An architectural genetic and epigenetic perspective. In: Integrative Biology. 2011 ; Vol. 3, No. 4. pp. 297-303.
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